Editors:
- Includes cutting-edge methods and protocols
- Provides step-by-step detail essential for reproducible results
- Contains key notes and implementation advice from the experts
- Includes supplementary material: sn.pub/extras
Part of the book series: Methods in Molecular Biology (MIMB)
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Table of contents (22 protocols)
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Front Matter
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Background
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Front Matter
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DNA as a Tool to Modulate Drug Targets
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Front Matter
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RNA Interference: From Design to Data Analysis
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Front Matter
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Protein-Focused Technologies
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Front Matter
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Innovative Cell Culture Techniques to Mimic Tissue Microenvironments
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Front Matter
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About this book
The major reason for the elevated costs of drug development in the pharmaceutical industry is the high attrition rate. In Target Identification and Validation in Drug Discovery: Methods and Protocols, expert researchers in the field detail many of the methods which are now commonly used to identify and validate new target. These include methods and approaches covering biochemical, cell based, in vivo models and translational methods. Chapters also include selected case reports that demonstrate the integration of these technologies to real life experiences and to demonstrate the multiple use of more than one technology to increase knowledge on a specific target. These Written in the highly successful Methods in Molecular Biologyâ„¢ series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory.
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Thorough and intuitive, Target Identification and Validation in Drug Discovery: Methods and Protocols contains a comprehensive list of essential methods and clear protocols to follow.
Editors and Affiliations
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Director, Department of Pharmacology, Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria
Jurgen Moll
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Project and Team Leader, Cell Biology, Nerviano Medical Sciences, Nerviano, Italy
Riccardo Colombo
Bibliographic Information
Book Title: Target Identification and Validation in Drug Discovery
Book Subtitle: Methods and Protocols
Editors: Jurgen Moll, Riccardo Colombo
Series Title: Methods in Molecular Biology
DOI: https://doi.org/10.1007/978-1-62703-311-4
Publisher: Humana Totowa, NJ
eBook Packages: Springer Protocols
Copyright Information: Springer Science+Business Media New York 2013
Hardcover ISBN: 978-1-62703-310-7Published: 23 February 2013
Softcover ISBN: 978-1-4939-6278-5Published: 19 August 2016
eBook ISBN: 978-1-62703-311-4Published: 26 February 2013
Series ISSN: 1064-3745
Series E-ISSN: 1940-6029
Edition Number: 1
Number of Pages: XV, 371