Experimental and Applied Immunotherapy

1. Front Matter

   Pages i-xvii

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2. T Cell Therapy: State-of-the-Art

   1. Front Matter

      Pages 1-1

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   2. Extending the Use of Adoptive T Cell Immunotherapy for Infections and Cancer

      • Ulrike Gerdemann, Malcolm K. Brenner

      Pages 3-33

3. Non-T Cell Therapeutic Approaches

   1. Front Matter

      Pages 35-35

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   2. B Lymphocytes in Cancer Immunology

      • David Spaner, Angela Bahlo

      Pages 37-57

   3. Monoclonal Antibody Therapy for Cancer

      • Christoph Rader

      Pages 59-83

   4. Natural Killer Cells for Cancer Immunotherapy

      • Yoko Kosaka, Armand Keating

      Pages 85-105

   5. Dendritic Cell-Based Cancer Vaccines: Practical Considerations

      • Elizabeth Scheid, Michael Ricci, Ronan Foley

      Pages 107-126

   6. Mesenchymal Stromal Cells: An Emerging Cell-Based Pharmaceutical

      • Moïra François, Jacques Galipeau

      Pages 127-148

4. T Cell Therapeutic Approaches

   1. Front Matter

      Pages 149-149

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   2. Tumor-Specific Mutations as Targets for Cancer Immunotherapy

      • Brad H. Nelson, John R. Webb

      Pages 151-172

   3. Counteracting Subversion of MHC Class II Antigen Presentation by Tumors

      • Jacques Thibodeau, Marie-Claude Bourgeois-Daigneault, Réjean Lapointe

      Pages 173-194

   4. Mechanisms and Implications of Immunodominance in CD8+ T-Cell Responses

      • Claude Perreault

      Pages 195-206

   5. T Regulatory Cells and Cancer Immunotherapy

      • Adele Y. Wang, Megan K. Levings

      Pages 207-228

   6. Negative Regulators in Cancer Immunology and Immunotherapy

      • Wolfgang Zimmermann, Robert Kammerer

      Pages 229-249

   7. Genetically Engineered Antigen Specificity in T Cells for Adoptive Immunotherapy

      • Daniel J. Powell Jr, Bruce L. Levine

      Pages 251-278

5. Non-Cellular Aspects of Cancer Immunotherapy

   1. Front Matter

      Pages 279-279

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   2. Cytokine Immunotherapy

      • Megan Nelles, Vincenzo Salerno, Yixin Xu, Christopher J. Paige

      Pages 281-305

   3. Transcriptional Modulation Using Histone Deacetylase Inhibitors for Cancer Immunotherapy

      • Takashi Murakami

      Pages 307-322

   4. Combining Cancer Vaccines with Conventional Therapies

      • Natalie Grinshtein, Jonathan Bramson

      Pages 323-338

Immunotherapy is now recognized as an essential component of treatment for a wide variety of cancers. It is an interdisciplinary field that is critically dependent upon an improved understanding of a vast network of cross-regulatory cellular populations and a diversity of molecular effectors; it is a leading example of translational medicine with a favorable concept-to-clinical-trial timeframe of just a few years. There are many established immunotherapies already in existence, but there are exciting new cancer immunotherapies just on the horizon, which are likely to be more potent, less toxic and more cost effective than many therapies currently in use. Experimental and Applied Immunotherapy is a state-of-the-art text offering a roadmap leading to the creation of these future cancer-fighting immunotherapies. It includes essays by leading researchers that cover a wide variety of topics including T cell and non-T cell therapy, monoclonal antibody therapy, dendritic cell-based cancer vaccines, mesenchymal stromal cells, negative regulators in cancer immunology and immunotherapy, non-cellular aspects of cancer immunotherapy, the combining of cancer vaccines with conventional therapies, the combining of oncolytic viruses with cancer immunotherapy, transplantation, and more. The field of immunotherapy holds great promise that will soon come to fruition if creative investigators can bridge seemingly disparate disciplines, such as T cell therapy, gene therapy, and transplantation therapy. This text is a vital tool in the building of that bridge.

• Cancer
• Immunotherapy
• translational immunotherapy

From the reviews:

“The text is divided into five parts, each comprising of one or more chapters written by word-renowned scientists in the field. … the editors have made an excellent effort to incorporate most relevant topics on immunotherapy in this textbook, and most chapters have been well written with supporting diagrams and tables. The text provides researchers in the field with up-to-date concepts and detailed current and future strategies for cancer immunotherapy.” (Ali Roghanian, Immunology News, May, 2012)

“Cancer immunotherapy is a vast area of research and it is covered in some depth by this very informative book. Each of the 19 chapters consists of a quick introduction to the specific area of interest of one of the contributors followed by in-depth analysis of experimental techniques currently being used successfully, or otherwise, in the field. … Overall, an enlightening book that covers a variety of immunotherapy techniques, but the book is directed specifically at those interested in cancer treatment.” (Donal Wall, Microbiology Today, November, 2011)

“A highly informative compendium of essays with a heavy focus on cancer immunotherapy. … the essays are excellent and present the state of the art of many emerging and established immunotherapies for cancer. … Immunisation approaches are considered by several authors. … I can recommend this excellent collection of succinct essays that span the breath of ongoing research in cancer immunotherapy.” (British Journal of Clinical Pharmacology, May, 2011)

• University Health Network, University of Toronto, Toronto, Canada

  Jeffrey Medin

• National Cancer Institute, Experimental Transplatation &, National Institutes of Health, Bethesda, USA

  Daniel Fowler

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