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Bacterial Protein Toxins

  • Book
  • © 2000

Overview

Editors:
  1. Klaus Aktories

    1. Institut für Pharmakologie und Toxikologie, Albert-Ludwigs-Universität Freiburg, Freiburg i. Br., Germany

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  2. Ingo Just

    1. Institut für Pharmakologie und Toxikologie, Albert-Ludwigs-Universität Freiburg, Freiburg i. Br., Germany

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Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 145)

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Table of contents (28 chapters)

  1. Front Matter

    Pages I-XXXII
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  2. Uptake of Protein Toxins Acting Inside Cells

    • S. Olsnes, J. Wesche, P. Ø. Falnes
    Pages 1-19

  3. Common Features of ADP—Ribosyltransferases

    • V. Masignani, M. Pizza, R. Rappuoli
    Pages 21-44

  4. Diphtheria Toxin and the Diphtheria-Toxin Receptor

    • T. Umata, K. D. Sharma, E. Mekada
    Pages 45-66

  5. Pseudomonas aeruginosa Exotoxin A: Structure/Function, Production, and Intoxication of Eukaryotic Cells

    • S. E. H. West
    Pages 67-89

  6. Diphtheria-Toxin-Based Fusion-Protein Toxins Targeted to the Interleukin-2 Receptor: Unique Probes for Cell Biology and a New Therapeutic Agent for the Treatment of Lymphoma

    • J. R. Murphy, J. C. Vanderspek
    Pages 91-107

  7. Structure and Function of Cholera Toxin and Related Enterotoxins

    • F. van den Akker, E. Merritt, W. G. J. Hol
    Pages 109-131

  8. Mechanism of Cholera Toxin Action: ADP-Ribosylation Factors as Stimulators of Cholera Toxin-Catalyzed ADP-Ribosylation and Effectors in Intracellular Vesicular Trafficking Events

    • W. A. Patton, N. Vitale, J. Moss, M. Vaughan
    Pages 133-165

  9. Pertussis Toxin: Structure—Function Relationship

    • C. Locht, R. Antoine, A. Veithen, D. Raze
    Pages 167-185

  10. Pertussis Toxin as a Pharmacological Tool

    • B. Nürnberg
    Pages 187-206

  11. Clostridium Botulinum C3 Exoenzyme and C3-Like Transferases

    • K. Aktories, H. Barth, I. Just
    Pages 207-233

  12. Pseudomonas aeruginosa Exoenzyme S, a Bifunctional Cytotoxin Secreted by a Type-III Pathway

    • J. T. Barbieri, D. W. Frank
    Pages 235-251

  13. Structure and Function of Actin-Adenosine-Diphosphate-Ribosylating Toxins

    • I. Ohishi
    Pages 253-273

  14. Molecular Biology of Actin-ADP-Ribosylating Toxins

    • M. R. Popoff
    Pages 275-306

  15. Molecular Mechanisms of Action of the Large Clostridial Cytotoxins

    • I. Just, F. Hofmann, K. Aktories
    Pages 307-331

  16. Molecular Biology of Large Clostridial Toxins

    • J. S. Moncrief, D. M. Lyerly, T. D. Wilkins
    Pages 333-359

  17. The Cytotoxic Necrotizing Factor 1 from Escherichia Coli

    • P. Boquet, C. Fiorentini
    Pages 361-384

  18. Shiga Toxins of Shigella dysenteriae and Escherichia coli

    • A. R. Melton-Celsa, A. D. O’Brien
    Pages 385-406

  19. Clostridial Neurotoxins

    • H. Bigalke, L. F. Shoer
    Pages 407-443

  20. Anthrax Toxin

    • S. H. Leppla
    Pages 445-472
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Keywords

About this book

In recent years remarkable progress has been accomplished with respect to our knowledge about bacterial protein toxins. This refers especially to structural aspects of protein toxins but also holds true for genetics, molecular biology and biochemical mechanisms underlying the action of toxins. This volume covers the very current and exciting aspects of up-to-date bacterial toxicology and comprehensively reviews the most important bacterial protein toxins such as the intracellular acting toxins which exhibit enzyme activity, as well as those toxins that interact with cell plasma membranes by damaging the membranes (pore formation) or stimulating cell receptors (superantigens). This is the most current reference work on these important bacterial protein toxins, which are presented from the point of view of different disciplines such as pharmacology, microbiology, cell biology and protein chemistry.

Editors and Affiliations

  • Institut für Pharmakologie und Toxikologie, Albert-Ludwigs-Universität Freiburg, Freiburg i. Br., Germany

    Klaus Aktories, Ingo Just

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