Radiotherapy for Non-Malignant Disorders

1. Front Matter

   Pages I-XV

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2. General Background

   1. Front Matter

      Pages 1-1

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   2. Radiobiological Principles

      • Klaus-Rüdiger Trott, Friedrich-Hugo Kamprad, Guido Hildebrandt

      Pages 3-27

   3. Side Effects and Long-Term Risks from Radiotherapy of Non-malignant Diseases

      • Klaus-Rüdiger Trott, Friedrich-Hugo Kamprad

      Pages 29-43

   4. Risk Assessment and Carcinogenesis Modelling

      • Johann J. Broerse, J. T. M. Jansen, J. Zoetelief

      Pages 45-58

   5. Radiophysical Principles

      • Ulrich Wolf, Tilo Wiezorek

      Pages 59-87

   6. Clinical Principles

      • Michael Heinrich Seegenschmiedt, Ulrich Schäfer

      Pages 89-119

   7. Irradiation of Non-malignant Diseases: An International Survey

      • Jan Willem Hendrik Leer, Paul van Houtte, Jaap Davelaar

      Pages 121-132

   8. Patterns-of-Care Study for Non-malignant Diseases in Germany

      • Michael Heinrich Seegenschmiedt, Oliver Micke, the German Cooperative Group on Benign Diseases (GCG-BD)

      Pages 133-143

3. Skin and Soft Tissue Disorders

   1. Front Matter

      Pages 145-145

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   2. Non-malignant Skin Disorders: Tumors, Hyperplasia, Dermatoses

      • Renato G. Panizzon, Rene O. Mirimanoff, Michael Heinrich Seegenschmiedt

      Pages 147-159

   3. Morbus Dupuytren/Morbus Ledderhose

      • Michael Heinrich Seegenschmiedt

      Pages 161-191

   4. Pronie’s Disease

      • Luca Incrocci

      Pages 193-207

   5. Keloids and Hypertrophie Scars

      • Benjamin Guíx, Augusto Andrés, Pere Salort, José Ignacio Tello, IvÁn Henríquez, José Antonio Lejärcegui et al.

      Pages 209-224

   6. Aggressive Fibromatosis/Desmoid Tumors

      • Oliver Micke, Hans T. Eich, Frank Bruns, Jürgen Heide, Georg Gosheger, Michael H. Seegenschmiedt

      Pages 225-234

4. Bone and Joint Disorders

   1. Front Matter

      Pages 235-235

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   2. Orthopaedic Examination, Tests and Clinical Scores

      • Oliver Micke, Michael Heinrich Seegenschmiedt

      Pages 237-259

   3. Rotator Cuff Syndrome (RCS)

      • Boris Adamietz

      Pages 261-279

   4. Humeral Epicondylopathia (HEP), Lateral and Medial Humeral Epicondylitis

      • Michael Heinrich Seegenschmiedt, Felicitas Guntrum, Hartmut Krahl

      Pages 281-294

   5. Calcaneodynia: Plantar and Dorsal Heel Spur/Heel Spur Syndrome

      • Oliver Micke, Antje Ernst-Stecken, Ralph Mücke, Michael Heinrich Seegenschmiedt

      Pages 295-315

Non-malignant, or "benign", diseases can be successfully treated using ionizing rad- tion technologies. It was first proposed in 1898 by Sokoloff, who reported the analgesic effects of radiotherapy for painful rheumatoid arthritis. Since then, the use of these techniques for painful muscle-skeletal diseases has gained acceptance particularly in Europe but is still carried out actively in the United States. Non-malignant diseases that are amenable to radiotherapy can be classified as inflammatory, degenerative, hype- roliferative, functional, or other disorders. However, the topographic and morphologic considerations are more relevant. Even though radiation therapy for "benign" diseases has not been pursued actively since the 1950s, more recent interest has dictated that it can be a very effective treatment modality. The use of radiotherapy can be justified for invasive and aggressive growth such as that seen with desmoids, for cosmetic d- figurations and functional loss as seen with keloids or endocrine orbitopathy, or for life-threatening complications such as hepatic hemangiomas or juvenile angiofibromas that occur in children or adolescents. Many of the non-malignant diseases can have a major and lasting effect on quality of life by causing pain or other serious symptoms, particularly when other methods of treatment are unavailable, have failed, or may induce more side effects. It is not generally the first choice of therapy in these non-malignant diseases, but it is acceptable as defined. The book edited by Seegenschmiedt et al.

• Tumor
• aneurysm
• bone
• brain
• carcinogenesis
• clinical application
• dermatose
• eye
• knee
• radiation
• radiation therapy
• radiotherapy
• spinal cord
• synovectomy
• therapy

From the reviews:

"This all-inclusive book addressing benign conditions that can be treated with radiation covers first principles for the radiobiology and physics associated with treatment and its delivery and then details the conditions, treatment options, and techniques of therapy. … the book is designed for practitioners and all medical specialists, particularly radiation oncologists, orthopedists, surgeons, and ophthalmologists. … an important addition to the literature for radiation oncologists as well as for a broad range of specialists. This is an outstanding resource for residents and clinicians … ." (Ann Pittier, Doody’s Review Service, May, 2008)

"The chapter in the textbook entitled Radiotherapy for Non-Malignant Disorders that covers the treatment of nonmalignant central nervous system (CNS) disorders by using ionizing radiation is a well-written, concise, and organized accounting of the current state of the art for physicians and residents in neurosurgery, neurology, neuro-oncology, medical physics, and radiation oncology. … is an excellent reference guide for any clinical member of the treatment team for these diseases." (American Journal of Neuroradiology, Vol. 29, November-December, 2008)

• Department of Radiation Oncology and Therapeutic Radiology, Alfried-Krupp-Hospital, Essen, Germany

  Michael Heinrich Seegenschmiedt

• Strahlenklinik Klinikum Duisburg, Duisburg, Germany

  Hans-Bruno Makoski

• Department of Radiation Biology, St. Bartolomew’s Medical College, London, UK

  Klaus-Rüdiger Trott

• Hylda Cohn/American Cancer Society, USA

  Luther W. Brady

• College of Medicine, Drexel University, Philadelphia, USA

  Luther W. Brady

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