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Analgesia

  • Book
  • © 2007

Overview

Editors:
  1. Christoph Stein

    1. Department of Anesthesiology and Critical Care Medicine Charité — Campus Benjamin Franklin, Free University Berlin, Berlin, Germany

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Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 177)

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Table of contents (15 chapters)

  1. Front Matter

    Pages I-IX
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  2. Introduction

    1. Front Matter

      Pages 1-1
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    2. Peripheral and Central Mechanisms of Pain Generation

      • H. -G. Schaible
      Pages 3-28

  3. Drugs in Clinical Use

    1. Front Matter

      Pages 29-29
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    2. Opioids

      • C. Zöllner, C. Stein
      Pages 31-63

    3. Antipyretic Analgesics: Nonsteroidal Antiinflammatory Drugs, Selective COX-2 Inhibitors, Paracetamol and Pyrazolinones

      • B. Hinz, K. Brune
      Pages 65-93

    4. Local Anesthetics

      • F. Yanagidate, G. R. Strichartz
      Pages 95-127

    5. Serotonin Receptor Ligands: Treatments of Acute Migraine and Cluster Headache

      • P. J. Goadsby
      Pages 129-143

    6. Anti-convulsants and Anti-depressants

      • A. H. Dickenson, J. Ghandehari
      Pages 145-177

  4. Compounds in Preclinical Development

    1. Front Matter

      Pages 179-179
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    2. Neuropeptide and Kinin Antagonists

      • R. G. Hill, K. R. Oliver
      Pages 181-216

    3. Glutamate Receptor Ligands

      • V. Neugebauer
      Pages 217-249

    4. Adrenergic and Cholinergic Compounds

      • R. D. Sanders, M. Maze
      Pages 251-264

    5. Cannabinoids and Pain

      • I. J. Lever, A. S. C. Rice
      Pages 265-306

  5. Future Targets in Analgesia Research

    1. Front Matter

      Pages 307-307
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    2. Adenosine and ATP Receptors

      • J. Sawynok
      Pages 309-328

    3. Ion Channels in Analgesia Research

      • J. N. Wood
      Pages 329-358

    4. Protein Kinases as Potential Targets for the Treatment of Pathological Pain

      • R. -R. Ji, Y. Kawasaki, Z. -Y. Zhuang, Y. -R. Wen, Y. -Q. Zhang
      Pages 359-389

  6. Pain Management Beyond Pharmacotherapy

    1. Front Matter

      Pages 391-391
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    2. Placebo and Endogenous Mechanisms of Analgesia

      • F. Benedetti
      Pages 393-413
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Keywords

About this book

Analgesics are among the oldest drugs described, albeit not necessarily for medicinaluse. Forexample,theSumeriansisolatedopioids(probablyfortheir euphoric effects) in the third millennium b. c. and the use of willow bark (salicin) for fever was ?rst reported in the eighteenth century. Both types of drugs are still in use, but today they are supplemented by a wide array of substances ranging from antidepressants to ion channel blockers. Not all of theseareprescribedbyphysicians. Manycompoundsaresoldoverthecounter and thus available to the public for self-medication. As a result, analgesics are also the most misused class of drugs and are the culprit for a multitude of healthproblemsdueto untoward sideeffects. Thisvolumeattemptstosummarizethecurrentstateofknowledgeonme- anisms underlying the various effects of these drugs, their side effect pro?les, and their indications and contraindications in clinical use. It also gives - sights into current efforts to discover novel mechanisms underlying different types of pain generation and the resulting development of new modulating compounds. Theseefforts haveemergedmostlyas aconsequenceofthemore profound insights provided by molecular methods and of the now common use of animal models of pathological, rather than physiological, pain. These important issues are elaborated in the introductory chapter. In parallel, c- temporaryinterdisciplinarytreatmentapproacheshavetaughtusthatsomatic mechanisms alone cannot explain pain; it is an experience shaped as well by social context, memory, and other psychological phenomena. Thus, the book closes with two chapters putting pharmacological strategies into a broader perspective. All of these advancements culminate in the contemporary c- mon goal of developing mechanism-based rather thanempiric approaches to thetreatment ofpain.

Editors and Affiliations

  • Department of Anesthesiology and Critical Care Medicine Charité — Campus Benjamin Franklin, Free University Berlin, Berlin, Germany

    Christoph Stein

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