Overview
First book to connect changes of gap junction proteins with disease
Brilliant color illustrations
Contributions by experienced authors
Includes supplementary material: sn.pub/extras
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Table of contents (12 chapters)
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Front Matter
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Back Matter
Keywords
About this book
Communication between cells via intercellular channels – gap junctions – appears essential to certain developmental processes and appropriate organ function. Gap Junctions in Development and Disease aims to describe the molecular events underlying impaired development and disease. Beginning with a comprehensive review of various mouse and human genes encoding the channel-forming connexins, later chapters describe several connexin mutations associated with human diseases such as hereditary deafness and female infertility. Erroneous signaling mediated by the interaction of mutant connexins with other proteins, thought to be responsible for dysfunction of organs such as heart, muscle, brain, skin, lens, placenta, and endocrine tissue in both mice and men, is also addressed.
Although the question of why some mutations in gap-junction proteins lead to specific phenotypes remains to be answered, the reviews in this book provide an intriguing insight into the future direction of this research field.
Editors and Affiliations
Bibliographic Information
Book Title: Gap Junctions in Development and Disease
Editors: Elke Winterhager
DOI: https://doi.org/10.1007/3-540-28621-7
Publisher: Springer Berlin, Heidelberg
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer-Verlag Berlin Heidelberg 2005
Hardcover ISBN: 978-3-540-26156-8Published: 19 July 2005
Softcover ISBN: 978-3-642-06559-0Published: 14 October 2010
eBook ISBN: 978-3-540-28621-9Published: 04 November 2005
Edition Number: 1
Number of Pages: XVII, 279
Number of Illustrations: 37 b/w illustrations, 10 illustrations in colour
Topics: Cell Biology, Molecular Medicine, Developmental Biology, Otorhinolaryngology, Reproductive Medicine, Dermatology