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Microbial Protein Toxins

  • Book
  • © 2005

Overview

Editors:
  1. Manfred J. Schmitt
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    You can also search for this editor in PubMed   Google Scholar

  2. Raffael Schaffrath
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    You can also search for this editor in PubMed   Google Scholar

  • Unique overview on the mode of action of protein toxins as well as on the strategic advantages toxin producers have for survival
  • Includes supplementary material: sn.pub/extras

Part of the book series: Topics in Current Genetics (TCG, volume 11)

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Table of contents (12 chapters)

  1. Front Matter

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  2. Diphtheria toxin, diphtheria-related fusion protein toxins, and the molecular mechanism of their action against eukaryotic cells

    • Ryan Ratts, John R. Murphy
    Pages 1-20

  3. Anthrax toxin and genetic aspects regulating its expression

    • Amy E. Tucker, Jimmy D. Ballard
    Pages 21-34

  4. Shiga toxins and their mechanisms of cell entry

    • Kirsten Sandvig, Sébastien Wälchli, Silje U. Lauvrak
    Pages 35-53

  5. Cholera toxin: mechanisms of entry into host cells

    • David E. Saslowsky, Michael Kothe, Wayne I. Lencer
    Pages 55-67

  6. ExoU: A cytotoxin delivered by the type III secretion system of Pseudomonas aeruginosa

    • Shira D.P. Rabin, Alan R. Hauser
    Pages 69-89

  7. Staphylococcal alpha-toxin

    • Sucharit Bhakdi, Iwan Walev, Matthias Husmann, Angela Valeva
    Pages 91-110

  8. S. cerevisiae K28 toxin – a secreted virus toxin of the A/B family of protein toxins

    • Susanne Leis, Jenny Spindler, Jochen Reiter, Frank Breinig, Manfred J. Schmitt
    Pages 111-132

  9. Kluyveromyces lactis zymocin and other plasmid-encoded yeast killer toxins

    • Raffael Schaffrath, Friedhelm Meinhardt
    Pages 133-155

  10. The Ustilago maydis killer toxins

    • Jeremy Bruenn
    Pages 157-174

  11. Zygocin – a monomeric protein toxin secreted by virus-infected Zygosaccharomyces bailii

    • Frank Weiler, Manfred J. Schmitt
    Pages 175-187

  12. Acidophilic structure and killing mechanism of the Pichia farinosa killer toxin SMKT

    • Chise Suzuki
    Pages 189-214

  13. Ricin: structure, synthesis, and mode of action

    • J. Michael Lord, Lynne M. Roberts
    Pages 215-233

  14. Back Matter

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Keywords

About this book

Since the initial establishment of Robert Koch’s postulates in the nineteenth century, microbial protein toxins have been recognized as a major factor of bacterial and fungal virulence. An increasing number of proteins produced and secreted by various bacteria, yeasts and plants are extremely toxic and most of them developed remarkably "intelligent" strategies to enter, to penetrate and to finally kill a eukaryotic target cell by modifying or blocking essential cellular components.

This book describes the strategies employed by protein toxins to render their pro- and eukaryotic producers a selective growth advantage over competitors. In providing an up-to-date overview on the mode of protein toxin actions, it accommodates biomedically and biologically relevant toxin model systems. As a result, it significantly broadens our perspective on biochemical architecture and molecular ploy behind the lethal principles of pro- and eukaryotic toxins.

Bibliographic Information

  • Book Title: Microbial Protein Toxins

  • Editors: Manfred J. Schmitt, Raffael Schaffrath

  • Series Title: Topics in Current Genetics

  • DOI: https://doi.org/10.1007/b94860

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2005

  • Hardcover ISBN: 978-3-540-23562-0Published: 10 December 2004

  • Softcover ISBN: 978-3-642-06254-4Published: 12 February 2010

  • eBook ISBN: 978-3-540-31455-4Published: 10 December 2004

  • Series ISSN: 1610-2096

  • Series E-ISSN: 1610-6970

  • Edition Number: 1

  • Number of Pages: XIV, 237

  • Number of Illustrations: 35 b/w illustrations, 6 illustrations in colour

  • Topics: Microbiology, Medical Microbiology, Biochemistry, general, Cell Biology

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