Replicating Vaccines

1. Front Matter

   Pages i-xiii

   PDF

2. Today’s Live Attenuated Vaccines

   1. Front Matter

      Pages 1-1

      PDF

3. Today’s live attenuated vaccines

   1. Live Vaccines and Their Role in Modern Vaccinology

      • Gordon Dougan, David Goulding, Lindsay J. Hall

      Pages 3-14

   2. Live Attenuated Vaccines: Influenza, Rotavirus and Varicella Zoster Virus

      • Harry B. Greenberg, Ann M. Arvin

      Pages 15-46

   3. Classical Live Viral Vaccines

      • Thomas

      Pages 47-69

4. Genetically Attenuated Micro-Organisms as Vaccines

   1. Front Matter

      Pages 71-71

      PDF

5. Genetically attenuated micro-organisms as vaccines

   1. Recombinant Live Vaccines to Protect Against the Severe Acute Respiratory Syndrome Coronavirus

      • Luis Enjuanes, Jose L. Nieto-Torres, Jose M. Jimenez-Guardeño, Marta L. DeDiego

      Pages 73-97

   2. Live-Attenuated Shigella Vaccines. Is Encouraging Good Enough?

      • Yves Germani, Philippe J. Sansonetti

      Pages 99-117

   3. New Generation BCG Vaccines

      • Michael V. Tullius, Marcus A. Horwitz

      Pages 119-169

6. Manipulating Host-Pathogen Interactions to Make Vaccines

   1. Front Matter

      Pages 171-171

      PDF

7. Manipulating host-pathogen interactions to make vaccines

   1. Basic Science Paves the Way to Novel Safe and Effective Pestivirus Vaccines

      • Norbert Tautz, Gregor Meyers

      Pages 173-193

   2. Live Attenuated Influenza Virus Vaccines: NS1 Truncation as an Approach to Virus Attenuation

      • Natalie Pica, Peter Palese, John Steel

      Pages 195-221

   3. An Attenuated HSV-1 Live Virus Vaccine Candidate that is Replication Competent but Defective in Epithelial Cell-to-Cell and Neuronal Spread

      • Elizabeth E. Zumbrun, Harvey M. Friedman

      Pages 223-236

   4. Live Attenuated Vaccines for Respiratory Syncytial Virus

      • Michael N. Teng

      Pages 237-259

   5. Live Attenuated Cholera Vaccines: Flagella and Reactogenicity

      • D. Ewen Cameron, John J. Mekalanos

      Pages 261-281

8. New Types of Replicating Vaccines

   1. Front Matter

      Pages 283-283

      PDF

9. New types of replicating vaccines

   1. Replication-Defective Herpes Simplex Virus Mutant Strains as Genital Herpes Vaccines and Vaccine Vectors

      • David M. Knipe

      Pages 285-298

   2. Nucleic Acid-Based Infectious and Pseudo-Infectious Flavivirus Vaccines

      • Justin A. Roby, Roy A. Hall, Alexander A. Khromykh

      Pages 299-320

   3. Application of Cleavage Activation Mutants of Influenza Virus as Live Vaccines

      • Juergen Stech, Hans-Dieter Klenk

      Pages 321-330

   4. Alphavirus Particle-Based Vaccine Vectors

      • Scott J. Balsitis, Clayton W. Beard, Peter W. Mason

      Pages 331-347

Technological advances, together with a better understanding of the molecular biology of infectious microorganisms, are creating exciting possibilities for a new generation of replicating vaccines. Historically, live vaccines have been either directly derived from a natural source or attenuated by empirical approaches using serial passages and host cell adaptation. Currently, we are witnessing a quantum leap in our technological capabilities to specifically modify the genetic make-up of viruses and bacteria, making it possible to generate improved live vaccines and to develop completely new types of replicating vaccines, such as vectored vaccines, single-round infectious vaccines and replicon vaccines. This book highlights some of the most exciting recent developments towards a new generation of replicating vaccines.

• vaccines

From the reviews:

“This book introduces the current thinking on rational attenuation and this important theme runs through the book, tying the chapters together very nicely. … Given the renaissance in vaccinology this is a timely volume which … makes judicious use of selected examples to highlight key aspects of this burgeoning field. This book is both a useful primer for students and a thought-provoking read for researchers in this field.” (Paul Duprex, Microbiology Today, November, 2011)

• Novartis Vaccines & Diagnostics, Cambridge, USA

  Philip R. Dormitzer

• Novartis Vaccines & Diagnostics, Inc., Cambridge, USA

  Christian W. Mandl

• Novartis Vaccines & Diagnostics S.r.l., Siena, Italy

  Rino Rappuoli

Policies and ethics