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Animal Models of Acute Neurological Injuries II

Injury and Mechanistic Assessments, Volume 2

  • Book
  • © 2012

Overview

Editors:
  1. Jun Chen

    1. School of Medicine, University of Pittsburgh, Pittsburgh, USA

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  2. Xiao-Ming Xu

    1. School of Medicine, Stark Neurosciences Res. Inst., Indiana University, Indianapolis, USA

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    You can also search for this editor in PubMed   Google Scholar

  3. Zao C. Xu

    1. School of Medicine, Department of Anatomy & Cell Biology, Indiana University, Indianapolis, USA

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    You can also search for this editor in PubMed   Google Scholar

  4. John H. Zhang

    1. School of Medicine, Dept. Neurosurgery, Loma Linda University, Loma Linda, USA

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    You can also search for this editor in PubMed   Google Scholar

  • Presents the material in a disease/disorder oriented manner for convenient reference
  • Offers both recommended, established techniques and alternative methods that have their own special utility
  • Features key tips and implementation advice to ensure successful results
  • Includes supplementary material: sn.pub/extras

Part of the book series: Springer Protocols Handbooks (SPH)

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Table of contents (52 protocols)

  1. Front Matter

    Pages i-xviii
    Download chapter PDF

  2. Introduction (Parts I–III)

    • R. Anne Stetler, Miguel A. Perez-Pinzon
    Pages 1-3

  3. Global Cerebral Ischemia

    1. Front Matter

      Pages 5-5
      Download chapter PDF

  4. Global Cerebral Ischemia (GCI)

    1. Morphological Assessments of Global Cerebral Ischemia: Viable Cells

      • Peiying Li
      Pages 7-17

    2. Morphological Assessments of Global Cerebral Ischemia: Degenerated Cells

      • Peiying Li
      Pages 19-28

    3. Morphological Assessments of Global Cerebral Ischemia: Electron Microscopy

      • Irina S. Balan, Tibor Kristian, Chunli Liu, Andrew J. Saladino, Bingren Hu
      Pages 29-46

    4. Biochemical and Molecular Biological Assessments of Global Cerebral Ischemia: mRNA

      • R. Anne Stetler, Yu Gan
      Pages 47-59

    5. Biochemical and Molecular Biological Assessments of Global Cerebral Ischemia: Protein

      • Yu Gan, R. Anne Stetler
      Pages 61-66

    6. Neurobehavioral Assessments of Global Cerebral Ischemia

      • Pinar Kendigelen, Dandan Sun, Pelin Cengiz
      Pages 67-80

    7. Assessment of Neurogenesis in the Dentate Gyrus After Global or Focal Ischemia

      • Wei Liu, Jialing Liu
      Pages 81-90

  5. Focal Cerebral Ischemia

    1. Front Matter

      Pages 91-91
      Download chapter PDF

  6. Focal Cerebral Ischemia (FCI)

    1. Infarct Measurement in Focal Cerebral Ischemia: TTC Staining

      • Feng Zhang, Jun Chen
      Pages 93-98

    2. Morphological Assessments of Focal Cerebral Ischemia: White Matter Injury

      • Feng Zhang, Lyanne C. Schlichter
      Pages 99-105

    3. Blood Flow Reduction: Laser Doppler, 14C-IAP

      • Feng Zhang, Steven H. Graham, Jun Chen
      Pages 107-114

    4. Biochemical and Molecular Biological Assessments of Focal Cerebral Ischemia: mRNA and MicroRNA

      • Yu Gan, R. Anne Stetler
      Pages 115-129

    5. Biochemical and Molecular Biological Assessments of Focal Cerebral Ischemia: Protein

      • R. Anne Stetler, Yu Gan
      Pages 131-138

    6. Assessments of Inflammation After Focal Cerebral Ischemia

      • Xiaoming Hu, Jun Chen
      Pages 139-148

    7. Neurobehavioral Assessments of Focal Cerebral Ischemia: Sensorimotor Deficit

      • Yejie Shi, Dandan Sun
      Pages 149-156

    8. Neurobehavioral Assessments of Focal Cerebral Ischemia: Cognitive Deficit

      • Yejie Shi, Dandan Sun
      Pages 157-162

    9. Assessment of Neurogenesis in Models of Focal Cerebral Ischemia

      • Feng-Yan Sun, Xiao Sun, Ji-Jiang Wang, Qiu-Wan Zhang, Yong-Quan Wang
      Pages 163-179
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Keywords

About this book

The successful previous volume on this topic provided a detailed benchwork manual for the most commonly used animal models of acute neurological injuries including cerebral ischemia, hemorrhage, vasospasm, and traumatic brain and spinal cord injuries.  Animal Models of Acute Neurological Injuries II: Injury and Mechanistic Assessments aims to collect chapters on assessing these disorders from cells and molecules to behavior and imaging. These comprehensive assessments are the key for understanding disease mechanisms as well as developing novel therapeutic strategies to ameliorate or even prevent damages to the nervous system.  Volume 2 examines global cerebral ischemia, focal cerebral ischemia, and neonatal hypoxia-ischemia, as well as intensive sections covering traumatic brain injury and spinal cord injury.  Designed to provide both expert guidance and step-by-step procedures, chapters serve to increase understanding in what, why, when, where, and how a particular assessment is used.

 

Accessible and essential, Animal Models of Acute Neurological Injuries II: Injury and Mechanistic Assessments will be useful for trainees or beginners in their assessments of acute neurological injuries, for experienced scientists from other research fields who are interested in either switching fields or exploring new opportunities, and for established scientists within the field who wish to employ new assessments.

Reviews

“This an atlas-text ‘protocols’ step by step explanation of animal cerebral ischemia, brain trauma, & spinal cord injury. … I recommend this book for ischemia and trauma students and physiology students.” (Joseph J. Grenier, Amazon.com, October, 2015)

Editors and Affiliations

  • School of Medicine, University of Pittsburgh, Pittsburgh, USA

    Jun Chen

  • School of Medicine, Stark Neurosciences Res. Inst., Indiana University, Indianapolis, USA

    Xiao-Ming Xu

  • School of Medicine, Department of Anatomy & Cell Biology, Indiana University, Indianapolis, USA

    Zao C. Xu

  • School of Medicine, Dept. Neurosurgery, Loma Linda University, Loma Linda, USA

    John H. Zhang

Bibliographic Information

  • Book Title: Animal Models of Acute Neurological Injuries II

  • Book Subtitle: Injury and Mechanistic Assessments, Volume 2

  • Editors: Jun Chen, Xiao-Ming Xu, Zao C. Xu, John H. Zhang

  • Series Title: Springer Protocols Handbooks

  • DOI: https://doi.org/10.1007/978-1-61779-782-8

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media, LLC 2012

  • Hardcover ISBN: 978-1-61779-781-1Published: 11 April 2012

  • Softcover ISBN: 978-1-4939-6052-1Published: 23 August 2016

  • eBook ISBN: 978-1-61779-782-8Published: 11 April 2012

  • Series ISSN: 1949-2448

  • Series E-ISSN: 1949-2456

  • Edition Number: 1

  • Number of Pages: XVIII, 718

  • Topics: Neurosciences, Neurology, Animal Models

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