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Specialization and Complementation of Humoral Immune Responses to Infection

  • Book
  • © 2008

Overview

Editors:
  1. Tim Manser

    1. Department of Microbiology and Immunology, Jefferson Medical College, Philadelphia, USA

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Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 319)

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Table of contents (6 chapters)

  1. Front Matter

    Pages i-xii
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  2. Pattern Recognition by B Cells: The Role of Antigen Repetitiveness Versus Toll-Like Receptors

    • H. J. Hinton, A. Jegerlehner, M. F. Bachmann
    Pages 1-15

  3. The Multifunctional Role of Antibodies in the Protective Response to Bacterial T Cell-Independent Antigens

    • J. J. Mond, J. F. Kokai-Kun
    Pages 17-40

  4. B Cell Lineage Contributions to Antiviral Host Responses

    • N. Baumgarth, Y. S. Choi, K. Rothaeusler, Y. Yang, L. A. Herzenberg
    Pages 41-61

  5. The Important and Diverse Roles of Antibodies in the Host Response to Borrelia Infections

    • T. J. LaRocca, J. L. Benach
    Pages 63-103

  6. A Distinct Role for B1b Lymphocytes in T Cell-Independent Immunity

    • K. R. Alugupalli
    Pages 105-130

  7. Secretory Immunity Following Mutans Streptococcal Infection or Immunization

    • D. J. Smith, R. O. Mattos-Graner
    Pages 131-156

  8. Back Matter

    Pages 157-162
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Keywords

About this book

The importance of specific antibodies for the clearance of and long-term resistance to many infectious pathogens has long been appreciated. Moreover, the role in these processes of the different antibody heavy chain isotypes, each tailored to induce diverse effector pathways such as those mediated by complement and Fc receptors and to promote antibody localization in distinct regions of the body, is well established. Insights into the molecular mechanism of isotype class switching showed that during an immune response B cells could change the heavy chain of the antibody they produced, without influencing the structure and specificity of the antigen-binding variable regions of this antibody (Honjo 1983). More recently, the germinal center pathway of B cell development was elucidated, in which antibody variable regions undergo extensive structural alteration via hypermutation followed by stringent phenotypic selection (Berek 1992; Kelsoe 1995). Emerging from this pathway are memory B cells and long-lived antibody-forming cells that express antigen receptors and secrete antibodies, respectively, with increased affinity and specificity for the foreign antigen. Taken together, these findings led to a view of the acquisition of antibody-mediated resistance to infectious pathogens in mammals that involved extensive somatic matu- tion of antibody heavy and variable region structure and function during the immune response. This was in keeping with the concept that the B cell compartment comprises a major arm of the adaptive immune system. Such a view was reinforced by molecular analyses of antiviral antibody responses (Zinkernagel 1996).

Editors and Affiliations

  • Department of Microbiology and Immunology, Jefferson Medical College, Philadelphia, USA

    Tim Manser

Bibliographic Information

  • Book Title: Specialization and Complementation of Humoral Immune Responses to Infection

  • Editors: Tim Manser

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-540-73900-5

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 2008

  • Hardcover ISBN: 978-3-540-73899-2Published: 22 November 2007

  • Softcover ISBN: 978-3-642-09313-5Published: 30 November 2010

  • eBook ISBN: 978-3-540-73900-5Published: 31 December 2007

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: XII, 162

  • Topics: Immunology, Virology

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