Editors:
Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 286)
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Table of contents (6 chapters)
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Front Matter
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Back Matter
About this book
This book reviews knowledge on the interconnection of signal transduction and endocytosis/intracellular trafficking. The chapters cover knowledge obtained by using different model systems. The first chapter deals with Receptor Tyrosin Kinases (RTKs) with emphasis on the Epidermal Growth Factor Receptor (EGF receptor) and the Platelet Derived Growth Factor Receptor (PDGF receptor). The second chapter deals with the RTK c-Met and with how this RTK becomes carcinogenic. The third chapter reviews recent understanding on the mechanisms of action of the numerous fibroblast growth factors and their receptors. In the fourth chapter we learn about the trafficking of and signalling from the Growth Hormone Receptor and how this receptor is controlled by ubiquitination. The fifth chapter is devoted to the Interleukin II receptor, essential for activation of T cells. Links between ubiquitination, signalling, endocytosis, and sorting are reviewed. The last chapter discusses current views on how monoubiquitination controls both signalling and trafficking and thereby the final outcome of receptor activation.
Editors and Affiliations
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Institute of Pathology, Rikshospitalet University Hospital, Oslo, Norway
Inger Helene Madshus
Bibliographic Information
Book Title: Signalling from Internalised Growth Factor Receptors
Editors: Inger Helene Madshus
Series Title: Current Topics in Microbiology and Immunology
DOI: https://doi.org/10.1007/978-3-540-69494-6
Publisher: Springer Berlin, Heidelberg
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eBook Packages: Springer Book Archive
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 2004
Hardcover ISBN: 978-3-540-21038-2Published: 09 July 2004
Softcover ISBN: 978-3-642-05912-4Published: 03 March 2011
eBook ISBN: 978-3-540-69494-6Published: 05 June 2013
Series ISSN: 0070-217X
Series E-ISSN: 2196-9965
Edition Number: 1
Number of Pages: IX, 190
Number of Illustrations: 27 b/w illustrations, 4 illustrations in colour
Topics: Medical Microbiology