Functional Ultrastructure

1. Front Matter

   Pages I-XV

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2. Structural Organisation of a Mammalian Cell

   Pages 2-3

3. The Nucleus

   1. Architecture of the Cell Nucleus

      Pages 4-5

   2. Cytochemical Detection of Ribonucleoproteins

      Pages 6-6

   3. Nuclear Lamina

      Pages 6-7

   4. Detection of Sites of DNA Replication and of Interphase Chromosome Domains

      Pages 8-9

   5. Nucleolus

      Pages 10-11

   6. Changes of the Nucleolar Architecture

      Pages 12-13

   7. Detection of Sites of RNA Synthesis

      Pages 14-15

   8. Nuclear Pore Complexes

      Pages 16-17

   9. Nuclear Pore Complexes: Structural Changes as Monitored by Time-Lapse Atomic Force Microscopy

      Pages 18-19

   10. Mitosis and Cell Division

       Pages 20-21

   11. Apoptosis

       Pages 22-22

   12. Viral Inclusions

       Pages 22-23

4. The Cytoplasm: The Secretory System

   1. Secretory Pathway of Pancreatic Acinar Cells

      Pages 24-25

   2. Ribosomes, Rough Endoplasmic Reticulum

      Pages 26-27

   3. Nuclear Envelope and Rough Endoplasmic Reticulum

      Pages 28-29

   4. Rough Endoplasmic Reticulum: Site of Protein Translocation and Initiation of Protein N-Glycosylation

      Pages 30-31

   5. Oligosaccharide Trimming, Reglucosylation, and Protein Quality Control in the Rough Endoplasmic Reticulum

      Pages 32-33

   6. Rough Endoplasmic Reticulum: Storage Site of Aggregates of Misfolded Glycoproteins

      Pages 34-35

The period between 1950 and 1980 were the golden It also provides unique insights into how pathological years of transmission electron microscopy and pro- processes affect cell organization. duced a plethora of new information on the structure of This information is vital to current work in which cells that was coupled to and followed by biochemical the emphasis is on integrating approaches from p- and functional studies. TEM was king and each micro- teomics, molecular biology, molecular imaging and graph of a new object produced new information that physiology, and pathology to understand cell functions led to new insights on cell and tissue organization and and derangements in disease. In this current era, there is their functions. The quality of data represented by the a growing tendency to substitute modern light mic- images of cells and tissues had been perfected to a very scopic techniques for electron microscopy because it is high level by the great microscopists of the era including less technically demanding and is more readily available Palade, Porter, Fawcett, Sjostrand, Rhodin and many to researchers. This atlas reminds us that the infor- others. At present, the images that we see in leading tion obtained by electron microscopy is invaluable and journals for the most part do not reach the same techni- has no substitute.

• ATP
• Antigen
• DNA
• Glycogen
• Oligosaccharid
• biosynthesis
• cell
• cell biology
• cytology
• electron microscopy
• histology
• matrix
• molecular biology
• proteins
• tissue

"... I recommend this atlas to all students of biology and pathology but especially those people buying for a university / TAFE library where students or researchers will be using this text." Australian Journal of Medical Science 2/2006, vol. 27, No. 1

• Institut für Histologie und Embryologie, Abteilung für Zellbiologie und Ultrastrukturforschung, Medizinische Universität Wien, Zentrum für Anatomie und Zellbiologie, Vienna, Austria

  Margit Pavelka

• Abteilung für Zell- und Molekularpathologie, Universität Zürich, Zurich, Switzerland

  Jürgen Roth

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