Overview
- Editors:
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Jack E. Henningfield
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Pinney Associates, Bethesda, USA
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Edythe D. London
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UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, USA
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Sakire Pogun
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Center for Brain Research, Bornova, Ege University, Izmir, Turkey
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Table of contents (18 chapters)
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Nicotine and Tobacco Consumption: Measurement and Trends
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- Neal L. Benowitz, Janne Hukkanen, Peyton Jacob III
Pages 29-60
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- Mirjana V. Djordjevic, Kelly A. Doran
Pages 61-82
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Nicotine Pharmacology and Mechanisms of Action
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- Allan C. Collins, Outi Salminen, Michael J. Marks, Paul Whiteaker, Sharon R. Grady
Pages 85-112
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- Allen Azizian, John Monterosso, Joseph O'Neill, Edythe D. London
Pages 113-143
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- Anil Sharma, Arthur L. Brody
Pages 145-171
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- Jacques Barik, Susan Wonnacott
Pages 173-207
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- Jill C. Mwenifumbo, Rachel F. Tyndale
Pages 235-259
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- Sakire Pogun, Gorkem Yararbas
Pages 261-291
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Nicotine Psychopharmacology
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- Janice W. Smith, Ian P. Stolerman
Pages 295-333
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- Bernard Le Foll, Steven R. Goldberg
Pages 335-367
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- David H. Malin, Pilar Goyarzu
Pages 401-434
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Approaches, Challenges, and Experience in Assessing Free Nicotine
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- David L. Ashley, James F. Pankow, Ameer D. Tavakoli, Clifford H. Watson
Pages 437-456
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- Geoffrey Ferris Wayne, Carrie M. Carpenter
Pages 457-485
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- Reginald V. Fant, August R. Buchhalter, Albert C. Buchman, Jack E. Henningfield
Pages 487-510
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- Jack E. Henningfield, Mitch Zeller
Pages 511-534
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Back Matter
Pages 535-544
About this book
The fact that tobacco ingestion can affect how people feel and think has been known for millennia, placing the plant among those used spiritually, honori?cally, and habitually (Corti 1931; Wilbert 1987). However, the conclusion that nicotine - counted for many of these psychopharmacological effects did not emerge until the nineteenth century (Langley 1905). This was elegantly described by Lewin in 1931 as follows: “The decisive factor in the effects of tobacco, desired or undesired, is nicotine. . . ”(Lewin 1998). The use of nicotine as a pharmacological probe to und- stand physiological functioning at the dawn of the twentieth century was a landmark in the birth of modern neuropharmacology (Limbird 2004; Halliwell 2007), and led the pioneering researcher John Langley to conclude that there must exist some “- ceptive substance” to explain the diverse actions of various substances, including nicotine, when applied to muscle tissue (Langley 1905). Research on tobacco and nicotine progressed throughout the twentieth century, but much of this was from a general pharmacological and toxicological rather than a psychopharmacological perspective (Larson et al. 1961). There was some attention to the effects related to addiction, such as euphoria (Johnston 1941), tolerance (Lewin 1931), and withdrawal (Finnegan et al. 1945), but outside of research supported by the tobacco industry, addiction and psychopharmacology were not major foci for research (Slade et al. 1995; Hurt and Robertson 1998; Henning?eld et al. 2006; Henning?eld and Hartel 1999; Larson et al. 1961).
Editors and Affiliations
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Pinney Associates, Bethesda, USA
Jack E. Henningfield
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UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, USA
Edythe D. London
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Center for Brain Research, Bornova, Ege University, Izmir, Turkey
Sakire Pogun