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  • © 2017

Stroke Genetics

  • Discusses important and novel results from large datasets, as genetics has continued to advance at an unprecedented rate since the first edition
  • Includes new chapters on nonCaucasian stroke, advanced imaging and cerebral venous thrombosis-
  • Written by international experts who have been intimately involved in unraveling the genetic etiology of stroke
  • Includes supplementary material: sn.pub/extras

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Table of contents (18 chapters)

  1. Front Matter

    Pages i-xii
  2. Introduction

    • Pankaj Sharma, James F. Meschia
    Pages 1-7
  3. Familial Occurrence and Heritability of Stroke

    • Hugo J. Aparicio, Sudha Seshadri
    Pages 9-20
  4. Genetic Association Studies and Next Generation Sequencing in Stroke: Methods

    • Jane M. Maguire, Elizabeth G. Holliday, Christopher J. Oldmeadow, John Attia, Matthew P. A. Henderson, Guillaume Pare
    Pages 21-52
  5. The Genetics of Cerebral Aneurysms and Other Vascular Malformations

    • Deena M. Nasr, Jennifer Fugate, Robert D. Brown Jr.
    Pages 53-78
  6. Intracerebral Hemorrhage and Cerebral Amyloid Angiopathy

    • Alessandro Biffi, Jonathan Rosand
    Pages 79-92
  7. Monogenic Disorder: Fabry Disease

    • Lionel Ginsberg
    Pages 105-116
  8. Stroke-Like Episodes in Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke-Like Episodes (MELAS)

    • Virginia W. Lin, Douglas M. Sproule, Michio Hirano, Steven G. Pavlakis
    Pages 117-134
  9. Sickle Cell Disease

    • Hyacinth I. Hyacinth, Robert J. Adams
    Pages 135-161
  10. Other Monogenetic Stroke Disorders

    • John W. Cole, Christopher A. Stack
    Pages 163-189
  11. White Matter Disease

    • Anne-Katrin Giese, Natalia S. Rost
    Pages 191-218
  12. Genetics of Carotid Disease

    • Bradford B. Worrall, Nicole A. Chiota-McCollum, Andrew M. Southerland
    Pages 219-245
  13. Genetics of Cervical Artery Dissection

    • Stéphanie Debette
    Pages 247-262
  14. Genetics of Small Vessel Disease

    • Rainer Malik
    Pages 263-279
  15. Non-Caucasian Stroke Genetics

    • Stacie L. Demel, Daniel Woo
    Pages 281-293
  16. Cerebral Venous Thrombosis: Genetic Aspects

    • José M. Ferro, Diana Aguiar de Sousa, Sofia Oliveira
    Pages 295-326
  17. Stroke Pharmacogenetics

    • Lauren E. Walker, Anna Stewart, Sir Munir Pirmohamed
    Pages 327-410
  18. Genetic Research and the Law

    • Browne C. Lewis
    Pages 411-423
  19. Back Matter

    Pages 425-431

About this book

This revised, expanded second edition updates the reader on this fast moving field as well providing an overall understanding of the genetics of complex diseases by using stroke as a paradigm. The reader will gain a comprehensive understanding of cerebrovascular genetics including the epidemiological evidence for the genetic basis of ischemic and hemorrhagic stroke, knowledge of its molecular basis from association, linkage and recent genomewide studies, and also monogenic disorders. Finally, the legal and ethical complexities in dealing with these issues are discussed.

Stroke Genetics is a valuable resource for neurologists, stroke physicians, hypertension specialists, internists, clinical pharmacologists and those in training, as well as researchers in the field of disease genetics.

Editors and Affiliations

  • Department of Neurology, Institute of Cardiovascular Research Royal Holloway College, University of London Imperial College London Healthcare NHS Trust, London, United Kingdom

    Pankaj Sharma

  • Department of Neurology, Mayo Clinic, Jacksonville, USA

    James F. Meschia

About the editors

Pankaj Sharma, MD, PhD, FRCP

Reader & Consultant Neurologist

Imperial College London & Hammersmith Hospitals

London, UK

James F. Meschia, MD

Chair, Department of Neurology

Mayo Clinic

Jacksonville, Florida, USA

Bibliographic Information

  • Book Title: Stroke Genetics

  • Editors: Pankaj Sharma, James F. Meschia

  • DOI: https://doi.org/10.1007/978-3-319-56210-0

  • Publisher: Springer Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2017

  • Hardcover ISBN: 978-3-319-56208-7Published: 26 June 2017

  • Softcover ISBN: 978-3-319-85854-8Published: 12 August 2018

  • eBook ISBN: 978-3-319-56210-0Published: 12 June 2017

  • Edition Number: 2

  • Number of Pages: XII, 431

  • Number of Illustrations: 13 b/w illustrations, 26 illustrations in colour

  • Topics: Neurology, Internal Medicine, Human Genetics

Buy it now

Buying options

eBook USD 149.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 199.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access