Diabetic Retinopathy

1. Front Matter

   Pages i-xi

   PDF

2. Clinical Aspects of Diabetic Retinopathy

   1. Nonproliferative Diabetic Retinopathy

      • Catherine B. Meyerle, Emily Y. Chew, Frederick L. Ferris III

      Pages 3-27

   2. Proliferative Diabetic Retinopathy

      • Ronald P. Danis, Matthew D. Davis

      Pages 29-65

   3. The Epidemiology of Diabetic Retinopathy

      • Ronald Klein

      Pages 67-107

   4. Diagnostic Modalities in Diabetic Retinopathy

      • Ron Margolis, Peter K. Kaiser

      Pages 109-133

3. Pathophysiology / Basic Research

   1. In Vivo Models of Diabetic Retinopathy

      • Timothy S. Kern

      Pages 137-156

   2. Pathways of Hyperglycemia-induced Damage

      1. The Polyol Pathway and Diabetic Retinopathy

         • Lorenzi Mara, Peter J. Oates

         Pages 159-186

      2. The Role of Advanced Glycation in Diabetic Retinopathy

         • Alan W. Stitt

         Pages 187-206

      3. The Role of Protein Kinase C in Diabetic Retinopathy

         • Manvi Prakash, Jennifer K. Sun, George L. King

         Pages 207-216

      4. Oxidative Stress in Diabetic Retinopathy

         • Ruth B. Caldwell, Azza E. B. El-Remessy, Robert W. Caldwell

         Pages 217-242

   3. Pathophysiological Process in Diabetic Retinopathy

      1. Pericyte Loss in the Diabetic Retina

         • Frederick Pfister, Yuxi Feng, Hans-Peter Hammes

         Pages 245-264

      2. Capillary Dropout in Diabetic Retinopathy

         • Renu A. Kowluru, Pooi-See Chan

         Pages 265-282

      3. Neuroglial Dysfunction in Diabetic Retinopathy

         • Heather D. VanGuilder, Thomas W. Gardner, Alistair J. Barber

         Pages 283-301

      4. The Role of Inflammation in the Pathophysiology of Diabetic Retinopathy

         • Lauren E. Swenarchuk, Linda E. Whetter, Anthony P. Adamis

         Pages 303-331

      5. Vascular Permeability in Diabetic Retinopathy

         • David A. Antonetti, Heather D. VanGuilder, Cheng Mao-Lin

         Pages 333-352

      6. Retinal Neovascularization and the Role of VEGF

         • Elia J. Duh

         Pages 353-373

      7. Beyond VEGF – Other Factors Important in Retinal Neovascularization: Potential Targets in Proliferative Diabetic Retinopathy

         • Arup Das, Deepti Navaratna, Paul G. McGuire

         Pages 375-398

4. Emerging Treatments and Concepts in Diabetic Retinopathy

   1. Anti-VEGF Therapy as an Emerging Treatment for Diabetic Retinopathy

      • V. Do Diana, Julia A. Haller, Anthony P. Adamis, Striata Carla, Quan Dong Nguyen, Syed Mahmood Shah et al.

      Pages 401-422

   2. Clinical Trials in Protein Kinase C-β Inhibition in Diabetic Retinopathy

      • Jennifer K. Sun, Rola Hamam, Lloyd P. Aiello

      Pages 423-434

   3. The Role of Intravitreal Steroids in the Management of Diabetic Retinopathy

      • Mark C. Gillies

      Pages 435-448

Diabetic retinopathy is the most common microvascular complication of diabetes. It remains a major cause of new-onset visual loss in the United States and other industrialized nations. In Diabetic Retinopathy, Elia Duh and a panel of internationally recognized experts comprehensively assess the current state of knowledge regarding the clinical management of DR as well as its underlying mechanisms. The authors outline the current understanding of diabetic retinopathy from the perspective of clinical practice, while reviewing the multi-factorial pathogenesis and pathophysiology of DR from the standpoint of biomedical research. Also included is a discussion of emerging concepts relating to the management and treatment of DR. Informative and highly-practical, Diabetic Retinopathy provides ophthalmologists, diabetologists, endocrinologists, and internists with a highly readable guide not only to understanding diabetic retinopathy, but also to its optimal clinical management.

• Diabetes
• Microvascular
• Oxidative Stress
• Retinal Neovascularization
• Retinopathy
• Therapeutic Strategies
• Vascular Permeability
• steroids

From the reviews:

"This is an extremely comprehensive book covering the clinical features, pathophysiology, and treatment of one of the most significant causes of blindness in the world. … The book has wide appeal, to endocrinologists, general ophthalmologists, and most importantly to practicing retina specialists. … This book offers a balance between the clinical features and basic science aspects of diabetic retinopathy. It is a worthy addition to the collection of books covering this topic." (Anton Orlin, Doody’s Review Service, June, 2009)

"This is a recent volume … describing a broad problems related to diabetic retinopathy which is the most common microvascular complication of diabetes and possibly a major cause of new-onset visual loss. … In this unique monograph namely three topics are treated and discussed by fifty outstanding and well known experts from three continents." (Endocrine Regulations, August, 2009)

“Part of the Series Contemporary Diabetes, this volume reviews in 3 parts and 21 chapters new advancement in the pathophysiology and treatment of this disease. Of special interest to endocrinologists … . With many color illustrations and many references.” (Pediatric Endocrinology Review, September, 2009)

• The Wilmer Ophthalmological Institute, Johns Hopkins University School of Medicine, Baltimore, USA

  Elia J. Duh

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