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Proteases as Targets for Therapy

  • Book
  • © 2000

Overview

Editors:
  1. Klaus Helm

    1. Max-von-Pettenkofer Institut für medizinische Mikrobiologie, LM Universität, München, Germany

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  2. Bruce D. Korant

    1. DuPont Pharmaceutical Co Research and Development, Wilmington, USA

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  3. John C. Cheronis

    1. Drug Discovery and Development, Source Precision Medicine, Boulder, USA

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Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 140)

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Table of contents (20 chapters)

  1. Front Matter

    Pages I-XXVIII
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  3. Other Viral (Non-HIV) Protease Inhibitors

    1. Front Matter

      Pages 73-73
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    2. The Proteinases Encoded by Hepatitis C Virus as Therapeutic Targets

      • C. Steinkühler, U. Koch, R. De Francesco, A. Pessi
      Pages 75-94

    3. The Human Herpes-Virus Proteases

      • C. E. Dabrowski, X. Qiu, S. S. Abdel-Meguid
      Pages 95-115

    4. The 3C Proteinases of Picornaviruses and Other Positive-Sense, Single-Stranded RNA Viruses

      • E. M. Bergmann, M. N. G. James
      Pages 117-143

    5. Adenovirus Proteinase-Antiviral Target for Triple-Combination Therapy on a Single Enzyme: Potential Inhibitor-Binding Sites

      • W. F. Mangel, D. L. Toledo, M. T. Brown, J. Ding, R. M. Sweet, D. L. Barnard et al.
      Pages 145-158

    6. Proteinases as Virulence Factors in Bacterial Diseases and as Potential Targets for Therapeutic Intervention with Proteinase Inhibitors

      • J. Potempa, J. Travis
      Pages 159-188

    7. Parasite Proteases as Targets for Therapy

      • J. H. McKerrow, C. R. Caffrey, J. P. Salter
      Pages 189-204

  4. (Non-Viral) Proteases Involved in Diseases

    1. Front Matter

      Pages 205-205
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    2. Host Proteinases as Targets for Therapeutic Intervention

      • J. C. Cheronis
      Pages 207-219

    3. The Role of Metalloprotease Inhibitors in Cancer and Chronic Inflammatory Diseases

      • H. S. Rasmussen, K. P. Lynch
      Pages 221-234

    4. The Tumor Necrosis Factor-α Converting Enzyme

      • J. D. Becherer, M. H. Lambert, R. C. Andrews
      Pages 235-258

    5. Serine Elastases in Inflammatory and Vascular Diseases

      • J. C. Cheronis, M. Rabinovitch
      Pages 259-275

    6. Inhibitors of Thrombin and Factor Xa

      • A. H. Schmaier
      Pages 277-299

    7. Inhibitors of Papain-Like Cysteine Peptidases in Cancer

      • R. Shridhar, B. F. Sloane, D. Keppler
      Pages 301-328
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Keywords

Editors and Affiliations

  • Max-von-Pettenkofer Institut für medizinische Mikrobiologie, LM Universität, München, Germany

    Klaus Helm

  • DuPont Pharmaceutical Co Research and Development, Wilmington, USA

    Bruce D. Korant

  • Drug Discovery and Development, Source Precision Medicine, Boulder, USA

    John C. Cheronis

Bibliographic Information

  • Book Title: Proteases as Targets for Therapy

  • Editors: Klaus Helm, Bruce D. Korant, John C. Cheronis

  • Series Title: Handbook of Experimental Pharmacology

  • DOI: https://doi.org/10.1007/978-3-642-57092-6

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2000

  • Hardcover ISBN: 978-3-540-66118-4Published: 08 December 1999

  • Softcover ISBN: 978-3-642-63023-1Published: 10 October 2012

  • eBook ISBN: 978-3-642-57092-6Published: 06 December 2012

  • Series ISSN: 0171-2004

  • Series E-ISSN: 1865-0325

  • Edition Number: 1

  • Number of Pages: XXVIII, 410

  • Number of Illustrations: 67 b/w illustrations, 13 illustrations in colour

  • Topics: Pharmacology/Toxicology, Biochemistry, general, Molecular Medicine

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