Solid-State Fermentation Bioreactors

1. Front Matter

   Pages I-XXXVIII

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2. Solid-State Fermentation Bioreactor Fundamentals: Introduction and Overview

   • David A. Mitchell, Marin Berovič, Nadia Krieger

   Pages 1-12

3. The Bioreactor Step of SSF: A Complex Interaction of Phenomena

   • David A. Mitchell, Marin Berovič, Montira Nopharatana, Nadia Krieger

   Pages 13-32

4. Introduction to Solid-State Fermentation Bioreactors

   • David A. Mitchell, Marin Berovič, Nadia Krieger

   Pages 33-44

5. Basics of Heat and Mass Transfer in Solid-State Fermentation Bioreactors

   • David A. Mitchell, Marin Berovič, Oscar F. von Meien, Luiz Fernando L. Luz Jr

   Pages 45-56

6. The Scale-up Challenge for SSF Bioreactors

   • David A. Mitchell, Oscar F. von Meien, Luiz Fernando L. Luz Jr, Marin Berovič

   Pages 57-64

7. Group I Bioreactors: Unaerated and Unmixed

   • David A. Mitchell, Nadia Krieger, Marin Berovič

   Pages 65-76

8. Group II Bioreactors: Forcefully-Aerated Bioreactors Without Mixing

   • David A. Mitchell, Penjit Srinophakun, Nadia Krieger, Oscar F. von Meien

   Pages 77-94

9. Group III: Rotating-Drum and Stirred-Drum Bioreactors

   • David A. Mitchell, Deidre M. Stuart, Matthew T. Hardin, Nadia Krieger

   Pages 95-114

10. Group IVa: Continuously-Mixed, Forcefully-Aerated Bioreactors

    • David A. Mitchell, Nadia Krieger, Marin Berovič, Luiz F. L. Luz Jr

    Pages 115-128

11. Group IVb: Intermittently-Mixed Forcefully-Aerated Bioreactors

    • David A. Mitchell, Oscar F. von Meien, Luiz F. L. Luz Jr, Nadia Krieger, J. Ricardo Pérez-Correa, Eduardo Agosin

    Pages 129-140

12. Continuous Solid-State Fermentation Bioreactors

    • Luis B. R. Sánchez, Morteza Khanahmadi, David A. Mitchell

    Pages 141-158

13. Approaches to Modeling SSF Bioreactors

    • David A. Mitchell, Luiz F. L. Luz Jr, Marin Berovič, Nadia Krieger

    Pages 159-178

14. Appropriate Levels of Complexity for Modeling SSF Bioreactors

    • David A. Mitchell, Luiz F. L. Luz Jr, Marin Berovič, Nadia Krieger

    Pages 179-190

15. The Kinetic Sub-model of SSF Bioreactor Models: General Considerations

    • David A. Mitchell, Nadia Krieger

    Pages 191-206

16. Growth Kinetics in SSF Systems: Experimental Approaches

    • David A. Mitchell, Nadia Krieger

    Pages 207-218

17. Basic Features of the Kinetic Sub-model

    • David A. Mitchell, Graciele Viccini, Lilik Ikasari, Nadia Krieger

    Pages 219-234

18. Modeling of the Effects of Growth on the Local Environment

    • David A. Mitchell, Nadia Krieger

    Pages 235-248

19. Modeling of Heat and Mass Transfer in SSF Bioreactors

    • David A. Mitchell, Oscar F. von Meien, Luiz F. L. Luz Jr, Marin Berovič

    Pages 249-264

20. Substrate, Air, and Thermodynamic Parameters for SSF Bioreactor Models

    • David A. Mitchell, Oscar F. von Meien, Luiz F. L. Luz Jr, Marin Berovič

    Pages 265-278

Although solid-state fermentation (SSF) has been practiced for many centuries in the preparation of traditional fermented foods, its application to newer products within the framework of modern biotechnology is relatively restricted. It was c- sidered for the production of enzymes in the early 1900s and for the production of penicillin in the 1940s, but interest in SSF waned with the advances in submerged liquid fermentation (SLF) technology. The current dominance of SLF is not s- prising: For the majority of fermentation products, it gives better yields and is e- ier to apply. It is notoriously difficult to control the fermentation conditions in SSF; these difficulties are already apparent at small scale in the laboratory and are exacerbated with increase in scale. However, there are particular circumstances and products for which SSF technology is appropriate. For example, a desire to reuse solid organic wastes from agriculture and food processing rather than simply discarding them leads naturally to the use of SSF. Further, some microbial pr- ucts, such as fungal enzymes and spores, amongst others, are produced in higher yields or with better properties in the environment provided by SSF systems. With recognition of this potential of SSF, a revival of interest began in the mid- 1970s. However, the theoretical base for SSF bioreactor technology only began to be established around 1990.

• Expression
• Fermentation
• Scale up
• applied microbiology
• bioreactor design
• biotechnology
• chemistry
• microbiology
• physical chemistry
• preparation
• processing
• solid state processing
• biochemical engineering

• Department of Biochemistry and Molecular Biology, Federal University of Paraná, Curitiba-PR, Brazil

  David A. Mitchell

• Department of Chemical, Biochemical and Environmental Engineering, University of Ljubljana, Ljubljana, Slovenia

  Marin Berovič

• Department of Chemistry, Federal University of Paraná, Curitiba-PR, Brazil

  Nadia Krieger

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