Design of Polymeric Platforms for Selective Biorecognition

1. Front Matter

   Pages i-viii

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2. Selective Biorecognition on Polymer Surfaces: General Issues

   • Juan Rodríguez-Hernández, Aitziber L. Cortajarena

   Pages 1-9

3. Patterning and Functionalization of Polymeric Surfaces

   • Juan Rodríguez-Hernández

   Pages 11-43

4. Biorecognition Molecules: Types and Molecular Basis and Development of Specificity

   • Robert E. Collins, Aitziber L. Cortajarena

   Pages 45-63

5. Modification of Polymer Surfaces for Biofunctionalization

   • Guillaume Delaittre

   Pages 65-92

6. Polymer Gradient Surfaces for Biomedical Applications

   • Paul M. Reynolds, Nikolaj Gadegaard

   Pages 93-122

7. Polymer Replication Techniques

   • John M. Stormonth-Darling, Rasmus H. Pedersen, Nikolaj Gadegaard

   Pages 123-155

8. Lithographic Processes for the Design of Biosurfaces

   • Nicolas Delorme

   Pages 157-195

9. Inkjet Printing of Biomolecules for Biorecognition

   • Terence G. Henares, Kentaro Yamada, Koji Suzuki, Daniel Citterio

   Pages 197-235

10. Honeycomb Structured Films Prepared by Breath Figures: Fabrication and Application for Biorecognition Purposes

    • Alexandra Muñoz-Bonilla, Juan Rodríguez-Hernández

    Pages 237-271

11. Polymer Brushes with Precise Architectures for Molecular Biorecognition

    • Mónica Pérez-Perrino, Serena Molina, Rodrigo Navarro

    Pages 273-303

12. Microfluidic Systems with Functional Patterned Surface for Biomedical Applications

    • Kin Fong Lei, I-Chi Lee, Tim C. Lei

    Pages 305-324

13. Biopatterns Created Using Colloidal Templates

    • Qin Li, Maria Askildsen, Ehsan Eftekhari

    Pages 325-346

14. Electrochemical Approaches for Molecular Surface Imprinting of Polymers Toward Fully Synthetic Receptors for Selective Recognition of Proteins

    • Frieder W. Scheller, Aysu Yarmana, Róbert E. Gyurcsányic

    Pages 347-356

15. Bio-nanostructured Interfaces Fabricated by Scanning Probe Nanolithography (SPN)

    • Juan Rodríguez-Hernández

    Pages 357-385

16. Selective Biorecognition on Polymer Surfaces: Remarks and Future Trends

    • Juan Rodríguez-Hernández, Aitziber L. Cortajarena

    Pages 387-389

This book addresses in an integrated manner all the critical aspects for building the next generation of biorecognition platforms - from biomolecular recognition to surface fabrication. The most recent strategies reported to create surface nano and micropatterns are thoroughly analyzed. This book contains descriptions of the types of molecules immobilized at surfaces that can be used for specific biorecognition, how to immobilize them, and how to control their arrangement and functionality at the surface. Small molecules, peptides, proteins and oligonucleotides are at the core of the biorecognition processes and will constitute a special part of this book. The authors include detailed information on biological processes, biomolecular screening, biosensing, diagnostic and detection devices, tissue engineering, development of biocompatible materials and biomedical devices.

• Biointerfaces
• Biomolecular Specificity
• Biorecognition Moieties
• Biorecognition Platforms
• Biotechnology
• Cell Immobilization
• Functional Surfaces
• Polymer Surfaces
• Selective Immobilization
• Surface Chemistry
• Surface Patterning

• Institute of Polymer Science &Technology, Madrid, Spain

  Juan Rodríguez-Hernández

• IMDEA Nanociencia and CNB-CSIC-IMDEA Nanociencia Associated Unit “Unidad Nanobiotecnología”, Madrid, Spain

  Aitziber L. Cortajarena

Dr. Juan Rodríguez-Hernández is tenured scientist at the Instituto de Ciencia y Tecnologia de Polimeros (Madrid-Spain) since 2008. He obtained his PhD from the Max-Planck Institute for Polymer Research in Mainz, Germany in 2003. He then joined the Laboratoire de Chimie des Polymères Organiques in Bordeaux France as post-doc and later as research fellow until 2008. His research interests include micro/nanostructuration of polymeric surfaces, the preparation of smart surfaces and the control of the interaction of surfaces with microorganisms.

Dr. Aitziber L. Cortajarena earned her Ph.D. in Biochemistry from the Universidad del País Vasco in 2002. Then, she joined the group of Prof. L. Regan at Yale University, USA, as a Postdoctoral Fellow. She worked on protein design, structure, and function. She joined IMDEA Nanociencia as Group Leader in 2010 and started her independent research lines. Her research focuses on protein engineering for biotechnological applications and the generation of biofunctional nanostructures, surfaces, and bioinspired materials for applications in nano-biotechnology and nanomedicine.

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