The Impact of Tumor Biology on Cancer Treatment and Multidisciplinary Strategies

1. Front Matter

   Pages I-X

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2. Tumorigenesis

   • Michael J. Atkinson, Soile Tapio

   Pages 1-17

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3. Tumor Growth and Cell Proliferation

   • Marek Los, Iran Rashedi, Soumya Panigrahi, Thomas Klonisch, Klaus Schulze-Osthoff

   Pages 19-37

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4. Tumor Angiogenesis

   • Vesile Schneider, Hans Christian Rischke, Joachim Drevs

   Pages 39-50

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5. Pathophysiology of Solid Tumors

   • Peter Vaupel

   Pages 51-92

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6. Adhesion, Invasion, Integrins, and Beyond

   • Nils Cordes, Stephanie Hehlgans, Iris Eke

   Pages 93-115

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7. The Biology of Cancer Metastasis

   • Miodrag Gužvić, Christoph A. Klein

   Pages 117-128

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8. Role of the Immune System in Cancer Development and Therapeutic Implications

   • Gabriele Multhoff, Sabrina T. Astner

   Pages 129-145

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9. Tumor Detection by Biological Markers

   • Carsten Nieder, Adam Pawinski

   Pages 147-151

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10. Tumor Imaging with Special Emphasis on the Role of Positron Emission Tomography in Radiation Treatment Planning

    • Anca-Ligia Grosu, Wolfgang A. Weber, Ursula Nestle

    Pages 153-167

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11. Quantitative Cell Kill of Radio- and Chemotherapy

    • Michael Molls, Carsten Nieder, Claus Belka, Jan Norum

    Pages 169-190

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12. The Impact of Molecularly Targeted Therapy in Multi-Modality Therapy

    • Shiyu Song, Paul Dent, Steven Grant

    Pages 191-219

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13. Target-Based Interventions to Treat Radiation-Induced Lung Injury

    • Isabel L. Jackson, Mitchell S. Anscher, Zeljko Vujaskovic

    Pages 221-241

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14. Mechanisms of Treatment Resistance: Molecular and Clinical Examples for Radio- and Chemotherapy

    • Carsten Nieder

    Pages 243-250

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15. DNA Repair and Cell Cycle Regulation After Ionizing Irradiation

    • George Iliakis, Jochen Dahm-Daphi, Ekkehard Dikomey

    Pages 251-271

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16. Physiological Mechanisms of Treatment Resistance

    • Peter Vaupel

    Pages 273-290

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17. Influence of Time Factor and Repopulation on Treatment Resistance

    • Daniel Zips

    Pages 291-298

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18. Molecular Tools, Expression Profiling

    • Angela M. Kaindl, Konrad Oexle

    Pages 299-311

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19. Strategies of Gene Transfer and Silencing, and Technical Considerations

    • Kristoffer Valerie, Paul R. Graves

    Pages 313-321

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20. Tumor Biology’s Impact on Clinical Cure Rates

    • Michael Baumann, Mechthild Krause

    Pages 323-334

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Te rapidly changing concepts in radiation oncology with the development of more precise - strumentation for delivery of radiation therapy and a greater emphasis on hypofractionation technologies require a very intimate knowledge of tumor biology and the infuence of various biologic factors on dose distribution within the tumor in terms of homogeneity as well as prev- tion of any late efects on normal tissue surrounding the tumor itself. Not only are these major factors in clinical practice but also the known factors of inhomogeneity of cancer cells, the impact of microenvironment in terms of radiation efect, and host factors make it mandatory to design therapeutic strategies to improve the outcome and to diminish any potential short-term or lo- term risks from the radiation therapy. Te authors have developed an outstanding text that deals with these strategies and how they would impact on established and emerging new technologies and treatment. Te context of the presentations within a multidisciplinary combined modality therapy program is incredibly - portant. In this volume, various topics are reviewed including tumor genesis, cell proliferation, - giogenesis, the physiologic characteristics of malignant tissues, invasion and adhesion, the route and role pursued in the development of metastasis, and the role of the human immune system in cancer prevention and development.

• Cancer
• Cancer Biology
• Cancer Treatment
• Chemotherapy
• Radiotherapy
• Tumor
• angiogenesis
• imaging
• positron emission tomography
• tumor growth
• tumorigenesis
• Radiaton Oncology
• surgical oncology

From the reviews: “The stated aim of the editors of this book is ‘to provide the practising radiation oncologist with a concise overview of the most important and up-to-date information pertaining to tumour biology as it impacts on cancer treatment’ … useful guide to the molecular era of cancer biology and personalised cancer therapy, particularly in relation to radiation oncology. … The book would be of interest to any oncologist and would serve as a useful revision tool for the FRCR part 1 examination.” (Joe O’Sullivan, RAD Magazine, December, 2009) Aus den Rezensionen: “Dieses umfassende Lehrbuch erläutert alle wesentlichen Gesichtspunkte der Tumorbiologie ... Die Literaturhinweise sind umfangreich, vollständig und aktuell, sofern dies in einem Lehrbuch überhaupt möglich ist. Die Autoren sind international ausgewiesene Grundlagenwissenschaftler und klinische Krebsforscher. Die Kapitel weisen ein qualitativ hochwertiges Layout mit zahlreichen, durchgehend farbigen Bildern auf und sind gut lesbar. Das Buch stellt eine wesentliche Bereicherung der tumorbiologischen Literatur dar. Wir empfehlen es als aktuelles radiobiologisches Standardwerk.“ (Stephan Roth, in: Strahlentherapie und Onkologie, 1/December/2009, S. 844)

• Klinik und Poliklinik für Strahlentherapie und Radiologische Onkologie, Klinikum Rechts der Isar der Technischen Universität München, München, Germany

  Michael Molls

• Institute of Physiology and Pathophysiology, University Medical Center, Mainz, Germany

  Peter Vaupel

• Department of Internal Medicine – Oncology, Nordlandssykehuset HF Hospital, Bodø, Norway

  Carsten Nieder

• Department of Radiation Oncology, Virginia Commonwealth University School of Medicine, Richmond, USA

  Mitchell S. Anscher

M. Molls, Professor, Chairman of the Department of Radiation Oncology, Klinikum rechts der Isar der TU Muenchen, Germany

C. Nieder, Professor at the University of Tromsø, Norway, Oncologist

M Anscher, Professor and Chairman, Department of Radiation Oncology, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA

Policies and ethics