Editors:
- Many of the authors are the original investigators of recombinant human G-CSF
- Key researchers provide their outlook for the next 20 years
- Describes oncological and non-oncological applications
- Includes supplementary material: sn.pub/extras
Part of the book series: Milestones in Drug Therapy (MDT)
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Table of contents (25 chapters)
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Front Matter
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Basic Science
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Front Matter
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Use of rHuG-CSF in the Oncology Setting
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Front Matter
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Use of rHuG-CSF in Non-Oncology Setting
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Front Matter
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About this book
Granulocyte colony-stimulating factor (G-CSF or GCSF) is a secreted glycoprotein that stimulates the proliferation and differentiation of granulocyte precursor cells, and induces mobilization of peripheral blood progenitor cells from the bone marrow. Development of recombinant human G-CSF has had a profound impact on the treatment of many diseases, including severe chronic neutropenia and cancer, and has enabled peripheral stem cell transplantation to supplant bone marrow transplantation in the autologous setting.
This Milestones in Drug Therapy volume describes the experience of the last 20 years of treatment with recombinant human G-CSF, including the basic science, the use of recombinant human G-CSF in both the oncology and nononcology settings, and the safety and economics of its use. Many of the authors were the original investigators of recombinant human G-CSF and other authors are key researchers who provide their outlook for the next 20 years for use of and research with recombinant human G-CSF.
Editors and Affiliations
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Amgen Inc., Thousand Oaks, USA
Graham Molineux
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MA Foote Associates, Westlake Village, USA
MaryAnn Foote
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Amgen, Inc., Thousand Oaks, USA
Tara Arvedson
Bibliographic Information
Book Title: Twenty Years of G-CSF
Book Subtitle: Clinical and Nonclinical Discoveries
Editors: Graham Molineux, MaryAnn Foote, Tara Arvedson
Series Title: Milestones in Drug Therapy
DOI: https://doi.org/10.1007/978-3-0348-0218-5
Publisher: Springer Basel
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Basel AG 2012
Hardcover ISBN: 978-3-0348-0217-8Published: 07 January 2012
Softcover ISBN: 978-3-0348-0804-0Published: 22 February 2014
eBook ISBN: 978-3-0348-0218-5Published: 05 January 2012
Series ISSN: 2296-6056
Series E-ISSN: 2296-6064
Edition Number: 1
Number of Pages: XXII, 478
Topics: Pharmacology/Toxicology, Cancer Research, Immunology, Cytokines and Growth Factors, Hematology