Principles of Pulmonary Protection in Heart Surgery

1. Front Matter

   Pages i-xx

   PDF

2. General Concepts

   1. Front Matter

      Pages 1-1

      PDF

   2. Anatomy of the Lungs

      • Colleen Gaughan, Anthony L. Panos

      Pages 3-8

   3. Respiratory Physiology

      • Jesús Armando Sánchez-Godoy

      Pages 9-26

   4. Histological Features of Lungs

      • Vera Luiza Capelozzi, Edwin Roger Parra

      Pages 27-32

   5. Cellular and Molecular Aspects of Lung Function, its Control and Regulation

      • Jesús Armando Sánchez Godoy, Alain Riveros Rivera

      Pages 33-43

   6. Imaging Evaluation of the Thorax

      • Gilberto Szarf, Henrique M. Lederman

      Pages 45-52

3. Ischemia-Reperfusion Injury

   1. Front Matter

      Pages 53-53

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   2. Endothelial Protection During Heart Surgery and Lung Transplantation

      • Qin Yang, Guo-Wei He

      Pages 55-65

   3. Vascular Endothelial Growth Factor and Pulmonary Injury

      • Vineet Bhandari

      Pages 67-73

   4. Aprotinin Decreases Lung Reperfusion Injury and Dysfunction

      • Hartmuth B. Bittner, Peter S. Dahlberg, Cynthia S. Herrington, Friedrich W. Mohr

      Pages 75-79

   5. Effects of Prostaglandin E1 and Nitroglycerin on Lung Preservation

      • Stefano Salizzoni, Yoshiko Toyoda, Yoshiya Toyoda

      Pages 81-89

   6. Endothelin and Ischemia-Reperfusion Injury

      • Matthias Gorenflo

      Pages 91-96

   7. L-Arginine and Ischemia-Reperfusion Injury

      • Yanmin Yang, Jiming Cai

      Pages 97-106

   8. The Role of Nitric Oxide in Pulmonary Ischemia-Reperfusion Injury

      • Peter Donndorf, Alexander Kaminski, Gustav Steinhoff

      Pages 107-112

   9. Activity of Glutathione-Related Enzymes in Ischemia and Reperfusion Injury

      • Emmanuele Tafuri, Andrea Mezzetti, Antonio Maria Calafiore, Francesco Cipollone

      Pages 113-120

   10. Heart Histopathology in Ischemia-Reperfusion Injury

       • Paulo Sampaio Gutierrez, Márcia Marcelino de Souza Ishigai

       Pages 121-127

   11. Beating Heart Surgery and Pulmonary Ischemia and Reperfusion Injury

       • Tomas A. Salerno, Francisco Igor B. Macedo, Maria R. Suarez, Marco Ricci, Edward Gologorsky

       Pages 129-134

4. Pulmonary Hypertension

   1. Front Matter

      Pages 135-135

      PDF

   2. Mechanisms of Pulmonary Edema

      • Si Pham, Eddie Manning

      Pages 137-145

Over the past ?fty years, advanced techniques and strategies have arisen in the ?eld of myocardial protection. Meticulous trials, focusing on pulmonary protection during heart surgery requiring cardiopulmonary bypass (CPB), have been missing. This te- book is intended to serve as a useful tool to spread information on strategies for lung protection during heart surgery with CPB. Emphasis on pulmonary protection will be turned to lung perfusion as an adjunct for minimizing the deleterious effects of pulmonary ischemia-reperfusion injury in heart surgery. Many renowned authors have contributed by presenting their expe- ence on lung perfusion in basic research and clinical trials. Furthermore, they have enlightened the quality of this textbook with new ideas, concepts, and future perspectives. The scope of this textbook is of interest to different professionals, such as card- vascular surgeons, pulmonary surgeons, transplantation physicians, cardiothoracic anesthesiologists, intensive care physicians, cardiothoracic fellows, radiologists, basic sciences physicians, cardiologists, pulmonary medicine physicians, perfusi- ists, nurses, students, and researchers. This textbook has 7 sections, aimed at addressing general and speci?c aspects of pulmonary protection during heart surgery with CPB. The ?rst section on general concepts provides information about anatomic, physiologic, histologic, molecular, and radiologic considerations regarding the lungs. The second section focuses on ischemia-reperfusion injury and is composed of several interesting chapters, addressing the basic science aspects of pulmonary p- tection, as well as experimental and clinical experiences from different heart surgery centers worldwide.

• Bypass
• anatomy
• circulation
• congenital heart disease
• embolism
• heart
• hypertension
• lung
• transplantation
• thoracic surgery

• Federal University of Sao Paulo, Sao Paulo, Brazil

  Edmo Atique Gabriel

• University of Miami, Miami, USA

  Tomas Salerno

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