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Neurodegenerative Diseases

Pathology, Mechanisms, and Potential Therapeutic Targets

  • Book
  • © 2017

Overview

Editors:
  1. Philip Beart

    1. University of Melbourne Florey Institute of Neuroscience and Mental Health, Parkville, Australia

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  2. Michael Robinson

    1. Pediatrics and Pharmacology Children’s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, USA

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  3. Marcus Rattray

    1. School of Life Sciences Bradford School of Pharmacy, University of Bradford, Bradford, United Kingdom

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  4. Nicholas J. Maragakis

    1. Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, USA

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  • Discusses molecular and cellular aspects of neurodegeneration in a contemporary context
  • Includes both basic research and clinical perspectives
  • Evaluates modern research methods and contributions

Part of the book series: Advances in Neurobiology (NEUROBIOL, volume 15)

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Table of contents (21 chapters)

  1. Front Matter

    Pages i-xiv
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  2. Major Neurodegenerative Conditions

    1. Front Matter

      Pages 1-1
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    2. Alzheimer’s Disease: Insights from Genetic Mouse Models and Current Advances in Human IPSC-Derived Neurons

      • Anne E. Harasta, Lars M. Ittner
      Pages 3-29

    3. Clinical Aspects of Alzheimer’s Disease

      • Fiona Kumfor, Glenda M. Halliday, Olivier Piguet
      Pages 31-53

    4. Parkinson’s Disease: Basic Pathomechanisms and a Clinical Overview

      • Alastair Noyce, Rina Bandopadhyay
      Pages 55-92

    5. Huntington’s Disease: Pathogenic Mechanisms and Therapeutic Targets

      • Dean J. Wright, Thibault Renoir, Laura J. Gray, Anthony J. Hannan
      Pages 93-128

    6. The Complexity of Clinical Huntington’s Disease: Developments in Molecular Genetics, Neuropathology and Neuroimaging Biomarkers

      • Lynette J. Tippett, Henry J. Waldvogel, Russell G. Snell, Jean-Paul Vonsattel, Anne B. Young, Richard L. M. Faull
      Pages 129-161

    7. Motoneuron Disease: Basic Science

      • Hristelina Ilieva, Nicholas J. Maragakis
      Pages 163-190

    8. Motoneuron Disease: Clinical

      • Hristelina Ilieva, Nicholas J. Maragakis
      Pages 191-210

    9. Multiple Sclerosis: Basic and Clinical

      • Katherine Buzzard, Wing Hei Chan, Trevor Kilpatrick, Simon Murray
      Pages 211-252

  3. Other Neurological Conditions

    1. Front Matter

      Pages 253-253
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    2. Schizophrenia: Basic and Clinical

      • Joseph T. Coyle
      Pages 255-280

    3. Stroke: Basic and Clinical

      • Tarvinder P. Singh, Jonathan R. Weinstein, Sean P. Murphy
      Pages 281-293

    4. Epileptic Encephalopathies as Neurodegenerative Disorders

      • Ingo Helbig, Markus von Deimling, Eric D. Marsh
      Pages 295-315

    5. Neurodegeneration and Pathology in Epilepsy: Clinical and Basic Perspectives

      • Jordan S. Farrell, Marshal D. Wolff, G. Campbell Teskey
      Pages 317-334

    6. Prion Diseases

      • Benjamin C. Whitechurch, Jeremy M. Welton, Steven J. Collins, Victoria A. Lawson
      Pages 335-364

    7. Leukodystrophy: Basic and Clinical

      • Gerald V. Raymond
      Pages 365-382

    8. Traumatic Brain Injury as a Trigger of Neurodegeneration

      • Victoria E. Johnson, William Stewart, John D. Arena, Douglas H. Smith
      Pages 383-400

  4. Key Background and Key Technologies

    1. Front Matter

      Pages 401-401
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    2. Cell Death Mechanisms of Neurodegeneration

      • Jing Fan, Ted M. Dawson, Valina L. Dawson
      Pages 403-425
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Keywords

About this book

Provides a timely overview of critical advances in molecular and cellular neurobiology, covers key methodologies driving progress, and highlights key future directions for research on neuronal injury and neurodegeneration relevant to neuronal brain pathologies. The editors bring together contributions from internationally recognized workers in the field to provide an up to date account of how and why molecular and cellular neurobiology is such an important area for clinical neuroscience. Understanding the molecular aspects of a number of neurodegenerative conditions such as Parkinson's or Alzheimer's disease for the purpose of improving patient management remains a major challenge of neurobiology be it from the basic or clinical perspective. A strategic evaluation of research contributions and the power of modern methods will help advance knowledge over the next years.

Editors and Affiliations

  • University of Melbourne Florey Institute of Neuroscience and Mental Health, Parkville, Australia

    Philip Beart

  • Pediatrics and Pharmacology Children’s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, USA

    Michael Robinson

  • School of Life Sciences Bradford School of Pharmacy, University of Bradford, Bradford, United Kingdom

    Marcus Rattray

  • Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, USA

    Nicholas J. Maragakis

Bibliographic Information

  • Book Title: Neurodegenerative Diseases

  • Book Subtitle: Pathology, Mechanisms, and Potential Therapeutic Targets

  • Editors: Philip Beart, Michael Robinson, Marcus Rattray, Nicholas J. Maragakis

  • Series Title: Advances in Neurobiology

  • DOI: https://doi.org/10.1007/978-3-319-57193-5

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer International Publishing AG 2017

  • Hardcover ISBN: 978-3-319-57191-1Published: 17 July 2017

  • Softcover ISBN: 978-3-319-86099-2Published: 12 June 2018

  • eBook ISBN: 978-3-319-57193-5Published: 03 July 2017

  • Series ISSN: 2190-5215

  • Series E-ISSN: 2190-5223

  • Edition Number: 1

  • Number of Pages: XIV, 542

  • Number of Illustrations: 12 b/w illustrations, 26 illustrations in colour

  • Topics: Neurosciences

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