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Vogel and Motulsky's Human Genetics

Problems and Approaches

  • Book
  • © 1997

Overview

Authors:
  1. Friedrich Vogel

    1. Institut für Humangenetik und Anthropologie, Heidelberg, Germany

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  2. Arno G. Motulsky

    1. Division of Medical Genetics, School of Medicine, University of Washington, Seattle, USA

    View author publications

    You can also search for this author in PubMed   Google Scholar

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Table of contents (20 chapters)

  1. Front Matter

    Pages I-XXXVI
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  2. Introduction

    • Friedrich Vogel, Arno G. Motulsky
    Pages 1-9

  3. History of Human Genetics

    • Friedrich Vogel, Arno G. Motulsky
    Pages 11-23

  4. The Human Genome: Chromosomes

    • Friedrich Vogel, Arno G. Motulsky
    Pages 25-82

  5. The Human Genome: Genes and DNA

    • Friedrich Vogel, Arno G. Motulsky
    Pages 83-127

  6. Formal Genetics of Humans: Modes of Inheritance

    • Friedrich Vogel, Arno G. Motulsky
    Pages 129-162

  7. Formal Genetics of Humans: Linkage Analysis and Gene Clusters

    • Friedrich Vogel, Arno G. Motulsky
    Pages 163-193

  8. Formal Genetics of Humans: Multifactorial Inheritance and Common Diseases

    • Friedrich Vogel, Arno G. Motulsky
    Pages 195-256

  9. Gene Action: Genetic Diseases

    • Friedrich Vogel, Arno G. Motulsky
    Pages 257-360

  10. Gene Action: Developmental Genetics

    • Friedrich Vogel, Arno G. Motulsky
    Pages 361-383

  11. Mutation: Spontaneous Mutation in Germ Cells

    • Friedrich Vogel, Arno G. Motulsky
    Pages 385-430

  12. Mutation: Somatic Mutation, Cancer, and Aging

    • Friedrich Vogel, Arno G. Motulsky
    Pages 431-456

  13. Mutation: Induction by Ionizing Radiation and Chemicals

    • Friedrich Vogel, Arno G. Motulsky
    Pages 457-493

  14. Population Genetics: Description and Dynamics

    • Friedrich Vogel, Arno G. Motulsky
    Pages 495-548

  15. Population Genetics: Consanguinity, Genetic Drift

    • Friedrich Vogel, Arno G. Motulsky
    Pages 549-582

  16. Human Evolution

    • Friedrich Vogel, Arno G. Motulsky
    Pages 583-621

  17. Behavioral Genetics: Research Strategies and Examples

    • Friedrich Vogel, Arno G. Motulsky
    Pages 623-691

  18. Behavioral Genetics: Affective Disorders and Schizophrenia

    • Friedrich Vogel, Arno G. Motulsky
    Pages 693-704

  19. Behavioral Genetics: Differences Between Populations

    • Friedrich Vogel, Arno G. Motulsky
    Pages 705-710

  20. Genetic Counseling and Prenatal Diagnosis. Human Genome Project

    • Friedrich Vogel, Arno G. Motulsky
    Pages 711-732
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Keywords

About this book

The first two editions of this book, published in 1979 and in 1986, were well re­ ceived by the scientific community. Translations into Italian, Japanese, and Rus­ sian suggest that this book was regarded useful in many parts of the world. Mean­ while, human genetics has seen dramatic developments, and the "molecular revo­ lution" has attracted thousands of scientists, including many molecular biologists, to this field. About 3700 human genes have already been mapped to chromosomal sites. Many such genes have been cloned, and the various mutations causing dis­ ease have been identified. Novel mutational mechanisms such as expanded trinu­ cleotide repeats have been discovered in conditions such as Huntington's disease and the fragile X syndrome of mental retardation. Gene action now can often be elucidated by studying the pathway from gene to phenotype following positional cloning rather than working in the opposite direction, as was customarily done be­ fore the tools of "new genetics" were available. In an increasing number of genetic diseases, the pathogenic mechanisms have been elucidated with positive conse­ quences for prevention and treatment. It therefore became necessary to rewrite al­ most completely major portions of this book. These developments are now making genetics arguably the leading basic science for medicine, as well as a recognized medical speciality. But all these changes do not mean that the entire framework of human genetics had to be reconstructed.

Authors and Affiliations

  • Institut für Humangenetik und Anthropologie, Heidelberg, Germany

    Friedrich Vogel

  • Division of Medical Genetics, School of Medicine, University of Washington, Seattle, USA

    Arno G. Motulsky

Bibliographic Information

  • Book Title: Vogel and Motulsky's Human Genetics

  • Book Subtitle: Problems and Approaches

  • Authors: Friedrich Vogel, Arno G. Motulsky

  • DOI: https://doi.org/10.1007/978-3-662-03356-2

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1997

  • eBook ISBN: 978-3-662-03356-2Published: 17 April 2013

  • Edition Number: 3

  • Number of Pages: LXXII, 851

  • Topics: Biochemistry, general, Human Genetics

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