Sensitization of Cancer Cells for Chemo/Immuno/Radio-therapy

1. Front Matter

   Pages i-xxi

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2. Sensitization via Membrane-Bound Receptors

   1. Sensitization of Epithelial Cancer Cells with Human Monoclonal Antibodies

      • H. Peter Vollmers, Stephanie Brändlein

      Pages 3-11

   2. Targeting the Transferrin Receptor to Overcome Resistance to Anti-Cancer Agents

      • Tracy R. Daniels, Isabel I. Neacato, Gustavo Helguera, Manuel L. Penichet

      Pages 13-27

   3. Chemo-Immunosensitization of Resistant B-NHL as a Result of Rituximab (anti-CD20 mAb)-Mediated Inhibition of Cell Survival Signaling Pathways

      • Benjamin Bonavida, Ali R. Jazirehi, Mario I. Vega, Sara Huerta-Yepez, Kazuo Umezawa, Eriko Suzuki

      Pages 29-39

   4. Agents that Regulate DR5 and Sensitivity to TRAIL

      • Tatsushi Yoshida, Toshiyuki Sakai

      Pages 41-49

   5. Proteasome Inhibition: Potential for Sensitization of Immune Effector Mechanisms in Cancer

      • Milad Motarjemi, William H. D. Hallett, Minghui Li, William J. Murphy

      Pages 51-60

3. Sensitization via Inhibition of Cell Survival Pathways (Excluding Apoptotic Signaling Pathways)

   1. Angiogenesis Inhibitors as Enabling Agents for the Chemotherapeutic Treatment of Metastatic Disease

      • Giulio Francia, Urban Emmenegger, Robert S. Kerbel

      Pages 63-80

   2. Targeting Survival Cascades Induced by Activation of Ras/Raf/MEK/ERK and PI3K/Akt Pathways to Sensitize Cancer Cells to Therapy

      • James A. McCubrey, Richard A. Franklin, Fred E. Bertrand, Jackson R. Taylor, William H. Chappell, Melissa L. Midgett et al.

      Pages 81-114

   3. Histone Deacetylase Inhibitors and Anticancer Activity

      • Roberto R. Rosato, Steven Grant

      Pages 115-131

   4. Eicosanoids and Resistance of Cancer Cells to Chemotherapeutic Agents

      • Andrey Sorokin

      Pages 133-156

4. Sensitization via Transcription Factors

   1. The RKIP and STAT3 Axis in Cancer Chemotherapy: Opposites Attract

      • Devasis Chatterjee, Edmond Sabo, Murray B. Resnick, Kam C. Yeung, Y. Eugene Chin

      Pages 159-174

   2. Targeting Transcription Factors with Decoy Oligonucleotides: Modulation of the Expression of Genes Involved in Chemotherapy Resistance of Tumor Cells

      • Roberto Gambari

      Pages 175-187

   3. p53 Inhibitors as Cancer Sensitizing Agents

      • Flavio Maina, Rosanna Dono

      Pages 189-202

   4. Nitric Oxide—Induced Immunosensitization to Apoptosis by Fas-L and TRAIL

      • Benjamin Bonavida, Sara Huerta-Yepez, Mario I. Vega, Demetrios A. Spandidos, Stravoula Baritaki

      Pages 203-210

   5. Natural Agents That Can Sensitize Tumor Cells to Chemotherapy and Radiation Therapy

      • Ganesh Jagetia, Sunil Krishnan Krishnan, Bharat B. Aggarwal

      Pages 211-240

5. Sensitization via Targeting Apoptotic Pathways

   1. Inhibitors of the Bcl-2 Protein Family as Sensitizers to Anticancer Agents

      • Daniel E. Johnson

      Pages 243-261

   2. Therapeutic Targeting of Apoptosis in Cancer

      • Timothy R. Wilson, Daniel B. Longley, Patrick G. Johnston

      Pages 263-278

   3. Peptides and Peptidomimetics as Cancer Therapy Sensitizing Agents

      • Shantanu Banerji, Sudharsana Rao Ande, Subbareddy Maddika, Versha Banerji, Iran Rashedi, Neil W. Owens et al.

      Pages 279-303

   4. Non-Peptidic Mimetics as Cancer-Sensitizing Agents

      • Ruud P. M. Dings, Mark Klein, Kevin H. Mayo

      Pages 305-325

   5. Sensitization of Cancer Cells to Cancer Therapies by Isoflavone and Its Synthetic Derivatives

      • Fazlul H. Sarkar, Yiwei Li

      Pages 327-335

Cancer chemotherapy can be traced back to the 1940’s and since then the world has witnessed the discovery and the important application of several new drugs. The successes of combination chemotherapy suggested that all cancers can be treated provided that the correct combination of drugs at the correct doses and correct intervals are established. However, with time, tumor cells develop mechanisms of resistance to apoptosis and no longer respond to the majority of cytotoxic therapies. Sensitization of Cancer Cells for Chemo/Immuno/Radio-therapy, edited by Benjamin Bonavida, reviews novel approaches developed to reverse tumor cell resistance to chemo/immuno/radio-therapy and the use of various sensitizing agents in combination with various cytotoxics. Such sensitizing agents target gene products that regulate resistance and therefore identify novel targets for drug development. This book also introduces several of the current approaches that have been developed by established investigators in the field that are aimed at overcoming resistance. This book is the first that compiles studies on tumor cell sensitization and is useful for students, scientists, clinicians and pharmaceutical companies.

• Sensitization
• angiogenesis
• apoptosis
• apoptotic
• chemotherapeutic agents
• inhibitors
• membrane-bound receptors
• metastatic disease
• pathways
• positron emission tomography
• siRNA
• transcription factors

From the reviews: “This book introduces emerging strategies, potential signaling pathways and biomolecules as key targets to sensitize resistant cancers. … detailed information and data can be obtained from the references listed at the end of each chapter. This book helps chemists to enrich their biological insight, and biologists to acquire new chemical strategies in reversing cancer resistance. … the book is also recommended to students in these fields. For scientists in industry and academia, and clinicians, this book provides an overview of current approaches … .” (Yoshihiko Kotake, ChemMedChem, Vol. 4, 2009)

• University of California at Los Angeles, Los Angeles, USA

  Benjamin Bonavida

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