Systems Biology in Drug Discovery and Development

1. Front Matter

   Pages i-xii

   PDF

2. Methodologies of Systems Biology in Drug Discovery and Development

   1. Front Matter

      Pages 1-1

      PDF

   2. Proteomics and Systems Biology: Application in Drug Discovery and Development

      • Bulbul Chakravarti, Buddhadeb Mallik, Deb N. Chakravarti

      Pages 3-28

   3. Systems Biology Approaches and Tools for Analysis of Interactomes and Multi-target Drugs

      • André Schrattenholz, Karlfried Groebe, Vukic Soskic

      Pages 29-58

   4. Systems Biology “On-the-Fly”: SILAC-Based Quantitative Proteomics and RNAi Approach in Drosophila melanogaster

      • Alessandro Cuomo, Tiziana Bonaldi

      Pages 59-78

   5. Systems Biology of Cell Behavior

      • Najl V. Valeyev, Declan G. Bates, Yoshinori Umezawa, Antonina N. Gizatullina, Nikolay V. Kotov

      Pages 79-95

   6. Computational Modeling in Systems Biology

      • Ravishankar R. Vallabhajosyula, Alpan Raval

      Pages 97-120

   7. An Introduction to Gaussian Bayesian Networks

      • Marco Grzegorczyk

      Pages 121-147

   8. Derivation of Large-Scale Cellular Regulatory Networks from Biological Time Series Data

      • Benjamin L. de Bivort

      Pages 149-165

   9. Translational Bioinformatics and Systems Biology Approaches for Personalized Medicine

      • Qing Yan

      Pages 167-178

3. Systems Biology Methods for Disease Treatment and Translational Medicine

   1. Front Matter

      Pages 179-179

      PDF

   2. Systems Biology and Inflammation

      • Yoram Vodovotz, Gary An

      Pages 181-201

   3. Immunoinformatics and Systems Biology Methods for Personalized Medicine

      • Qing Yan

      Pages 203-220

   4. Systems Biology Approaches to the Study of Cardiovascular Drugs

      • Yuri Nikolsky, Robert Kleemann

      Pages 221-243

   5. Cancer Systems Biology

      • Dana Faratian, James L. Bown, V. Anne Smith, Simon P. Langdon, David J. Harrison

      Pages 245-263

   6. Systemic Lupus Erythematosus: From Genes to Organ Damage

      • Vasileios C. Kyttaris

      Pages 265-283

   7. Systems Biology of Influenza: Understanding Multidimensional Interactions for Personalized Prevention and Treatment

      • Qing Yan

      Pages 285-302

   8. Methods in Systems Biology of Experimental Methamphetamine Drug Abuse

      • Firas H. Kobeissy, Shankar Sadasivan, Melinda Buchanan, Zhiqun Zhang, Mark S. Gold, Kevin K. W. Wang

      Pages 303-316

   9. Systems Biology and Theranostic Approach to Drug Discovery and Development to Treat Traumatic Brain Injury

      • Zhiqun Zhang, Stephen F. Larner, Firas Kobeissy, Ronald L. Hayes, Kevin K. W. Wang

      Pages 317-329

4. Erratum

   1. Erratum to: Cancer Systems Biology

      • Dana Faratian, James L. Bown, V. Anne Smith, Simon P. Langdon, David J. Harrison

      Pages E1-E1

Due to the failing “one-drug-fits-all” model, it has become increasingly necessary to develop personalized medicine that treats whole systems and brings the right drug to the right patient with the right dosages. In Systems Biology in Drug Discovery and Development: Methods and Protocols, leading experts provide a practical, state-of-the-art, and holistic view of the translation of systems biology into better drug discovery and personalized medical practice. While the first part of the book describes cutting-edge technologies and methods in the field, the second part illustrates how the technologies can be applied in science for disease understanding and therapeutic discovery. As a volume in the highly successful Methods in Molecular Biology™ series, this collection provides the kind of detailed description and implementation advice that is crucial for getting optimal results. Authoritative and up-to-date, Systems Biology in Drug Discovery and Development: Methods and Protocols covers topics from fundamental concepts to advanced technologies in order to best serve biomedical students and professionals at all levels who are interested in vital integrative studies in molecular biology, genetics, bioinformatics, bioengineering, biochemistry, physiology, pathology, microbiology, immunology, pharmacology, toxicology, drug discovery, and clinical medicine.

• Disease prevention and health promotion
• Holistic techniques
• Individualized therapeutics
• Personalized medicine
• Pharmaceuticals
• Translation
• Translational medicine
• amphetamine
• bioinformatics
• molecular biology
• physiology
• Systems Biology

From the reviews:

“This book describes state-of-the-art technologies and methods in molecular biology and the necessary integration of data … . The resultant book provides an effective resource for students, biologists, and physicians in multiple disciplines, as well as individuals involved in the drug development process. … This is a very effective and comprehensive guide to the advances in molecular biology methods and computational tools that model complex biological systems as a means to better understand disease mechanisms and identify appropriate drug candidates for individualized therapies.” (Rachel Renee Chennault, Doody’s Review Service, February, 2011)

• PharmTao, Santa Clara, USA

  Qing Yan

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