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Epigenetic Aspects of Chronic Diseases

  • Book
  • © 2011

Overview

Editors:
  1. Helmtrud I. Roach

    1. , General Hospital, University of Southampton, Southampton, United Kingdom

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    You can also search for this editor in PubMed   Google Scholar

  2. Felix Bronner

    1. Health Center, Dept. Pharmacology, University of Connecticut, Farmington, USA

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    You can also search for this editor in PubMed   Google Scholar

  3. Richard O.C. Oreffo

    1. Developmental Origins Health and Disease, University of Southampton, Southampton, United Kingdom

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    You can also search for this editor in PubMed   Google Scholar

  • Cutting edge of current research – brings up-to-date information on how epigenetics contributes to a disease

  • Well illustrated with color images including cartoons to help understand complex mechanisms

  • Coverage of many diseases within one volume assists and stimulates cross-referencing between different diseases

  • Careful editing of each chapter ensures consistency and clarity of language

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Table of contents (15 chapters)

  1. Front Matter

    Pages i-xvii
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  2. Epigenetics and Chronic Diseases: An Overview

    • Rebecca Smith, Jonathan Mill
    Pages 1-20

  3. Techniques to Study DNA Methylation and Histone Modification

    • Ester Lara, Vincenzo Calvanese, Agustin F. Fernandez, Mario F. Fraga
    Pages 21-39

  4. Mechanisms of Epigenetic Gene Silencing

    • Marie-Pierre Lambert, Zdenko Herceg
    Pages 41-53

  5. Mechanisms of Epigenetic Gene Activation in Disease: Dynamics of DNA Methylation and Demethylation

    • Thierry Grange, Edio Eligio Lourenço
    Pages 55-73

  6. The Role of Histone Demethylases in Disease

    • Paul Cloos
    Pages 75-93

  7. Autoimmune Diseases

    • Travis Hughes, Amr H. Sawalha
    Pages 95-106

  8. Epigenetics of Rheumatoid Arthritis

    • Aleksander M. Grabiec, Paul P. Tak, Kris A. Reedquist
    Pages 107-119

  9. DNA Methylation Changes in Osteoarthritis

    • Helmtrud I. Roach
    Pages 121-134

  10. Epigenetics and Type 2 Diabetes

    • Charlotte Ling, Tina Rönn, Marloes Dekker Nitert
    Pages 135-145

  11. Epigenetic Regulation of Asthma and Allergic Diseases

    • Andrew L. Durham, Ian M. Adcock
    Pages 147-161

  12. Epigenetics in Psychiatry

    • Hamid Mostafavi-Abdolmaleky, Stephen J. Glatt, Ming T. Tsuang
    Pages 163-174

  13. Epigenetics and Late-Onset Alzheimer’s Disease

    • Axel Schumacher, Syed Bihaqi, Nasser H. Zawia
    Pages 175-186

  14. Epigenetic Mechanisms in the Developmental Origins of Adult Disease

    • Keith M. Godfrey, Karen A. Lillycrop, Mark A. Hanson, Graham C. Burdge
    Pages 187-204

  15. Targeting Histone Deacetylases in Chronic Obstructive Pulmonary Disease

    • Peter J. Barnes
    Pages 205-215

  16. Clinical Trials of Epigenetic Modifiers in the Treatment of Myelodysplastic Syndrome

    • Lauren C. Suarez, Steven D. Gore
    Pages 217-229

  17. Back Matter

    Pages 231-236
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Keywords

About this book

Epigenetic Aspects of Chronic Diseases assembles in comprehensive form what is known about the role of epigenetics in chronic disease development. This book provides new insights into treatment, including modulation of epigenetic regulation. Each chapter gives an outline of a respective disease, explains why epigenetics may be involved in the disease process and then presents the evidence of how changes in epigenetic status contribute to initiation and progress of the disease. The final chapters look towards future therapeutic treatment, based on manipulation of epigenetic aspects. Written by widely published experts, Epigenetic Aspects of Chronic Diseases is a valuable reference tool for clinicians and researchers who investigate and treat chronic diseases, as well as health care personnel, post-doctoral fellows and medical or dental students.

Editors and Affiliations

  • , General Hospital, University of Southampton, Southampton, United Kingdom

    Helmtrud I. Roach

  • Health Center, Dept. Pharmacology, University of Connecticut, Farmington, USA

    Felix Bronner

  • Developmental Origins Health and Disease, University of Southampton, Southampton, United Kingdom

    Richard O.C. Oreffo

Bibliographic Information

  • Book Title: Epigenetic Aspects of Chronic Diseases

  • Editors: Helmtrud I. Roach, Felix Bronner, Richard O.C. Oreffo

  • DOI: https://doi.org/10.1007/978-1-84882-644-1

  • Publisher: Springer London

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer-Verlag London Limited 2011

  • Hardcover ISBN: 978-1-84882-643-4Published: 02 April 2011

  • Softcover ISBN: 978-1-4471-5910-0Published: 26 September 2014

  • eBook ISBN: 978-1-84882-644-1Published: 01 April 2011

  • Edition Number: 1

  • Number of Pages: XVII, 236

  • Topics: Human Genetics, Medical Biochemistry, Internal Medicine

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