The Skeleton

1. Front Matter

   Pages i-xviii

   PDF

2. Chondrogenesis, Chondrocytes, and Cartilage

   1. Front Matter

      Pages 1-1

      PDF

   2. Molecular Basis of Cell—Cell Interaction and Signaling in Mesenchymal Chondrogenesis

      • Rocky S. Tuan

      Pages 3-15

   3. Chondrocyte Cell Fate Determination in Response to Bone Morphogenetic Protein Signaling

      • Lillian Shum, Yuji Hatakeyama, Julius Leyton, Kazuaki Nonaka

      Pages 17-42

   4. Regulation of Chondrocyte Differentiation

      • Andreia M. Ionescu, M. Hicham Drissi, Regis J. O’Keefe

      Pages 43-53

   5. Continuous Expression of Cbfa1 in Nonhypertrophic Chondrocytes Uncovers Its Ability to Induce Hypertrophic Chondrocyte Differentiation and Partially Rescues Cbfa1-Deficient Mice

      • Shu Takeda, Jean-Pierre Bonnamy, Michael J. Owen, Patricia Ducy, Gerard Karsenty

      Pages 55-75

   6. Molecular Biology and Biosynthesis of Collagens

      • Johanna Myllyharju

      Pages 77-87

   7. Mechanotransduction Pathways in Cartilage

      • Qian Chen

      Pages 89-98

3. Control of Skeletal Development

   1. Front Matter

      Pages 99-99

      PDF

   2. Molecular Genetic Analysis of the Role of the HoxD Complex in Skeletal Development

      • Marie Kmita, Denis Duboule, József Zákány

      Pages 101-112

   3. Control of Development and Homeostasis Via Regulation of BMP, Wnt, and Hedgehog Signaling

      • Renee Hackenmiller, Catherine Degnin, Jan Christian

      Pages 113-130

   4. FGF4 and Skeletal Morphogenesis

      • Valerie Ngo-Muller, Shaoguang Li, Scott A. Schaller, Manjong Han, Jennifer Farrington, Minoru Omi et al.

      Pages 131-145

   5. Retinoid Signaling and Skeletal Development

      • Andrea D. Weston, T. Michael Underhill

      Pages 147-157

   6. Retinoids and Indian Hedgehog Orchestrate Long Bone Development

      • Maurizio Pacifici, Chiara Gentili, Eleanor Golden, Eiki Koyama

      Pages 159-170

4. Osteoblastic Cell Differentiation

   1. Front Matter

      Pages 171-171

      PDF

   2. Synergy Between Osteogenic Protein-1 and Osteotropic Factors in the Stimulation of Rat Osteoblastic Cell Differentiation

      • John C. Lee, Lee-Chuan C. Yeh

      Pages 173-183

   3. Bone Morphogenic Proteins, Osteoblast Differentiation, and Cell Survival During Osteogenesis

      • Cun-Yu Wang

      Pages 185-193

   4. Osteoclast Differentiation

      • Sakamuri V. Reddy, G. David Roodman

      Pages 195-213

5. Bone Induction, Growth, and Remodeling

   1. Front Matter

      Pages 215-215

      PDF

   2. Soluble Signals and Insoluble Substrata

      • Ugo Ripamonti, Nathaniel L. Ramoshebi, Janet Patton, Thato Matsaba, June Teare, Louise Renton

      Pages 217-227

A cutting-edge review of the biochemical, physiological, pharmacological, genetic, and molecular interactions involved in the development and homeostasis of the skeleton. Topics range from chondrogenesis, chondrocytes, and cartilage to skeletal dysmorphology, and include the control of skeletal development, osteoblastic cell differentiation, and bone induction, growth, remodeling, and mineralization. The authors' understanding of bone physiology-and how it is modified throughout all the stages of life-offers novel approaches for improving the endurance of load-bearing implants, achieving life-long optimal bone strength, overcoming microgravity situations (space flight), and hastening the healing of fractures, osteotomies, and antrodeses.

• biology
• bone
• cartilage
• cell
• fracture
• implant
• morphology
• osteotomy
• physiology
• skeleton
• tissue

"...a valuable book...Every substantial biomedical library should have this book." -Doody's Health Sciences Book Review Journal

"Very detailed, clinical and laden with biological terminology, which makes the preface a must for new readers." -E-STREAMS

"Authoritative and up-to-date... a cutting-edge survey of diverse critical issues in bone biology." - Clinical Laboratory International

• Developmental Biology Branch, Reproductive Toxicology Division, The National Health and Environmental Effects Research Laboratory, Office of Research Development, United States Environmental Protection Agency, Research Triangle Park, USA

  Edward J. Massaro, John M. Rogers

Policies and ethics