Overview
- Covers one of the most important topics in modern biology: recombination
- Summarize all existing views on the topic and to put them into context
- In-depth and up-to-date analysis of the chapter topics, written by international experts
- Includes supplementary material: sn.pub/extras
Part of the book series: Topics in Current Genetics (TCG, volume 17)
Access this book
Tax calculation will be finalised at checkout
Other ways to access
Table of contents (34 chapters)
-
Front Matter
Keywords
About this book
Genetic recombination is an important process involved in shaping the genetic make up of progeny. Increasingly, it has become evident that recombination is a DNA repair pathway crucial during DNA replication in vegetatively growing cells. It plays a critical role in preserving the integrity of the genome by mediating the repair of DNA damage, which can occur during normal cellular metabolism as a result of oxidative stress, transcription, replication fork stalling or breakdown, or after the exposure to DNA damaging agents. Until recently, much of our knowledge on the mechanisms of genetic recombination has come from studies of prokaryotic and simple eukaryotic fungal systems. However, these studies have now been significantly extended to mammals, such that a comparative picture of the general factors and mechanisms of genetic recombination is beginning to emerge. Detailed genetic and biochemical studies have led to the isolation and characterization of many of the recombination-repair proteins in E. coli and S. cerevisiae, which in turn has led to the identification of homologues in human cells. The link between recombination defects and recombination proteins in a number of tumors as well as in human hereditary syndromes makes genetic recombination a cellular process of key importance not only in basic biology but also in biomedical studies.
Editors and Affiliations
Bibliographic Information
Book Title: Molecular Genetics of Recombination
Editors: Andrés Aguilera, Rodney Rothstein
Series Title: Topics in Current Genetics
DOI: https://doi.org/10.1007/978-3-540-71021-9
Publisher: Springer Berlin, Heidelberg
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer-Verlag Berlin Heidelberg 2007
Hardcover ISBN: 978-3-540-71020-2Published: 03 April 2007
Softcover ISBN: 978-3-642-09005-9Published: 19 November 2010
eBook ISBN: 978-3-540-71021-9Published: 24 April 2007
Series ISSN: 1610-2096
Series E-ISSN: 1610-6970
Edition Number: 1
Number of Pages: XXIV, 524
Topics: Cell Biology, Biochemistry, general, Microbial Genetics and Genomics, Plant Genetics and Genomics, Animal Genetics and Genomics