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Pharmacology and Therapeutics of Cough

  • Book
  • © 2009

Overview

Editors:
  1. Kian Fan Chung

    1. National Heart & Lung Institute, Imperial College, London, UK

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    You can also search for this editor in PubMed   Google Scholar

  2. John Widdicombe

    1. University of London, London, UK

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 187)

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Table of contents (18 chapters)

  1. Front Matter

    Pages i-xii
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  2. Cough: Setting the Scene

    • K. F. Chung, J. G. Widdicombe
    Pages 1-21

  3. Cough Sensors. I. Physiological and Pharmacological Properties of the Afferent Nerves Regulating Cough

    • B. J. Canning, Y. -L. Chou
    Pages 23-47

  4. Cough Sensors. II. Transient Receptor Potential Membrane Receptors on Cough Sensors

    • S. Materazzi, R. Nassini, R. Gatti, M. Trevisani, P. Geppetti
    Pages 49-61

  5. Cough Sensors. III. Opioid and Cannabinoid Receptors on Vagal Sensory Nerves

    • M. G. Belvisi, D. J. Hele
    Pages 63-76

  6. Cough Sensors. IV. Nicotinic Membrane Receptors on Cough Sensors

    • L. -Y. Lee, Q. Gu
    Pages 77-98

  7. Cough Sensors. V. Pharmacological Modulation of Cough Sensors

    • S. B. Mazzone, B. J. Undem
    Pages 99-127

  8. Peripheral Mechanisms I: Plasticity of Peripheral Pathways

    • M. A. McAlexander, M. J. Carr
    Pages 129-154

  9. Peripheral Mechanisms II: The Pharmacology of Peripherally Active Antitussive Drugs

    • D. Spina, I. McFadzean, F.K.R. Bertram, C. P. Page
    Pages 155-186

  10. Central Mechanisms I: Plasticity of Central Pathways

    • C. -Y. Chen, J. P. Joad, J. Bric, A. C. Bonham
    Pages 187-201

  11. Central Mechanisms II: Pharmacology of Brainstem Pathways

    • D. C. Bolser
    Pages 203-217

  12. Central Mechanisms III: Neuronal Mechanisms of Action of Centrally Acting Antitussives Using Electrophysiological and Neurochemical Study Approaches

    • K. Takahama, T. Shirasaki, F. Soeda
    Pages 219-240

  13. Central Mechanisms IV: Conscious Control of Cough and the Placebo Effect

    • R. Eccles
    Pages 241-262

  14. Clinical Cough I: The Urge-To-Cough: A Respiratory Sensation

    • P. W. Davenport
    Pages 263-276

  15. Clinical Cough II: Therapeutic Treatments and Management of Chronic Cough

    • A. H. Morice, L. McGarvey
    Pages 277-295

  16. Clinical Cough III: Measuring the Cough Response in the Laboratory

    • P. V. Dicpinigaitis
    Pages 297-310

  17. Clinical Cough IV:What is the Minimal Important Difference for the Leicester Cough Questionnaire?

    • A. A. Raj, D. I. Pavord, S. S. Birring
    Pages 311-320

  18. Clinical Cough V: Complementary and Alternative Medicine: Therapy of Cough

    • J. G. Widdicombe, E. Ernst
    Pages 321-342

  19. Clinical Cough VI: The Need for New Therapies for Cough: Disease-Specific and Symptom-Related Antitussives

    • K. F. Chung
    Pages 343-368

  20. Back Matter

    Pages 369-375
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Keywords

About this book

The last decade or so has seen remarkable advances in our knowledge of cough. This applies especially to its basic mechanisms: the types of airway sensors, the phar- cological receptors on their membranes, the brainstem organization of the ‘cough centre’, and the involvement of the cerebral cortex in the sensations and the vol- tary control of cough. With the exception of the last of these, nearly all the studies have been on experimental animals rather than humans, for obvious reasons. One group of experimental studies has particular relevance to human patients, and that is the demonstration of the sensitization of cough pathways both in the periphery and in the brainstem. Similar sensitizations have been shown for patients with chronic cough or who have been exposed to pollutants, and it is reasonable to suppose that this is the basis of their cough and that the underlying mechanisms are generally similar in humans and other species. Important advances are also being made in clinical cough research. For the three main causes of clinical cough, asthma, post-nasal drip syndrome, and gast- oesophageal re?ux disease, we are beginning to understand the pathological processes involved. There remains a diagnostically obdurate group of idiopathic chronic coughers, but even for them approaches are being devised to clarify und- lying mechanisms and to establish diagnoses. Perhaps surprisingly, the ?eld in which there has been the least spectacular - vance is the therapy of cough.

Editors and Affiliations

  • National Heart & Lung Institute, Imperial College, London, UK

    Kian Fan Chung

  • University of London, London, UK

    John Widdicombe

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