G-Protein-Coupled Receptor Dimers

1. Front Matter

   Pages i-xvii

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2. Introduction

   1. Front Matter

      Pages 1-1

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   2. Historical Perspectives: From Monomers to Dimers and Beyond, an Exciting Journey in the World of G Protein-Coupled Receptors

      • Mario Rossi, Roberto Maggio, Irene Fasciani, Marco Scarselli

      Pages 3-14

   3. The Use of Spatial Intensity Distribution Analysis to Examine G Protein-Coupled Receptor Oligomerization

      • Richard J. Ward, Sara Marsango, John D. Pediani, Graeme Milligan

      Pages 15-38

   4. Advanced Microscopy Techniques

      • Valerica Raicu, William F. Schmidt

      Pages 39-75

3. Receptors

   1. Front Matter

      Pages 77-77

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   2. Class A GPCR: Light Sensing G Protein-Coupled Receptor – Focus on Rhodopsin Dimer

      • Beata Jastrzebska

      Pages 79-97

   3. Extreme Vetting of Dopamine Receptor Oligomerization

      • Wesley B. Asher, Signe Mathiasen, Michael D. Holsey, Steven G. Grinnell, Nevin A. Lambert, Jonathan A. Javitch

      Pages 99-127

   4. Class A GPCR: Serotonin Receptors

      • Ellinor Grinde, Katharine Herrick-Davis

      Pages 129-172

   5. Class A GPCRs: Cannabinoid and Opioid Receptor Heteromers

      • Salvador Sierra, Ivone Gomes, Lakshmi A. Devi

      Pages 173-206

   6. Class A GPCR: Di/Oligomerization of Glycoprotein Hormone Receptors

      • Aylin C. Hanyaloglu, F. Fanelli, K. C. Jonas

      Pages 207-231

   7. Chemokine Receptor Oligomerization to Tweak Chemotactic Responses

      • Henry F. Vischer

      Pages 233-272

   8. Secretin Receptor Dimerization. Prototypic of Class B GPCR Behavior

      • Kaleeckal G. Harikumar, Laurence J. Miller

      Pages 273-287

   9. Class B GPCR: Receptors and RAMPs

      • Joseph J. Gingell, Christopher S. Walker, Debbie L. Hay

      Pages 289-305

   10. Class C GPCR: Obligatory Heterodimerization of GABAB Receptor

       • Qing R. Fan, William Y. Guo, Yong Geng, Marisa G. Evelyn

       Pages 307-325

   11. Class C GPCRs: Metabotropic Glutamate Receptors

       • Veronika Hlaváčková, Laurent Prézeau, Jean-Philippe Pin, Jaroslav Blahos

       Pages 327-356

4. Assembly and Trafficking

   1. Front Matter

      Pages 357-357

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   2. The Monomer/Homodimer Equilibrium of G Protein-Coupled Receptors: Formation in the Secretory Pathway and Potential Functional Significance

      • Arthur Gibert, Martin Lehmann, Burkhard Wiesner, Ralf Schülein

      Pages 359-384

   3. Probing Self-Assembly of G Protein-Coupled Receptor Oligomers in Membranes Using Molecular Dynamics Modeling and Experimental Approaches

      • Thomas P. Sakmar, Xavier Periole, Thomas Huber

      Pages 385-414

   4. Interaction of Membrane Cholesterol with GPCRs: Implications in Receptor Oligomerization

      • Durba Sengupta, G. Aditya Kumar, Amitabha Chattopadhyay

      Pages 415-429

G-protein-coupled receptors (GPCRs) are believed to be the largest family of membrane proteins involved in signal transduction and cellular responses. They dimerize (form a pair of macromolecules) with a wide variety of other receptors. The proposed book will provide a comprehensive overview of GPCR dimers, starting with a historical perspective and including, basic information about the different dimers, how they synthesize, their signaling properties, and the many diverse physiological processes in which they are involved.  In addition to presenting information about healthy GPCR dimer activity, the book will also include a section on their pathology and therapeutic potentials.

• Dimers
• GPRC
• Signaling
• Synthesis
• Therapeutic Potential

• Department of Neuroscience and Experimental Therapeutics, Albany Medical College, Albany, USA

  Katharine Herrick-Davis

• Centre for Translational Pharmacology, Institute of Molecular Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom

  Graeme Milligan

• Department of Physiology and Biochemistry, University of Malta, Msida, Malta

  Giuseppe Di Giovanni

Katharine Herrick-Davis is Professor of Neuroscience and Experimental Therapeutics at Albany Medical College, Albany, USA. Her research has focused on investigating receptor dimerization and how it affects receptor function using the 5-HT2C receptor as a model system. 

Graeme Milligan is Professor of Molecular Pharmacology, University of Glasgow, U.K. he is the Dean of Research, College of Medical, Veterinary and Life Sciences, University of Glasgow. His main research group centres on the function, structure and regulation of GPCRs and their interacting proteins. 


Giuseppe Di Giovanni is Professor of Human Physiology, University of Malta, Malta. He is the President of the Malta Neuroscience Network and Treasurer of the Mediterranean Neuroscience Society. His research has focused on the pathophysiology of the monoaminergic systems in different neuropsychiatric disorders, such as Parkinson's disease, depression, drug of abuse and epilepsy.

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