Bioradicals Detected by ESR Spectroscopy

1. Front Matter

   Pages I-VII

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2. Introduction

   1. Overview of bioradicals and ESR technology

      • H. Ohya-Nishiguchi

      Pages 1-15

   2. Chemistry of oxygen radicals

      • I. Yamazaki

      Pages 17-29

   3. MuItiquantum ESR : Physics, technology and applications to bioradicals

      • J. S. Hyde, H. S. Mchaourab, R. A. Strangeway, J. R. Luglio

      Pages 31-47

3. New ESR technologies

   1. Scanning tunneling microscopy (STM) methods for detecting ESR of a single spin center

      • Y. Manassen, E. Ter-Ovanesyan, D. Shachal

      Pages 49-62

   2. An open space ESR spectrometer and its application to high dielectric loss samples

      • J. Sohma, A. Minegishi, R. Amano, H. Hara

      Pages 63-68

4. ESR imaging

   1. New experimental modalities of low frequency electron paramagnetic resonance imaging

      • A. Sotgiu, M. Alecci, J. Brivati, G. Placidi, L. Testa

      Pages 69-92

   2. Whole body electron spin resonance imaging spectrometer

      • M. C. R. Symons

      Pages 93-102

   3. Development of the rapid field scan L-band ESR-CT system

      • T. Ogata

      Pages 103-111

5. Spin Trapping

   1. Spin trapping

      • E. G. Janzen

      Pages 113-142

   2. History of spin trapping in Japan

      • R. Konaka

      Pages 143-154

6. In vivo spin trapping

   1. In vivo ESR observation of bioradical metabolites in living animals

      • H. Fujii, J. Koscielniak, L. J. Berliner

      Pages 155-162

   2. Dithiocarbamate spin traps for in vivo detection of nitric oxide production in mice

      • C.-S. Lai, A. M. Komarov

      Pages 163-171

7. Spin labels

   1. Recent developments in spin labeling

      • D. Marsh

      Pages 173-191

   2. Electron spin resonance imaging of rat brain

      • M. Hiramatsu, M. Komatsu, K. Oikawa, H. Noda, R. Niwa, R. Konaka et al.

      Pages 193-202

8. Metal complexes and metalloproteins

   1. ESEEM spectroscopy — probing active site structures of metalloproteins

      • J. Peisach

      Pages 203-215

   2. Nitric oxide, a versatile biological ligand for hemeproteies

      • T. Yoshimura

      Pages 217-235

9. Antioxidants and foods

   1. Vitamin E and antioxidant interactions in biological systems

      • L. Packer

      Pages 237-258

   2. Antioxidant activity of vitamin E and vitamin C derivatives in membrane mimetic systems

      • Z.-L. Liu

      Pages 259-275

   3. Action of antioxidants as studied by electron spin resonance

      • E. Niki

      Pages 277-283

This book is based on two keywords: Bioradical and ESR. Bioradical is a newly coined word which encompasses paramagnetic species in biological systems, such as active oxygen radicals and transition metal ions. Research on the structure and function of bioradicals has been attrac­ ting growing attention in the field of biological science, and comprehensive investigations from many fields are helping to understand the real features of these species. ESR spectroscopy also has interdisciplinary features in that its techniques have been applied to many fields, ranging from physics to medicine. It was our hope, therefore, that this book would help to clarify many aspects of bioradicals and that significant progress would be achieved in combining basic research from many different fields. This book arises from the First International Conference on Bioradicals Detected by ESR Spectroscopy (ICBES), which was held in Yamagata, a city in the Yamagata Prefecture of Japan, in 1994. About 300 participants from 16 different countries attended this conference, and about 170 papers were presented. This book is a collection of contributions from the conference and also contains eleven chapters selected by the editorial board, based on sugges­ tions from the members of the international editorial board of ICBES. The Yamagata Technopolis Foundation is developing a biomedical technology for the 21st century based on life science fused with material and physical science. Based on such a techno­ logy, the Foundation plans to share its fruits all over the world.

• ESR
• antioxidant
• biochemistry
• biology
• cell biology
• chemistry
• development
• enzyme
• enzymes
• membrane
• microscopy
• protein
• proteins
• spectroscopy
• tissue

• Institute for Life Support Technology of Yamagata Technopolis Foundation, Numagi Yamagata, Yamagata, Japan

  H. Ohya-Nishiguchi

• 251 Life Science Addition Membrane Bioenergetics Group, Dept. of Molecular and Cell Biology, Berkeley, USA

  Lester Packer

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