Overview
- First book to look not exclusively at GABA receptors for the regulation of excitatory neurotransmission, but at all different types of inhibitory proteins
- Written by experts from around the world
Part of the book series: Results and Problems in Cell Differentiation (RESULTS, volume 44)
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Table of contents (12 chapters)
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Front Matter
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Back Matter
Keywords
About this book
Within the central and peripheral nervous systems of animals, including man, inhibition is crucial to counterbalance excitatory neurotransmission, which is predominantly mediated by glutamate and its receptors. Although, particularly in brain, much of this inhibition is provided by classical post-synaptic GABAA receptors, many other proteins and mechanisms regulate excitation. These exist both to "fine tune" neurotransmission and to prevent overexcitation that could lead to conditions such as epilepsy and excitotoxicity, which can result in cell death. This book reviews aspects of GABAA receptor function, as well as the properties of a variety of other important inhibitory proteins, such as GABAC receptors, G-protein coupled receptors (specifically, GABAB receptors, metabotropic glutamate receptors and neuropeptide receptors), glycine receptors, GABA transporters and potassium channels. In addition, the consequences of mutations that disrupt the regulation of excitatory neurotransmission, and efforts to target the GABAergic system for therapeutic benefit, are discussed.
Bibliographic Information
Book Title: Inhibitory Regulation of Excitatory Neurotransmission
Editors: Mark G. Darlison
Series Title: Results and Problems in Cell Differentiation
DOI: https://doi.org/10.1007/978-3-540-72602-9
Publisher: Springer Berlin, Heidelberg
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer-Verlag Berlin Heidelberg 2008
Hardcover ISBN: 978-3-540-72601-2Published: 02 October 2007
Softcover ISBN: 978-3-642-09162-9Published: 22 November 2010
eBook ISBN: 978-3-540-72602-9Published: 07 September 2007
Series ISSN: 0080-1844
Series E-ISSN: 1861-0412
Edition Number: 1
Number of Pages: XVI, 248
Topics: Neurobiology, Cell Biology, Neurosciences, Animal Physiology, Biochemistry, general