Active Surveillance for Localized Prostate Cancer

1. Front Matter

   Pages i-xi

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2. The Problem of Cancer Overdiagnosis and Overtreatment

   • Laurence Klotz

   Pages 1-7

3. Patient Selection for Active Surveillance

   • John B. Eifler, H. Ballentine Carter

   Pages 9-21

4. Predicting High-Risk Disease Using Tissue Biomarkers

   • Michael J. Donovan, Carlos Cordon-Cardo

   Pages 23-34

5. Predicting High-Risk Disease Using Serum and DNA Biomarkers

   • Danny Vesprini, Robert Nam

   Pages 35-54

6. Triggers for Intervention in Men on Surveillance

   • S. Y. Jackie Sham, Chris Parker

   Pages 55-65

7. The Role of MRI in Active Surveillance

   • Caroline M. Moore, Clare Allen, Mark Emberton

   Pages 67-80

8. Active Surveillance: The European Experience

   • Meelan Bul, Monique J. Roobol, Chris H. Bangma

   Pages 81-94

9. Active Surveillance: The Canadian Experience

   • Laurence Klotz

   Pages 95-105

10. Psychosocial Aspects of AS

    • Meredith Wallace Kazer, Dwanna M. Ward-Boahen, David M. Latini, Donald E. Bailey Jr.

    Pages 107-119

11. Statistical Considerations for Patient Selection and Triggers for Intervention in Active Surveillance

    • Andrew J. Vickers

    Pages 121-129

12. Interpreting PSA Kinetics Using GLMM Technique

    • Liying Zhang, Laurence Klotz

    Pages 131-137

13. The Potential Benefits of Diet and Physical Activity Among Active Surveillance Patients with Low-Burden Prostate Cancer

    • Stacey A. Kenfield, J. Kellogg Parsons, June M. Chan

    Pages 139-152

14. The Role of 5α-Reductase Inhibitors (5-ARIs) in Expectant Management of Low-Risk Prostate Cancer

    • David Margel, Neil Fleshner

    Pages 153-156

15. Urologists’ Opinion on Active Surveillance: USA Versus the Netherlands

    • Lionne D. F. Venderbos, Chris H. Bangma, Ida J. Korfage

    Pages 157-168

16. Clinical “Pearls” in Managing Patients on Surveillance

    • Laurence Klotz

    Pages 169-172

17. Active Surveillance, Focal Therapy, and the Future

    • Mark Emberton

    Pages 173-178

18. The Economics of Active Surveillance for Prostate Cancer

    • Marc A. Dall’Era, Christopher P. Evans

    Pages 179-185

19. The Future of Active Surveillance

    • Sima P. Porten, Jared M. Whitson, Peter R. Carroll

    Pages 187-199

20. Back Matter

    Pages 201-208

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Active Surveillance for Localized Prostate Cancer: A New Paradigm for Clinical Management will serve as a useful resource for physicians dealing with, and interested in, this complex and evolving branch of prostate cancer management.  The book will also be of interest to scientifically literate patients and their families.   The volume provides an introduction to the concept of active surveillance in oncology in general and prostate cancer specifically. The primary focus is to provide a comprehensive guide to the management of patients on surveillance. The volume covers the many complexities and nuances to this approach including, patient selection, risk assessment, how to overcome 'cancer hysteria' when counseling patients, identifying appropriate triggers for intervention, use of PSA kinetics and MR imaging information, technique and frequency of biopsies, secondary prevention interventions, and the relative roles of surveillance and focal therapy.

• GLMM technique
• GLMM technique
• MRI and surveillance
• MRI and surveillance
• PSA kinetics
• PSA kinetics
• Risk stratification
• Risk stratification

From the reviews:

“The concept of active surveillance (AS) was developed by Klotz, with the aim of limiting the risk of overtreatment in patients with low-risk cancers, while providing timely radical treatment for those requiring it. Currently, this concept is supported by an increasing number of urologists. … This excellent overview dedicated to AS fills a lack in the literature. … this textbook can be recommended to all physicians involved in prostate cancer management.” (European Urology Today, Vol. 25 (2), March-May, 2013)

“This book summarizes the current worldwide experience with active surveillance for prostate cancer. … this book is appropriate for primary care physicians, surgeons, medical oncologists, radiation oncologists, pathologists, radiologists, psychiatrists, and psychologists. Furthermore, it would be valuable to the general audience and patients as it clearly describes the role and implications of active surveillance in the treatment of prostate cancer. … I strongly recommend this book to any clinician whose practice involves the treatment of patients with prostate cancer in any capacity.” (Sanjay Kasturi, Doody’s Book Reviews, October, 2012)

• University of Toronto, Sunnybrook Health Sciences Centre, Division of Urology, Toronto, Canada

  Laurence Klotz

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