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Leucine-Rich Repeat Kinase 2 (LRRK2)

  • Book
  • © 2017

Overview

Editors:
  1. Hardy J. Rideout

    1. Biomedical Research Foundation of the Academy of Athens (BRFAA), Athens, Greece

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  • Thorough overview of the current state of knowledge on LRRK2
  • Discussed the links between LRRK2 mutations and Parkinson's Disease
  • Explores what we know about the normal function of LRRK2
  • Includes supplementary material: sn.pub/extras

Part of the book series: Advances in Neurobiology (NEUROBIOL, volume 14)

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Table of contents (13 chapters)

  1. Front Matter

    Pages i-xvii
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  2. Clinical and Genetic Considerations of LRRK2 Associated Parkinson’s Disease

    1. Front Matter

      Pages 1-1
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    2. Leucine-Rich Repeat Kinase (LRRK2) Genetics and Parkinson’s Disease

      • Edoardo Monfrini, Alessio Di Fonzo
      Pages 3-30

    3. Clinical Features of LRRK2 Carriers with Parkinson’s Disease

      • Meir Kestenbaum, Roy N. Alcalay
      Pages 31-48

  3. Fundamentals of LRRK2 Biology

    1. Front Matter

      Pages 49-49
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    2. LRRK2 Phosphorylation

      • R. Jeremy Nichols
      Pages 51-70

    3. Understanding the GTPase Activity of LRRK2: Regulation, Function, and Neurotoxicity

      • An Phu Tran Nguyen, Darren J. Moore
      Pages 71-88

    4. LRRK2 and Autophagy

      • Claudia Manzoni, Patrick A. Lewis
      Pages 89-105

    5. Molecular Insights and Functional Implication of LRRK2 Dimerization

      • Laura Civiero, Isabella Russo, Luigi Bubacco, Elisa Greggio
      Pages 107-121

    6. LRRK2 and the Immune System

      • Nicolas L. Dzamko
      Pages 123-143

    7. Regulation of LRRK2 by Phosphatases

      • Jean-Marc Taymans
      Pages 145-160

  4. LRRK2 Neurodegeneration, Modeling, and Therapeutic Options

    1. Front Matter

      Pages 161-161
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    2. Models of LRRK2-Associated Parkinson’s Disease

      • Yulan Xiong, Ted M. Dawson, Valina L. Dawson
      Pages 163-191

    3. LRRK2 and the “LRRKtosome” at the Crossroads of Programmed Cell Death: Clues from RIP Kinase Relatives

      • Hardy J. Rideout, Diane B. Re
      Pages 193-208

    4. Interaction of LRRK2 and α-Synuclein in Parkinson’s Disease

      • João Paulo Lima Daher
      Pages 209-226

    5. Mechanisms of Mutant LRRK2 Neurodegeneration

      • Mark R. Cookson
      Pages 227-239

    6. Small-Molecule Inhibitors of LRRK2

      • John M. Hatcher, Hwan Geun Choi, Dario R. Alessi, Nathanael S. Gray
      Pages 241-264

  5. Back Matter

    Pages 265-271
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Keywords

About this book

This is the first book to assemble the leading researchers in the field of LRRK2 biology and neurology and provide a snapshot of the current state of knowledge, encompassing all major aspects of its function and dysfunction. The contributors are experts in cell biology and physiology, neurobiology, and medicinal chemistry, bringing a multidisciplinary perspective on the gene and its role in disease. The book covers the identification of LRRK2 as a major contributor to the pathogenesis of Parkinson's Disease. It also discusses the current state of the field after a decade of research, putative normal physiological roles of LRRK2, and the various pathways that have been identified in the search for the mechanism(s) of its induction of neurodegeneration.

Editors and Affiliations

  • Biomedical Research Foundation of the Academy of Athens (BRFAA), Athens, Greece

    Hardy J. Rideout

Bibliographic Information

  • Book Title: Leucine-Rich Repeat Kinase 2 (LRRK2)

  • Editors: Hardy J. Rideout

  • Series Title: Advances in Neurobiology

  • DOI: https://doi.org/10.1007/978-3-319-49969-7

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer International Publishing AG 2017

  • Hardcover ISBN: 978-3-319-49967-3Published: 04 April 2017

  • Softcover ISBN: 978-3-319-84287-5Published: 07 August 2018

  • eBook ISBN: 978-3-319-49969-7Published: 28 March 2017

  • Series ISSN: 2190-5215

  • Series E-ISSN: 2190-5223

  • Edition Number: 1

  • Number of Pages: XVII, 271

  • Number of Illustrations: 10 b/w illustrations, 17 illustrations in colour

  • Topics: Neurosciences, Neurology

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