Cellular and Biomolecular Mechanics and Mechanobiology

1. Front Matter

   Pages i-ix

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2. Cytoskeletal Mechanics and Cellular Mechanotransduction: A Molecular Perspective

   • Hamed Hatami-Marbini, Mohammad R. K. Mofrad

   Pages 3-27

3. Forces During Cell Adhesion and Spreading: Implications for Cellular Homeostasis

   • Shawn P. Carey, Jonathan M. Charest, Cynthia A. Reinhart-King

   Pages 29-69

4. The Physical Mechanical Processes that Shape Tissues in the Early Embryo

   • Lance A. Davidson

   Pages 71-97

5. Mechanobiology of Primary Cilia

   • Ronald Y. Kwon, David A. Hoey, Christopher R. Jacobs

   Pages 99-124

6. Mechanical Response of Living Cells to Contacting Shear Forces

   • Alison C. Dunn, W. Gregory Sawyer, Malisa Sarntinoranont, Roger Tran-Son-Tay

   Pages 125-141

7. Microfabricated Devices for Studying Cellular Biomechanics and Mechanobiology

   • Christopher Moraes, Yu Sun, Craig A. Simmons

   Pages 145-175

8. Nanotechnology Usages for Cellular Adhesion and Traction Forces

   • Sangyoon J. Han, Nathan J. Sniadecki

   Pages 177-200

9. The Mechanical Environment of Cells in Collagen Gel Models

   • Kristen L. Billiar

   Pages 201-245

10. Biomechanical Characterization of Single Chondrocytes

    • Johannah Sanchez-Adams, Kyriacos A. Athanasiou

    Pages 247-266

11. Mechanics of Airway Smooth Muscle Cells and the Response to Stretch

    • Geoffrey N. Maksym

    Pages 261-293

12. Biomechanical Modelling of Cells in Mechanoregulation

    • Alexander B. Lennon, Hanifeh Khayyeri, Feng Xue, Patrick J. Prendergast

    Pages 297-329

13. Finite Element Modeling of Cellular Mechanics Experiments

    • Noa Slomka, Amit Gefen

    Pages 331-344

14. Multiscale Computation of Cytoskeletal Mechanics During Blebbing

    • Sorin Mitran, Jennifer Young

    Pages 345-371

15. Mechanobiology and Finite Element Analysis of Cellular Injury During Microbubble Flows

    • Samir N. Ghadiali, Hannah L. Dailey

    Pages 373-429

16. Mathematical Modelling of Cell Adhesion in Tissue Engineering using Continuum Models

    • Liesbet Geris, Alf Gerisch

    Pages 431-450

17. Cell–Material Communication: Mechanosensing Modelling for Design in Tissue Engineering

    • J. M. García-Aznar, J. A. Sanz-Herrera, P. Moreo

    Pages 451-462

18. Structure–Mechanical Property Changes in Nucleus arising from Breast Cancer

    • Qingsen Li, Chwee Teck Lim

    Pages 465-475

19. Adhesion and Signaling of Tumor Cells to Leukocytes and Endothelium in Cancer Metastasis

    • Cheng Dong

    Pages 477-521

20. Cellular Mechanics of Acute Leukemia and Chemotherapy

    • Wilbur A. Lam, Daniel A. Fletcher

    Pages 523-558

This book describes these exciting new developments, and presents experimental and computational findings that altogether describe the frontier of knowledge in cellular and biomolecular mechanics, and the biological implications, in health and disease. The book is written for bioengineers with interest in cellular mechanics, for biophysicists, biochemists, medical researchers and all other professionals with interest in how cells produce and respond to mechanical loads.

• Biorheology
• Cell deformation and damage
• Cell-matrix mechanical interactions
• Cytoskeleton
• Mechanotransduction

From the reviews:

“The book comprises a number of articles by experts in the field of cellular and biomolecular mechanics. … In my opinion this book is an excellent start for any scientist who wants to enter this very challenging, intriguing and rapidly developing field of research. For the researcher, already active in this field, the book provides an outstanding overview of the state of the art of research in this area containing both extensive references and contributions from world leading experts within this field.” (Cees Oomens, Computer Methods in Biomechanics and Biomedical Engineering, July, 2012)

• Fac. Engineering, Dept. Biomedical Engineering, Tel Aviv University, Ramat Aviv, Israel

  Amit Gefen

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