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NMR-Bioassay Guided Isolation of the Natural 20S Proteasome Inhibitors from Photorhabdus Luminescens

A Novel NMR-Tool for Natural Product Detection

  • Book
  • © 2014

Overview

Authors:
  1. Martin Lorenz Stein

    1. Faculty of Chemistry, Department of Biochemistry, Technical University of Munich, Garching, Germany

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  • Nominated as an Outstanding Ph.D. thesis by TU München, Germany
  • Highlights a new approach to access undisclosed natural products
  • Describes biological dimensions of proteasome inhibitors
  • Includes supplementary material: sn.pub/extras

Part of the book series: Springer Theses (Springer Theses)

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Table of contents (5 chapters)

  1. Front Matter

    Pages i-xvi
    Download chapter PDF

  2. Introduction

    • Martin Lorenz Stein
    Pages 1-22

  3. Objective

    • Martin Lorenz Stein
    Pages 23-24

  4. Materials and Methods

    • Martin Lorenz Stein
    Pages 25-40

  5. Results

    • Martin Lorenz Stein
    Pages 41-65

  6. Discussion

    • Martin Lorenz Stein
    Pages 67-71
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Keywords

About this book

Martin Stein's thesis describes a novel methodology for natural product discovery. Due to its high degree of reproducibility, robustness and sensitivity, the technique can be utilized to detect even trace amounts of bioactive substances in heterogeneous matrices such as fermentation broths or crude organic extracts. This research is thus relevant for a large number of researchers working in natural product discovery. Applications of this novel NMR-based approach include suitable environmental triggers for the induction of biosynthetic machineries. The author demonstrates the extraordinary value of this approach by the successful isolation of two potent inhibitors of the pharmaceutically relevant proteasome core particle from the insect pathogen photorhabdus luminescens. This thesis has led to a number of publications in high-impact journals.

Authors and Affiliations

  • Faculty of Chemistry, Department of Biochemistry, Technical University of Munich, Garching, Germany

    Martin Lorenz Stein

Bibliographic Information

  • Book Title: NMR-Bioassay Guided Isolation of the Natural 20S Proteasome Inhibitors from Photorhabdus Luminescens

  • Book Subtitle: A Novel NMR-Tool for Natural Product Detection

  • Authors: Martin Lorenz Stein

  • Series Title: Springer Theses

  • DOI: https://doi.org/10.1007/978-3-319-07914-1

  • Publisher: Springer Cham

  • eBook Packages: Chemistry and Materials Science, Chemistry and Material Science (R0)

  • Copyright Information: Springer International Publishing Switzerland 2014

  • Hardcover ISBN: 978-3-319-07913-4Published: 17 July 2014

  • Softcover ISBN: 978-3-319-38399-6Published: 01 October 2016

  • eBook ISBN: 978-3-319-07914-1Published: 23 June 2014

  • Series ISSN: 2190-5053

  • Series E-ISSN: 2190-5061

  • Edition Number: 1

  • Number of Pages: XVI, 71

  • Number of Illustrations: 4 b/w illustrations, 24 illustrations in colour

  • Topics: Spectroscopy/Spectrometry, Biochemistry, general, Bioorganic Chemistry

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