Molecular Basis of Multiple Sclerosis

1. Front Matter

   Pages i-viii

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2. The Genetics of Multiple Sclerosis

   • Jan Hillert

   Pages 1-19

3. Potential Triggers of MS

   • Jane E. Libbey, Robert S. Fujinami

   Pages 21-42

4. Immunological Basis for the Development of Tissue Inflammation and Organ-Specific Autoimmunity in Animal Models of Multiple Sclerosis

   • Thomas Korn, Meike Mitsdoerffer, Vijay K. Kuchroo

   Pages 43-74

5. T-Cells in Multiple Sclerosis

   • Christopher Severson, David A. Hafler

   Pages 75-98

6. B Cells and Antibodies in MS

   • Markus Reindl, Bettina Kuenz, Thomas Berger

   Pages 99-113

7. Cooperation of B Cells and T Cells in the Pathogenesis of Multiple Sclerosis

   • Martin S. Weber, Bernhard Hemmer

   Pages 115-126

8. Role of NK Cells and Invariant NKT Cells in Multiple Sclerosis

   • Kaori Sakuishi, Sachiko Miyake, Takashi Yamamura

   Pages 127-147

9. Antigen Processing and Presentation in Multiple Sclerosis

   • Christina Stoeckle, Eva Tolosa

   Pages 149-172

10. Immune-Mediated CNS Damage

    • Katrin Kierdorf, Yiner Wang, Harald Neumann

    Pages 173-196

11. Neuro-Immune Crosstalk in CNS Diseases

    • Martin Kerschensteiner, Edgar Meinl, Reinhard Hohlfeld

    Pages 197-216

12. Prospects for Antigen-Specific Tolerance Based Therapies for the Treatment of Multiple Sclerosis

    • Danielle M. Turley, Stephen D. Miller

    Pages 217-235

13. Immuno-Therapeutic Potential of Haematopoietic and Mesenchymal Stem Cell Transplantation in MS

    • Paolo A. Muraro, Antonio Uccelli

    Pages 237-257

14. Multiple Sclerosis Therapies: Molecular Mechanisms and Future

    • Paulo Fontoura, Hideki Garren

    Pages 259-285

15. Examination of the Role of MRI in Multiple Sclerosis: A Problem Orientated Approach

    • Henry F. McFarland

    Pages 287-301

16. Back Matter

    Pages 303-307

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Despite major efforts by the scientific community over the years, our understanding of the pathogenesis or the mechanisms of injury of multiple sclerosis is still limited. Consequently, the current strategies for treatment and management of patients are limited in their efficacy. The mechanisms of tissue protection and repair are probably even less understood. One reason for these limitations is the enormous complexity of the disease and every facet of its pathogenesis, the mechanisms of tissue injury, the diagnostic procedures and finally the efficacy of treatments and their side effects. The aim of this book is to review the most recent advances made in this highly complex field.

• Antigen
• Immune System
• Immunity
• Transplantation
• cells
• genetics
• molecular mechanisms
• tissue

• Institut für Neuroimmunologie und, Klinische Multiple-Sklerose-Forschung, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany

  Roland Martin

• , Clinical Department of Neurology, Innsbruck Medical University, Innsbruck, Austria

  Andreas Lutterotti

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