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  • Book
  • © 2007

Chromosomal Alterations

Methods, Results and Importance in Human Health

  • Up-to-date overview on the use of cytogenetics in human population monitoring, in biological dosimetry, in radiation accidents, in astronauts and as a predictive measure of cancer

  • Written by respected experts

  • Includes supplementary material: sn.pub/extras

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Table of contents (31 chapters)

  1. Front Matter

    Pages i-xxiv
  2. Human Chromosomes: Structural and Functional Aspects

    • Heidemarie Neitzel, Marc Trimborn
    Pages 1-20
  3. DNA Lesions Induced by Ionizing Radiation

    • Clemens von Sonntag
    Pages 21-38
  4. Effects of Ultraviolet Radiation on DNA

    • Jürgen Kiefer
    Pages 39-53
  5. Backup Pathways of Nonhomologous End Joining May Have a Dominant Role in the Formation of Chromosome Aberrations

    • George Iliakis, Wenqi Wu, Minli Wang, Georgia I. Terzoudi, Gabriel E. Pantelias
    Pages 67-85
  6. DNA Methylation Damage: Formation, Repair and Biological Consequences

    • Markus Christmann, Wynand P. Roos, Bernd Kaina
    Pages 99-121
  7. Comet Assay

    • Wolfgang-Ulrich Müller
    Pages 161-176
  8. Origin of Chromosome Aberrations: Mechanisms

    • Peter E Bryant
    Pages 177-199
  9. Chromatin Structure and the Formation of Chromosomal Alterations

    • Gregor Kreth, Christoph Cremer
    Pages 201-209
  10. Role of Chromatin Structure and Activity in the Induction of Chromosomal Aberrations

    • Wilner Martínez-López, María Vittoria Di Tomaso, Leticia Méndez-Acuña, María Mühlmann
    Pages 211-224
  11. A Biomedical Perspective of Telomere Structure and Function

    • Máximo E. Drets, Federico F. Santiñaque
    Pages 225-240
  12. In Vivo Rodent Micronucleus Assay

    • Makoto Hayashi
    Pages 257-270
  13. Sister-Chromatid Exchanges

    • Andrzej Wojcik, Günter Obe
    Pages 271-283
  14. Fluorescence in Situ Hybridisation

    • Ilse Chudoba
    Pages 285-299

About this book

Cytogenetics is a very important research tool in basic and applied research. The uses of cytogenetics in human-population monitoring, in biological dosimetry in radiation accidents and in astronauts and as a predictive measure of cancer are topics discussed in this book. The book will help the reader to better understand cytogenetics and the intricacies of the methodology. The different methods of fluorescence in situ hybridization are discussed and the results achieved are presented. The book provides a comprehensive review of basic and applied aspects of cytogenetics and therefore will be of interest to all who are interested in chromosomes and their alterations by different types of mutagens, including chemical mutagens and ionizing and nonionizing radiation, with special reference to electromagnetic fields.

Editors and Affiliations

  • Teltow, Germany

    Günter Obe

  • Department of Radiation Oncology, The University of Texas, Health Science Center, San Antonio, USA

    Vijayalaxmi

About the editors

Both editors have a year long experience in cytogenetic research and published many papers in peer reviewed journals on different topics of cytogenetics.

Bibliographic Information

Buy it now

Buying options

eBook USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access