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Disposable Bioreactors

  • Book
  • © 2010

Overview

Editors:
  1. Regine Eibl

    1. Hochschule Wädenswil, Wädenswil, Switzerland

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    You can also search for this editor in PubMed   Google Scholar

  2. Dieter Eibl

    1. Hochschule Wädenswil, Wädenswil, Switzerland

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Covers trends in modern biotechnology
  • All aspects of this interdisciplinary technology, where knowledge, methods and expertise are required from chemistry, biochemistry, microbiology, genetics, chemical engineering and computer science, are treated
  • More information as well as the electronic version available at springer.com

Part of the book series: Advances in Biochemical Engineering/Biotechnology (ABE, volume 115)

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Table of contents (8 chapters)

  1. Front Matter

    Pages i-xiii
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  2. Disposable Bioreactors: Maturation into Pharmaceutical Glycoprotein Manufacturing

    • René Brecht
    Pages 1-31

  3. Use of Orbital Shaken Disposable Bioreactors for Mammalian Cell Cultures from the Milliliter-Scale to the 1,000-Liter Scale

    • Xiaowei Zhang, Matthieu Stettler, Dario De Sanctis, Marco Perrone, Nicola Parolini, Marco Discacciati et al.
    Pages 33-53

  4. Bag Bioreactor Based on Wave-Induced Motion: Characteristics and Applications

    • Regine Eibl, Sören Werner, Dieter Eibl
    Pages 55-87

  5. Disposable Bioreactors for Plant Micropropagation and Mass Plant Cell Culture

    • Jean-Paul Ducos, Bénédicte Terrier, Didier Courtois
    Pages 89-115

  6. Transport Advances in Disposable Bioreactors for Liver Tissue Engineering

    • Gerardo Catapano, John F. Patzer II, Jörg Christian Gerlach
    Pages 117-143

  7. Sensors in Disposable Bioreactors Status and Trends

    • Anne Glindkamp, Daniel Riechers, Christoph Rehbock, Bernd Hitzmann, Thomas Scheper, Kenneth F. Reardon
    Pages 145-169

  8. Disposables in Downstream Processing

    • Uwe Gottschalk
    Pages 171-183

  9. Hybrid and Disposable Facilities for Manufacturing of Biopharmaceuticals: Pros and Cons

    • Aline Ravisé, Emmanuelle Cameau, Georges De Abreu, Alain Pralong
    Pages 185-219

  10. Back Matter

    Pages 221-223
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Keywords

About this book

Over the past five years, the immense financial pressure on the development and manufacturing of biopharmaceuticals has resulted in the increasing use and acce- ance of disposables, which are discarded after harvest and therefore intended only for single use. In fact, such disposables are implemented in all the main bioprocess production stages today and an even higher growth than those in the biopharmac- tical market is predicted (reaching double figures). Alongside disposable filter capsules, membrane chromatography units, tubing, connectors, flexible containers processing or containing fluids, freezer systems, mixers and pumps, and fully c- trolled disposable bioreactors of up to 2,000 L culture volume are already available on the market. Numerous studies highlight the advantages of disposable bioreactors and reveal their potential for simple, safe and fast seed inoculum production, process devel- ment and small as well as middle volume production (e.g. bioactive substances, viruses for vaccines and gene therapies etc.). They suggest that such disposable bioreactors (typically characterized by the cultivation chamber or bag from plastic materials) may be advantageous for plant, animal and microbial cells. Running industrial activities such as CFD-modelling, development of single-use process monitoring and control technology, and standardized film formulations are attempting to resolve the limitations of the current disposable bioreactors. These achievements, along with substantial improvements in product yield, will reduce the use of stainless steel in the biomanufacturing facilities of the future.

Editors and Affiliations

  • Hochschule Wädenswil, Wädenswil, Switzerland

    Regine Eibl, Dieter Eibl

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