Cytoskeleton and Human Disease

1. Front Matter

   Pages 1-1

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2. Basics of the Cytoskeleton

   1. Front Matter

      Pages 1-1

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   2. ACTIN

      • Vera Dugina, Richard Arnoldi, Paul A. Janmey, Christine Chaponnier

      Pages 3-28

   3. Microtubules

      • Pavel Dráber, Eduarda Dráberová

      Pages 29-53

   4. The Kinesin Superfamily

      • Linda Wordeman

      Pages 55-72

   5. Basics of the Cytoskeleton: Myosins

      • Omar A. Quintero, Judy E. Moore, Christopher M. Yengo

      Pages 73-100

3. Actin and Disease

   1. Front Matter

      Pages 101-101

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   2. The Actin Cytoskeleton and Membrane Organisation in T Lymphocytes

      • Rhea Cornely, Thomas Grewal, Katharina Gaus

      Pages 103-121

   3. Thin Filament Diseases of Striated Muscle

      • Anthony J. Kee, Edna C. Hardeman

      Pages 123-140

   4. Filamins and Disease

      • Stephen P. Robertson, Philip B. Daniel

      Pages 141-158

   5. LIM Kinase and Cancer Metastasis

      • Alice Schofield, Ora Bernard

      Pages 159-168

   6. Actin Mutations and Deafness

      • Matías Morín, Fernando Mayo, Felipe Moreno, Miguel A. Moreno-Pelayo

      Pages 169-180

   7. Therapeutic Targeting of the Actin Cytoskeleton in Cancer

      • Teresa Bonello, Jason Coombes, Galina Schevzov, Peter Gunning, Justine Stehn

      Pages 181-200

4. Microtubules and Disease

   1. Front Matter

      Pages 201-201

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   2. Microtubules as a Target in Cancer Therapy

      • April L. Risinger, Susan L. Mooberry

      Pages 203-221

   3. Microtubules, Drug Resistance, and Tumorigenesis

      • Joshua A. McCarroll, Maria Kavallaris

      Pages 223-240

   4. Posttranslational Modifications of Tubulin

      • Suzan K. Chao, Chia-Ping H. Yang, Susan Band Horwitz

      Pages 241-257

   5. Stathmin and Cancer

      • Dominic Chi Hiung Ng, Frances Byrne

      Pages 259-284

   6. The Biology and Pathobiology of Tau Protein

      • Garth F. Hall

      Pages 285-313

   7. Tubulin-Related Malformations of Cortical Development

      • Xavier H. Jaglin, Jamel Chelly, Nadia Bahi-Buisson

      Pages 315-341

The cytoskeleton is comprised of a variety of specialized proteins, and is a dynamic structure that is involved in the majority of key cellular events. There is increasing interest in the role of the cytoskeleton in human disease. This volume brings together human disease states where cytoskeletal disruptions are driving disease. Our emerging understanding of the molecular and cellular events that drive cytoskeletal mediated diseases including cancer, heart disease, myopathies and skin disorders, are also helping shape targeted therapeutic approaches to treating these diseases.

• Cell Biology
• Cytoskeleton
• Disease
• Human
• Kavallaris
• Cell Cycle Analysis

• Australia for Medical Research, Iron Metabolism Program, Children's Cancer Institute, Randwick, Australia

  Maria Kavallaris

Maria Kavallaris, Ph.D. is Head of the Tumour Biology and Targeting Program and a National Health and Medical Research Council Senior Research Fellow at the Children's Cancer Institute Australia. She also holds appointments as Director of the Australian Centre for Nanomedicine and Professor at the University of New South Wales. Maria has made fundamental contributions in identifying mechanisms of action and resistance to anticancer drugs that target tubulin and discovering new cytoskeleton interactions in cell division and tumor formation. She obtained her Ph.D. from the University of New South Wales and undertook her postdoctoral studies as an International Agency for Cancer Research Fellow at the Albert Einstein College of Medicine, New York. She has served on numerous grant review panels, scientific advisory committees, pharmaceutical advisory boards and is a past President of the Australian Society for Medical Research. Maria is a Director of the Australian Institute for Policy and Science.

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