Editors:
- First book to highlight the medical implications, i.e. diseases, caused by alternative splicing
- Outlines possible targets for therapy
- Written by internationally reknown experts
- Includes supplementary material: sn.pub/extras
Part of the book series: Progress in Molecular and Subcellular Biology (PMSB, volume 44)
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Table of contents (10 chapters)
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Front Matter
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Back Matter
About this book
Splicing of primary RNA transcript, i.e. removal of introns and joining of exons to produce mature mRNAs competent for translation into proteins, is a quasi-systematic step of gene expression in higher organisms. However, this process is not unequivocal but can follow alternate pathways. Alternative splicing of a given transcript can therefore yield several distinct mRNAs encoding as many different proteins. Its full biological significance has not been appreciated until it was recognized that alternative splicing is so general as to affect about 75% of all human genes. Therefore, alternative splicing not only vastly increases protein diversity but also offers numerous opportunities for aberrant splicing events with pathological consequences.
Editors and Affiliations
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Institute of Molecular Genetics of Montpellier, France
Philippe Jeanteur
Bibliographic Information
Book Title: Alternative Splicing and Disease
Editors: Philippe Jeanteur
Series Title: Progress in Molecular and Subcellular Biology
DOI: https://doi.org/10.1007/978-3-540-34449-0
Publisher: Springer Berlin, Heidelberg
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer-Verlag Berlin Heidelberg 2006
Hardcover ISBN: 978-3-540-34448-3Published: 03 August 2006
Softcover ISBN: 978-3-642-07081-5Published: 30 November 2010
eBook ISBN: 978-3-540-34449-0Published: 04 October 2006
Series ISSN: 0079-6484
Series E-ISSN: 2197-8484
Edition Number: 1
Number of Pages: XII, 257
Number of Illustrations: 24 b/w illustrations, 2 illustrations in colour
Topics: Cell Biology, Molecular Medicine, Biochemistry, general