Calcium Signaling In Airway Smooth Muscle Cells

1. Front Matter

   Pages i-xiv

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2. Ryanodine and Inositol Trisphosphate Receptors/Ca2+ Release Channels in Airway Smooth Muscle Cells

   • Lin Mei, Yun-Min Zheng, Yong-Xiao Wang

   Pages 1-20

3. Kv7 (KCNQ) Potassium Channels and L-type Calcium Channels in the Regulation of Airway Diameter

   • Kenneth L. Byron, Lioubov I. Brueggemann, Priyanka P. Kakad, Jennifer M. Haick

   Pages 21-33

4. Transient Receptor Potential and Orai Channels in Airway Smooth Muscle Cells

   • Jun-Hua Xiao, Yong-Xiao Wang, Yun-Min Zheng

   Pages 35-48

5. Large-Conductance Calcium-Activated Potassium Channels

   • Hiroaki Kume

   Pages 49-83

6. Calcium-Activated Chloride Channels

   • George Gallos, Charles W. Emala Sr.

   Pages 85-106

7. Local Calcium Signaling in Airway Smooth Muscle Cells

   • Qing-Hua Liu, Carlo Savoia, Yong-Xiao Wang, Yun-Min Zheng

   Pages 107-124

8. Regulation of Airway Smooth Muscle Contraction by Ca2+ Signaling: Physiology Revealed by Microscopy Studies of Lung Slices

   • Michael J. Sanderson

   Pages 125-145

9. Temporal Aspects of Ca2+ Signaling in Airway Myocytes

   • Etienne Roux

   Pages 147-175

10. Mechanisms Underlying Ca2+ Store Refilling in Airway Smooth Muscle

    • Charlotte K. Billington, Ian P. Hall, Carl P. Nelson

    Pages 177-193

11. Novel Mechanisms in Ca2+ Homeostasis and Internal Store Refilling of Airway Smooth Muscle

    • Luke J. Janssen

    Pages 195-209

12. The Role of Mitochondria in Calcium Regulation in Airway Smooth Muscle

    • Philippe Delmotte, Li Jia, Gary C. Sieck

    Pages 211-234

13. Role of Caveolae in the Airway

    • Christina M. Pabelick, Brij B. Singh, Y. S. Prakash

    Pages 235-246

14. CD38-Cyclic ADP-Ribose-Mediated Calcium Signaling in Airway Myocytes

    • Deepak A. Deshpande, Alonso Guedes, Mythili Dileepan, Timothy F. Walseth, Mathur S. Kannan

    Pages 247-267

15. Pathways and Signaling Crosstalk with Oxidant in Calcium Influx in Airway Smooth Muscle Cells

    • Lei Cai, Qinghua Hu

    Pages 269-284

16. Role of RhoA/Rho-kinase and Calcium Sensitivity in Airway Smooth Muscle Functions

    • Satoru Ito

    Pages 285-307

17. Role of Integrins in the Regulation of Calcium Signaling

    • Thai Tran, Chun Ming Teoh

    Pages 309-320

18. Sex Steroid Signaling in the Airway

    • Y. S. Prakash, Venkatachalem Sathish, Elizabeth A. Townsend

    Pages 321-332

19. Regulation of Contractility in Immature Airway Smooth Muscle

    • Y. S. Prakash, Christina M. Pabelick, Richard J. Martin

    Pages 333-340

20. Mathematical Modeling of Calcium Dynamics in Airway Smooth Muscle Cells

    • James Sneyd, Pengxing Cao, Xiahui Tan, Michael J. Sanderson

    Pages 341-357

This book explores the role calcium signaling plays in cellular responses in almost all types of cells including airway smooth muscle cells. This universal signaling may result from extracellular calcium influx and/or intracellular calcium release, which are precisely controlled and regulated by ion channels, exchangers and/or transporters on the plasmalemmal or sarcoplasmic reticulum membrane. First, several chapters detail calcium release channels (ryanodine receptors and inositol trisphosphate receptors), voltage-dependent potassium channels, transient receptor potential channels, Orai channels, calcium-activated potassium channels, and calcium-activated chloride channels. Well-characterized sodium-calcium exchangers, voltage-dependent calcium channels, and calcium pumps are described also in depth over many chapters.

Ca2+ signaling can be expressed in Ca2+ sparks, waves, oscillations, and global changes in intracellular Ca2+ concentration. Calcium in subcellular compartments (cytosol, sarcoplasmic reticulum, mitochondria, and caveolae) also exhibit dynamic crosstalk. Many molecules including FK506 binding proteins, cyclic adenosine diphosphate ribose, reactive oxygen species, RhoA kinases, caveolin and integrins can modify and induce spatial, temporal and compartmental variations of calcium signaling. In addition, calcium signaling can exhibit sex hormone- and age-dependent changes. A number of chapters are dedicated to covering these diverse formats, spatiotemporal characteristics, multifaceted network and mathematical modeling of Ca2+ signaling.

Neurotransmitters, hormones, growth factors, inflammatory cytokines, and other stimuli may lead to multiple cellular responses by inducing Ca2+ signaling in airway smooth muscle cells. Increasing evidence suggests that Ca2+ pumps and canonical transient receptor potential channels are essential for airway smooth muscle remodeling. Accordingly, several chapters summarize recent advances in the studies of the key role of calcium signaling in physiological cellular responses as well as the development of asthma, chronic obstructive pulmonary disease and other respiratory disorders.

• airway smooth muscle cells
• asthma
• calcium signaling
• calcium sparks

• Albany Medical College Center for Cardiovascular Sciences, Albany, USA

  Yong-Xiao Wang

Dr. Yong-Xiao Wang is a Full Professor in the Center for Cardiovascular Sciences at Albany Medical College, USA. He earned his M.D. at the Wannan Medical College and Ph.D. at the Fourth Military Medical University, and received his postdoctoral training at the Technology University of Munich and University of Pennsylvania. Subsequently, Dr. Wang worked as an Assistant Professor in the Department of Animal Biology at the University of Pennsylvania. Dr. Wang has been a first author, key contributor and corresponding author in numerous publications in such high-impact journals such as Circ Res, Proc Natl Acad Sci U S A, Nature, and Antioxid Redox Signal. He has been a principal investigator on several NIH grants. Dr. Wang has collaborated with numerous well-known scientists, received multiple prestigious awards, served in various NIH study sections and other grant review panels, reviewed manuscripts for many scientific journals, and trained a number of scholars (some of whom are independent investigators in the field).

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