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Current Concepts in Autoimmunity and Chronic Inflammation

  • Book
  • © 2006

Overview

Editors:
  1. Andreas Radbruch

    1. Deutsches Rheumaforschungszentrum Berlin (DRFZ), Berlin, Germany

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  2. Peter E. Lipsky

    1. National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Discusses the complex ethiopathologies of autoimmune diseases
  • Explores the broad variety of cell types and genes involved
  • Shows how initiating factors in autoimmune disease can possibly be distinct from those that drive the chronic course of the disease
  • Explains that the importance of an individual factor can change during the course of the disease

Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 305)

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Table of contents (13 chapters)

  1. Front Matter

    Pages I-IX
    Download chapter PDF

  2. B Cell Tolerance—How to Make It and How to Break It

    • F. Melchers, A. R. Rolink
    Pages 1-23

  3. Breaking Ignorance: The Case of the Brain

    • H. Wekerle
    Pages 25-50

  4. Naturally Arising Foxp3-Expressing CD25+CD4+ Regulatory T Cells in Self-Tolerance and Autoimmune Disease

    • S. Sakaguchi, R. Setoguchi, H. Yagi, T. Nomura
    Pages 51-66

  5. Sex Hormones and SLE: Influencing the Fate of Autoreactive B Cells

    • J. F. G. Cohen-Solal, V. Jeganathan, C. M. Grimaldi, E. Peeva, B. Diamond
    Pages 67-88

  6. Innate (Over)immunity and Adaptive Autoimmune Disease

    • M. Recher, K. S. Lang
    Pages 89-104

  7. Can Unresolved Infection Precipitate Autoimmune Disease?

    • D. J. B. Marks, N. A. Mitchison, A. W. Segal, J. Sieper
    Pages 105-125

  8. The Systemic Autoinflammatory Diseases: Inborn Errors of the Innate Immune System

    • S. Brydges, D. L. Kastner
    Pages 127-160

  9. Inefficient Clearance of Dying Cells and Autoreactivity

    • U. S. Gaipl, A. Sheriff, S. Franz, L. E. Munoz, R. E. Voll, J. R. Kalden et al.
    Pages 161-176

  10. The Importance of T Cell Interactions with Macrophages in Rheumatoid Cytokine Production

    • F. M. Brennan, A. D. Foey, M. Feldmann
    Pages 177-194

  11. T Cell Activation as Starter and Motor of Rheumatic Inflammation

    • A. Skapenko, P. E. Lipsky, H. Schulze-Koops
    Pages 195-211

  12. Signalling Pathways in B Cells: Implications for Autoimmunity

    • T. Dörner, P. E. Lipsky
    Pages 213-240

  13. Immunological Memory Stabilizing Autoreactivity

    • R. A. Manz, K. Moser, G. -R. Burmester, A. Radbruch, F. Hiepe
    Pages 241-257

  14. Genetics of Autoimmune Diseases: A Multistep Process

    • M. Johannesson, M. Hultqvist, R. Holmdahl
    Pages 259-276

  15. Back Matter

    Pages 277-282
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Keywords

About this book

The immune system has been known to be capable of distinguishing self from non-self since the pioneering work of Paul Erhlich more than a century ago. Originally described in experiments studying blood transfusion comp- ibility, the principle of “horror autotoxicus” is still valid, although today the phenomenon is usually described in terms of tolerance or ignorance. A great deal has been learned about the various processes preventing self-reactivity normally. These include processes that operate during immune cell ontogeny and subsequently on reactivity of mature lymphocytes in the periphery. They encompass mechanisms that are intrinsic to potentially reactive lymphocytes and can result in central or peripheral deletion or the alteration of functional potential. In addition, there are in?uences that are extrinsic to potentially auto-reactive lymphocytes, including the function of regulatory cells, d- ferentiation state of antigen-presenting cells, availability of self-antigen, the cytokine and chemokine milieu, as well as the traf?cking patterns involved in generating productive immune interactions. It is clear that the immune system devotes a considerable effort to the avoidance of the development of potentially pathogenic self-reactivity. Despite this, the development of self-reactivity is relatively common. - though the development of autoimmune disease is less frequent, autoimmune diseases, such as rheumatoid arthritis, multiple sclerosis, systemic lupus e- thematosus, psoriasis, thyroiditis, and myasthenia gravis, are all too common, and can cause considerable morbidity and even mortality.

Editors and Affiliations

  • Deutsches Rheumaforschungszentrum Berlin (DRFZ), Berlin, Germany

    Andreas Radbruch

  • National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, USA

    Peter E. Lipsky

Bibliographic Information

  • Book Title: Current Concepts in Autoimmunity and Chronic Inflammation

  • Editors: Andreas Radbruch, Peter E. Lipsky

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/3-540-29714-6

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 2006

  • Hardcover ISBN: 978-3-540-29713-0Published: 05 April 2006

  • Softcover ISBN: 978-3-642-06745-7Published: 12 February 2010

  • eBook ISBN: 978-3-540-29714-7Published: 08 September 2006

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: IX, 282

  • Topics: Immunology

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