Signaling Pathways in Liver Diseases

Recent advances have carried hepatology to new frontiers. The increasing frequency with which steatotic and cirrhotic livers undergo surgery obliges liver surgeons and hepatologists to understand the molecular mechanisms at play in these situations. Comprehension of the signaling pathways participating in liver regeneration, hepatocellular apoptosis and ischemia/reperfusion injury is essential. This book serves as a source of information to facilitate the reading of the literature and the planning of trials. Translational medicine implies knowledge of the molecular targets of novel therapeutic strategies. It is our goal to stimulate more research that can lead to more exchanges between the laboratory, the clinical ward and the operating room.

• Apoptosis
• Hepatocyte
• Liver
• Liver Disease
• Surgery
• hepatology
• surgical oncology

From the reviews:

"The text extensively describes all the known intracellular pathways present in the liver and relevant to the pathophysiology of liver diseases. … The text has been well written and is accompanied by clear and appropriate photographs. … The list of references is very detailed … to enable the reader to approach any topic easily. … This is the first textbook to be directed mainly at young basic and clinical scientists, who are interested in deepening their understanding of intracellular signaling pathways involved in liver diseases." (C. Balsano, Digestive and Liver Disease, Vol. 38, 2006)

"This book of 35 chapters is written by an international selection of scientists and is organized in three parts. … This book contains an enormous amount of data. … The target group of this book is those starting research in liver disease. For them, but also for established scientists and surgeons with a specific interest in liver physiology and pathophysiology, this book would be of great value as a reference volume." (U. Haglund, British Journal of Surgery, Vol. 93 (1), 2006)

• Institut Klinische Pharmakologie, Universität Bern, Bern, Switzerland

  Jean-François Dufour

• Klinik für Viszeral- und Transplantationschirurgie, Universitätsspital Zürich, Zürich, Switzerland

  Pierre-Alain Clavien

Prof. J.-F. Dufour, hepatologist at the University of Bern, is internationally recognized for bridging basic science and clincial practice.

Prof. P.-A. Clavien, head of visceral surgery University Hospital Zürich, is a world renown investigator in the field of liver ischemia/reperfusion injury.

Prof. Clavien successfully lead multi-authored texts having already published 3 books as editor: 

Malignant Liver Tumors, Blackwell Science Inc., May 1999

Medical Care of the Liver Transplant Patient (Killenberg/Clavien), Blackwell Science Inc.

Diseases of the Gallbladder and Bile Ducts: Diagnosis and Treatment (Clavien/Baillie),Blackwell Science Inc.

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