Overview
- Editors:
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Tomas Hökfelt
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Dept. Neuroscience, Karolinska Institute, Stockholm, Sweden
- Comprehensive collection of information on galaninergic functions and mechanisms
- Explains how a new methodological approach can lead to the detection of a new substance class
- Describes potential applications in drug development for a variety of conditions
- Useful for basic neuroscientists and clinicians alike
- Includes supplementary material: sn.pub/extras
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Table of contents (18 chapters)
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- K. Mitsukawa, X. Lu, T. Bartfai
Pages 7-23
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- S-A. Hobson, A. Bacon, C. R. Elliot-Hunt, F. E. Holmes, N. C. H. Kerr, R. Pope et al.
Pages 25-38
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- Xiao-Jun Xu, Tomas Hökfelt, Zsuzsanna Wiesenfeld-Hallin
Pages 39-50
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- J. W. Bauer, R. Lang, M. Jakab, B. Kofler
Pages 51-59
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- Helmut Butzkueven, Andrew L. Gundlach
Pages 61-69
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- Jessica R. Barson, Irene Morganstern, Sarah F. Leibowitz
Pages 87-111
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- Zaida Díaz-Cabiale, Concepción Parrado, Manuel Narváez, Carmelo Millón, Araceli Puigcerver, Kjell Fuxe et al.
Pages 113-131
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- Scott E. Counts, Sylvia E. Perez, Stephen D. Ginsberg, Elliott J. Mufson
Pages 143-162
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- Eugenia Kuteeva, Tomas Hökfelt, Tara Wardi, Sven Ove Ögren
Pages 163-181
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- J. T. Lerner, R. Sankar, A. M. Mazarati
Pages 183-194
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- Pei-Juan Shen, Andrew L. Gundlach
Pages 209-221
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- Elsie Tachie Mensah, Helene Volkoff, Suraj Unniappan
Pages 243-262
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- Catherine B. Lawrence, Gregory S. Fraley
Pages 263-280
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Back Matter
Pages 281-285
About this book
Galanin is a neuropeptide found both in the central and peripheral nervous system. The 29-amino acid peptide (named after its N-terminal glycine and C-terminal alanine) was identified in 1983 by its C-terminal amidation. This 'reverse' approach, that is to discover a substance through a distinct chemical feature, and only subsequently to characterize its biological activity, was novel and has been successful in the identification of several other peptides. After the structure of galanin was determined in 1983, functional studies were performed with material purified from natural sources until the synthetic form of the peptide became available. Galanin can act as transmitter, modulator and trophic factor, and is involved in a number of physiological processes such as hormone secretion, cardiovascular mechanisms, feeding and cognition. This peptide may also be of significance for a number of pathological processes/disorders including pain, depression, Alzheimer's disease, epilepsy, addiction and cancer. This wide diversity of actions is mediated by three galanin receptor subtypes. The studies reviewed in this volume give a fairly complete overview of the spectrum of the biological actions and functions of galanin and its receptors and on possible therapeutic applications in a number of pathological conditions.
Editors and Affiliations
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Dept. Neuroscience, Karolinska Institute, Stockholm, Sweden
Tomas Hökfelt
