Regulatory Peptides

1. Front Matter

   Pages i-xii

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2. Introduction

   1. Introduction

      • J. M. Polak, S. R. Bloom

      Pages 1-10

3. Techniques

   1. Regulatory peptide immunocytochemistry at light and electron microscopical levels

      • S. Van Noorden, I. M. Varndell

      Pages 11-33

   2. Aspects of measurement and analysis of regulatory peptides

      • J. M. Burrin, L. O. Uttenthal, G. P. McGregor, S. R. Bloom

      Pages 34-50

   3. Hybridisation histochemistry

      • J. D. Penschow, J. Haralambidis, P. E. Darling, I. A. Darby, E. M. Wintour, G. W. Tregear et al.

      Pages 51-69

   4. Regulatory peptide receptors: Visualization by autoradiography

      • J. M. Palacios, M. M. Dietl

      Pages 70-97

   5. Combined axonal transport tracing and immunocytochemistry for mapping pathways of peptide-containing nerves in the peripheral nervous system

      • H. C. Su, J. M. Polak

      Pages 98-112

   6. The use of cell and tissue culture techniques in the study of regulatory peptides

      • C. J. S. Hassall, T. G. J. Allen, B. S. Pittam, G. Burnstock

      Pages 113-136

   7. Quantitative analysis of autoradiograms

      • A. P. Davenport, R. G. Hill, J. Hughes

      Pages 137-153

4. General aspects

   1. Coexistence of peptides with classical neurotransmitters

      • T. Hökfelt, D. Millhorn, K. Seroogy, Y. Tsuruo, S. Ceccatelli, B. Lindh et al.

      Pages 154-179

   2. Peptides and epithelial growth regulation

      • R. A. Goodlad, N. A. Wright

      Pages 180-191

   3. Post-translational proteolytic processing of precursors to regulatory peptides

      • P. C. Andrews, K. A. Brayton, J. E. Dixon

      Pages 192-209

   4. Transgenic mouse models and peptide producing endocrine tumours: morpho-functional aspects

      • G. Rindi, E. Solcia, J. M. Polak

      Pages 210-219

5. Individual organs

   1. Endocrine cells producing regulatory peptides

      • E. Solcia, L. Usellini, R. Buffa, G. Rindi, L. Villani, A. Aguzzi et al.

      Pages 220-246

   2. Neuropeptides and the microcircuitry of the enteric nervous system

      • I. J. Llewellyn-Smith

      Pages 247-265

   3. Neuropeptides and the ocular innervation

      • R. A. Stone, Y. Kuwayama, A. M. Laties

      Pages 266-291

   4. Peptides in the mammalian cardiovascular system

      • J. Wharton, S. Gulbenkian

      Pages 292-316

   5. Regulatory peptides in the respiratory system

      • P. J. Barnes

      Pages 317-333

   6. Neuropeptides in pelvic afferent pathways

      • W. C. de Groat

      Pages 334-361

   7. Regulatory peptides in the mammalian urogenital system

      • J. Fahrenkrug, C. Palle, J. Jørgensen, B. Ottesen

      Pages 362-381

J. M. Polak and S. R. Bloom For some time Experientia has published, as a unique feature, interdis­ ciplinary multi-author reviews, giving a comprehensive overview of sub­ jects regarded as 'growing edges' of science. The enthusiasm shown by the readers was contagious and thus it was felt necessary to compile a special volume dealing with the novel aspects of regulatory peptides. This book covers some of the growing areas in regulatory peptide research and, although it is based on the original volume of Experientia, it is expanded and updated. The topic of 'regulatory peptides' is relatively young and has grown at an unprecedented pace, from the embryonic conception of 'gut hor­ mones' or 'brain neuropeptides' some 15 years ago to the realisation that these active pep tides are found, almost without exception, in every part of l8 23 the body in all vertebrate and many invertebrate species • Why the term 'regulatory peptides'? It represents a convenient label encompassing both the active peptides present in nerves, which are re­ leased as (putative) neurotransmitters, and those in endocrine cells, which act locally or at a distance as circulating hormones, these being the l8 main components of the so-called diffuse neuroendocrine or APUD 17 system • Morphological studies support this physiological viewpoint.

• Europe
• growth
• research
• science
• system
• time
• visualization

• Royal Postgraduate Medical School Department of Histochemistry, Hammersmith Hospital, London, England

  Julia M. Polak

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