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  • Book
  • © 2012

Genetic Toxicology

Principles and Methods

  • Covers the scientific basis, the methodologies, and the applications of the methods in clear detail
  • Features step-by-step, laboratory ready protocols
  • Includes expert tips and implementation advice to ensure successful results
  • Includes supplementary material: sn.pub/extras

Part of the book series: Methods in Molecular Biology (MIMB, volume 817)

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Table of contents (18 protocols)

  1. Front Matter

    Pages i-xvi
  2. Bacterial Mutagenicity Assays: Test Methods

    • David Gatehouse
    Pages 21-34
  3. The Mouse Lymphoma Assay

    • Melvyn Lloyd, Darren Kidd
    Pages 35-54
  4. The In Vitro Micronucleus Assay

    • Ann T. Doherty
    Pages 121-141
  5. The In Vitro and In Vivo Comet Assays

    • Brian Burlinson
    Pages 143-163
  6. Methods for the Detection of DNA Adducts

    • Karen Brown
    Pages 207-230
  7. The GADD45a-GFP GreenScreen HC Assay

    • Richard M. Walmsley, Matthew Tate
    Pages 231-250
  8. Cytogenetic In Vivo Assays in Somatic Cells

    • Ann T. Doherty, Adi Baumgartner, Diana Anderson
    Pages 271-304
  9. Cytogenetic Methods in Human Biomonitoring: Principles and Uses

    • Raluca A. Mateuca, Ilse Decordier, Micheline Kirsch-Volders
    Pages 305-334
  10. The Measurement of Induced Genetic Change in Mammalian Germ Cells

    • Ilse-Dore Adler, Francesca Pacchierotti, Antonella Russo
    Pages 335-375
  11. Analysis of Genotoxicity Data in a Regulatory Context

    • Ian de G. Mitchell, David O. F. Skibinski
    Pages 399-417
  12. Back Matter

    Pages 419-433

About this book

The evaluation of potential mutagenic activity is a critical step in the assessment of the safety of both new and pre-existing chemical types. In Genetic Toxicology: Principles and Methods, expert contributors help to satisfy the demand for education in this tremendously important area of study.  The volume covers three basic areas: the scientific basis of the discipline, the methodologies of the main test assays, and the application of the methods, all aimed primarily at scientists in the safety departments of the industries working with both natural and synthetic chemicals.  Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

 

Intuitive and cutting-edge, Genetic Toxicology: Principles and Methods provides crucial support to both laboratory workers in providing quality information on the appropriate application of techniques and to study directors in their assay selection and protocol design in this vital field.

Editors and Affiliations

  • Lyndhurst, United Kingdom

    James M. Parry, Elizabeth M. Parry

Bibliographic Information

  • Book Title: Genetic Toxicology

  • Book Subtitle: Principles and Methods

  • Editors: James M. Parry, Elizabeth M. Parry

  • Series Title: Methods in Molecular Biology

  • DOI: https://doi.org/10.1007/978-1-61779-421-6

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media, LLC 2012

  • Hardcover ISBN: 978-1-61779-420-9Published: 07 December 2011

  • Softcover ISBN: 978-1-4939-5736-1Published: 23 August 2016

  • eBook ISBN: 978-1-61779-421-6Published: 08 December 2011

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 1

  • Number of Pages: XVI, 433

  • Number of Illustrations: 68 b/w illustrations, 46 illustrations in colour

  • Topics: Pharmacology/Toxicology, Human Genetics

Buy it now

Buying options

eBook USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 159.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access