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Neuroepigenomics in Aging and Disease

  • One of the first books covering the major epigenetic changes on brain disorders throughout the entire lifespan of the patients
  • An invaluable reference that supplies extensive coverage of the role of all the principal epigenetic modifications in brain disorders.
  • First volume to include specific scientific knowledge on neuroepigenomics, including informative summaries that will help everyone from researchers to non-scientists to understand the complexity of the human brain

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 978)

Part of the book sub series: Proteomics, Metabolomics, Interactomics and Systems Biology (PMISB)

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Table of contents (25 chapters)

  1. Front Matter

    Pages i-xiii
  2. Neurodevelopmental and Childhood Disorders

    1. Front Matter

      Pages 1-1
    2. Epigenetics of Autism Spectrum Disorder

      • Michelle T. Siu, Rosanna Weksberg
      Pages 63-90
  3. Adolescence Brain Diseases

    1. Front Matter

      Pages 91-91
    2. Eating Disorders and Epigenetics

      • Lea Thaler, Howard Steiger
      Pages 93-103
    3. Drug Addiction and DNA Modifications

      • Amber N. Brown, Jian Feng
      Pages 105-125
    4. Drug Addiction and Histone Code Alterations

      • Hee-Dae Kim, Tanessa Call, Samantha Magazu, Deveroux Ferguson
      Pages 127-143
    5. Anxiety and Epigenetics

      • Andrew A. Bartlett, Rumani Singh, Richard G. Hunter
      Pages 145-166
  4. Brain Disorders During Adulthood

    1. Front Matter

      Pages 167-167
    2. DNA Methylation in Major Depressive Disorder

      • Ehsan Pishva, Bart P. F. Rutten, Daniel van den Hove
      Pages 185-196
    3. Noncoding RNAs in Depression

      • Rixing Lin, Gustavo Turecki
      Pages 197-210
    4. DNA Methylation in Schizophrenia

      • Lotta-Katrin Pries, Sinan Gülöksüz, Gunter Kenis
      Pages 211-236
    5. Epigenetic Mechanisms of Gene Regulation in Amyotrophic Lateral Sclerosis

      • Alba Jimenez-Pacheco, Jaime M. Franco, Soledad Lopez, Juan Miguel Gomez-Zumaquero, Maria Magdalena Leal-Lasarte, Diana E. Caballero-Hernandez et al.
      Pages 255-275
    6. Epigenetics of Huntington’s Disease

      • Silvia Bassi, Takshashila Tripathi, Alan Monziani, Francesca Di Leva, Marta Biagioli
      Pages 277-299
  5. Elderly Disorders

    1. Front Matter

      Pages 301-301

About this book

Epigenetic mechanisms (DNA modifications, histone alterations and non-coding RNAs) are crucial for transcriptional regulation and alterations of the “physiological epigenome” are increasingly associated with human diseases. During the last decade the emerging field of neuroepigenomics have started to impact tremendously in areas such learning and memory, addiction or neurodegeneration. This expert volume covers the role of epigenetic molecular mechanism in regulation of central nervous system’s function, one of the most exciting areas of contemporary molecular neuroscience. The book describes the current knowledge on the epigenetic basis of human disease covering the complete lifespan: from neurodevelopment/childhood (Rett Syndrome, Rubinstein-Taybi, autism), adolescence (eating disorders, drug addiction, anxiety), adulthood (depression, schizophrenia, amyotrophic lateral sclerosis, Huntington’s disease) and elderly (Alzheimer’s disease, Parkinson’s disease).

The book also covers the three major players on neuroepigenomic mechanisms: histones alterations, DNA modifications and non-coding RNAs, their roles at the molecular and cellular level and the impact of their alterations on neuronal function and behavior. Finally, a special chapter on state-of-the-art technologies helps the reader not only to understand epigenetic driven changes in human cognition and diseases but also the methodology that will help to generate paradigm shifts on our understanding of brain function and the role of the neuroepigenome in human diseases.

Editors and Affiliations

  • Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), CATALONIA, Spain

    Raul Delgado-Morales

About the editor

Raúl Delgado-Morales holds a PhD in Neuroscience. He completed his doctoral studies at the Universitat Autònoma de Barcelona working on the field of epigenetics on depression. He continued his research as a postdoc at the Max Planck Institute of Psychiatry in Munich. Dr. Delgado-Morales currently works as a postdoctoral researcher at the Bellvitge Biomedical Research Institute (IDIBELL), in Barcelona, Spain in the field of neuroepigenomics.

Bibliographic Information

  • Book Title: Neuroepigenomics in Aging and Disease

  • Editors: Raul Delgado-Morales

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-3-319-53889-1

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer International Publishing AG 2017

  • Hardcover ISBN: 978-3-319-53888-4Published: 31 May 2017

  • Softcover ISBN: 978-3-319-85266-9Published: 02 August 2018

  • eBook ISBN: 978-3-319-53889-1Published: 18 May 2017

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XIII, 525

  • Number of Illustrations: 2 b/w illustrations, 39 illustrations in colour

  • Topics: Proteomics, Gene Expression, Gene Function

Buy it now

Buying options

eBook USD 149.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 199.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 279.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access