Vaccines for Pandemic Influenza

1. Front Matter

   Pages i-xviii

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2. Pandemic Influenza Overview

   1. Front Matter

      Pages 1-1

      PDF

   2. Pandemic Influenza as a Current Threat

      • Hui-Ling Yen, Robert G. Webster

      Pages 3-24

   3. Antigenic Cross-Reactivity Among H5N1 Viruses

      • Adrianus C. M. Boon, Richard J. Webby

      Pages 25-40

3. Current Approaches for Human and Avian Vaccine Production

   1. Front Matter

      Pages 42-42

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   2. Seasonal Influenza Vaccines

      • Anthony E. Fiore, Carolyn B. Bridges, Nancy J. Cox

      Pages 43-82

   3. Generation and Characterization of Candidate Vaccine Viruses for Prepandemic Influenza Vaccines

      • Eduardo O’Neill, Ruben O. Donis

      Pages 83-108

   4. Live Attenuated Vaccines for Pandemic Influenza

      • Grace L. Chen, Kanta Subbarao

      Pages 109-132

   5. Influenza Vaccines for Avian Species

      • Darrell R. Kapczynski, David E. Swayne

      Pages 133-152

   6. Development and Application of Avian Influenza Vaccines in China

      • Hualan Chen, Zhigao Bu

      Pages 153-162

4. Novel Vaccine Approaches

   1. Front Matter

      Pages 164-164

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   2. Designing Vaccines for Pandemic Influenza

      • Taisuke Horimoto, Yoshihiro Kawaoka

      Pages 165-176

   3. Attenuated Influenza Virus Vaccines with Modified NS1 Proteins

      • Jüergen A. Richt, Adolfo García-Sastre

      Pages 177-195

   4. DNA Vaccines Against Influenza Viruses

      • Jin Hyang Kim, Joshy Jacob

      Pages 197-210

   5. Recombinant Proteins Produced in Insect Cells

      • John Treanor

      Pages 211-225

   6. Influenza Neuraminidase as a Vaccine Antigen

      • Matthew J. Sylte, David L. Suarez

      Pages 227-241

   7. Recombinant Vectors as Influenza Vaccines

      • Sarah A. Kopecky-Bromberg, Peter Palese

      Pages 243-267

   8. Influenza Virus-Like Particles as Pandemic Vaccines

      • S. M. Kang, P. Pushko, R. A. Bright, G. Smith, R. W. Compans

      Pages 269-289

   9. Pandemic Influenza Vaccines

      • Lauren J. DiMenna, Hildegund C. J. Ertl

      Pages 291-321

   10. Adjuvants for Pandemic Influenza Vaccines

       • Robert L. Atmar, Wendy A. Keitel

       Pages 323-344

Recent years have seen unprecedented outbreaks of avian influenza A viruses. In particular, highly pathogenic H5N1 viruses have not only resulted in widespread outbreaks in domestic poultry, but have been transmitted to humans, resulting in numerous fatalities. The rapid expansion in their geographic distribution and the possibility that these viruses could acquire the ability to spread from person to person raises the risk that such a virus could cause a global pandemic with high morbidity and mortality. An effective influenza vaccine represents the best approach to prevent and control such an emerging pandemic. However, current influenza vaccines are directed at existing seasonal influenza viruses, which have little or no antigenic relationship to the highly pathogenic H5N1 strains. Concerns about pandemic preparedness have greatly stimulated research activities to develop eff- tive vaccines for pandemic influenza viruses, and to overcome the limitations inh- ent in current approaches to vaccine production and distribution. These limitations include the use of embryonated chicken eggs as the substrate for vaccine prod- tion, which is time-consuming and could involve potential biohazards in growth of new virus strains. Other limitations include the requirement that the current inac- vated influenza vaccines be administered using needles and syringes, requiring trained personnel, which could be a bottleneck when attempting to vaccinate large populations in mass campaigns. In addition, the current inactivated vaccines that are delivered by injection elicit limited protective immunity in the upper respiratory tract where the infection process is initiated.

• Antigen
• DNA vaccines
• H5N1 viruses
• NS1 proteins
• Radiologieinformationssystem
• attenuated vaccines
• avian influenza
• influenza virus-like particles
• microneedle patches
• pandemic influenza
• protein
• seasonal influenza
• transcutaneous immunization
• vacci

• School of Medicine, Emory University, Atlanta, U.S.A.

  Richard W. Compans, Walter A. Orenstein

Policies and ethics