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Targeting the Broadly Pathogenic Kynurenine Pathway

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  • © 2015

Overview

Editors:
  1. Sandeep Mittal

    1. Chairman, Department of Neurosurgery, Wayne State University, Detroit, USA

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  • Combines basic understanding of the role of the kynurenine pathway with translational applications and clinical relevance
  • Explains the role of the kynurenine pathway in various disease states
  • Explores ongoing clinical trials using IDO/TDO inhibitors

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Table of contents (31 chapters)

  1. Front Matter

    Pages i-xv
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  2. Overview

    1. Front Matter

      Pages 1-1
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    2. Overview of the Kynurenine Pathway of Tryptophan Metabolism

      • Sharon K. Michelhaugh, Anthony R. Guastella, Sandeep Mittal
      Pages 3-9

    3. Tryptophan Metabolism and the Hepatic Kynurenine Pathway in Health and Disease

      • Abdulla A.-B. Badawy
      Pages 11-30

    4. Nutritional Aspects of Tryptophan Metabolism

      • Katsumi Shibata
      Pages 31-43

    5. Kynurenines and Brain Development

      • Trevor W. Stone, Caroline M. Forrest, L. Gail Darlington
      Pages 45-61

    6. Role of Kynurenine Pathway in Aging

      • Daniela Ramirez Ortega, Dinora González Esquivel, Benjamín Pineda, Camilo Ríos, Verónica Pérez de la Cruz
      Pages 63-74

    7. Role of Tryptophan Metabolism in Mood, Behavior, and Cognition

      • Johanna M. Gostner, Kathrin Becker, Barbara Sperner-Unterweger, Florian Überall, Dietmar Fuchs, Barbara Strasser
      Pages 75-89

  3. Systemic Diseases

    1. Front Matter

      Pages 91-91
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    2. Role of the Kynurenine Pathway in Immune-Mediated Inflammation

      • Adam P. Cribbs, Richard O. Williams
      Pages 93-107

    3. Role of Kynurenine Pathway in Allergy

      • Hirokazu Kawasaki, Shau-Ku Huang
      Pages 109-119

    4. Role of Kynurenine Pathway in HIV/AIDS

      • Jean-Pierre Routy, Vikram Mehraj, Kishanda Vyboh
      Pages 121-131

    5. Role of Kynurenine Pathway in Cardiovascular Diseases

      • Harald Mangge, Eva Reininghaus, Dietmar Fuchs
      Pages 133-143

    6. Role of Kynurenine Pathway in the Respiratory System

      • René Lutter
      Pages 145-155

    7. Role of Kynurenine Pathway in Gastrointestinal Diseases

      • David M. Alvarado, Srikanth Santhanam, Matthew A. Ciorba
      Pages 157-167

    8. Role of Kynurenine Pathway in Insulin Resistance: Toward Kynurenine Hypothesis of Insulin Resistance and Diabetes

      • Gregory F. Oxenkrug
      Pages 169-178

    9. Role of Kynurenine Pathway in Infections

      • Silvia Kathrin Eller, Walter Däubener
      Pages 179-190

  4. CNS Disorders

    1. Front Matter

      Pages 191-191
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    2. The Role of the Kynurenine Pathway in Neurodegenerative Diseases

      • Zsófia Majláth, József Toldi, László Vécsei
      Pages 193-204

    3. Role of the Kynurenine Pathway in Epilepsy

      • Monika Sharma, Chaitali Anand, Diane C. Chugani
      Pages 205-213
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Keywords

About this book

Tryptophan metabolism via kynurenine pathway plays a critical role in both health and a variety of human diseases. This book highlights the known associations between kynurenine pathway and various disease states, as well as examines the current status of drug development and clinical trials of compounds known to alter tryptophan metabolism. The research plays a critical role in molecular targeted therapies directed at altering the kynurenine pathway of tryptophan metabolism. The initial and rate-limiting step of tryptophan metabolism is mediated by one of two enzymes, tryptophan-2,3-dioxygenase (TDO; predominantly in the liver, but also in the brain) and indoleamine-2,3-dioxygenase (IDO; in a host of tissues in response to immune activation). Targeting the enzymes IDO and TDO, as well as other downstream effectors would therefore be likely to generate novel treatment options that would be helpful in a wide variety of clinical settings. This book provides a unique bridge between basic mechanistic understanding of the role of the kynurenine pathway with translational applications and clinical relevance. It will explore the indications that tryptophan metabolism is a potential biomarker of disease activity, can contribute to local and possibly systemic immune suppression in cancer, and is an attractive target for which a variety of inhibitors are readily available.

Editors and Affiliations

  • Chairman, Department of Neurosurgery, Wayne State University, Detroit, USA

    Sandeep Mittal

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